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This medication comes with important safety information that outlines potential risks and necessary precautions. Please carefully review the warnings below and consult with your healthcare provider if you have any concerns.

• Hormone Issues and Withdrawal: Prolonged use of hydrocortisone (Anusol-HC) rectally can lead to a rare condition called adrenal suppression, where the body reduces its own steroid production. Abruptly stopping the medication may result in withdrawal symptoms such as dizziness, fatigue, and nausea. To avoid this, your healthcare provider may suggest a rectal exam to ensure this treatment is suitable for you. Do not discontinue hydrocortisone (Anusol-HC) without consulting your provider. Risks include long-term use, excessive use, bandaging the treated area, and use in young children.

• Increased Risk of Skin Infections: Long-term use of hydrocortisone (Anusol-HC) can increase the likelihood of fungal or bacterial infections. It should not be used if you have a skin infection, as it may exacerbate the condition. Notify your healthcare provider if you experience redness, swelling, pain, pus, or if symptoms persist beyond seven days, as these could indicate a new infection.

• Skin Reactions: Extended use beyond your provider’s recommendations may lead to skin irritation, thinning, stretch marks, spider veins, burning, itching, dryness, inflamed hair follicles, changes in skin pigmentation, or rash. To minimize severe skin reactions, your provider may recommend a rectal exam to confirm the appropriateness of this medication. Report any new or worsening skin issues to your provider immediately. Risks include excessive and improper use of hydrocortisone (Anusol-HC).

Always follow your healthcare provider's instructions and report any adverse effects or concerns promptly.

When using this medication, you may experience some common side effects, which are generally mild and temporary. These include redness, burning, itching, skin irritation, and dry skin. If these symptoms persist or worsen, it's advisable to consult a healthcare professional for guidance.

There are other side effects that, while not as common, should be monitored. These can include inflamed hair follicles, acne-like bumps, changes in skin color, rash or heat rash, thinning skin, stretch marks, skin pruning or wrinkling, and increased hair growth. Although these are typically manageable, you should contact a healthcare provider if they become bothersome.

Serious side effects are rare but require immediate medical attention. These include rectal bleeding, significant changes in skin appearance such as increased redness, tenderness, or pus indicating infection, and signs of systemic infection like a persistent sore throat or fever. Additionally, the medication can rarely be absorbed into the bloodstream, leading to symptoms like unusual tiredness, weight loss, headache, swelling of the ankles or feet, increased thirst or urination, and vision problems. If you encounter any of these, seek urgent medical care.

In extremely rare cases, a severe allergic reaction may occur. Symptoms might include a rash, severe itching or swelling, especially on the face, tongue, or throat, severe dizziness, and difficulty breathing. If you notice these, seek emergency medical help immediately. Always be vigilant and report any unexpected reactions to your healthcare provider.