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When using Tagrisso (osimertinib), it is crucial to be aware of certain safety considerations due to potential risks. Below is a summary of important warnings and guidance for patients and healthcare providers:

• Lung Complications: Although uncommon, Tagrisso may cause a serious lung condition known as interstitial lung disease (ILD). If you experience new or worsening symptoms such as a cough, difficulty breathing, or fever, promptly contact your healthcare provider. Temporary discontinuation or cessation of the medication may be necessary for evaluation.

• Cardiac Concerns: Some patients might experience changes in heart rhythm, known as QTc prolongation. If you have a congenital long QT syndrome or are at risk due to other medications, closer monitoring through an electrocardiogram (EKG) may be required. Should symptoms like dizziness, chest pain, or weakness occur, a medication change might be considered.

• Eye Issues: Tagrisso can occasionally lead to eye problems, including swelling. If you notice eye pain, blurred vision, redness, or increased light sensitivity, seek medical attention. An ophthalmologist consultation might be recommended.

• Skin Reactions: While mild rashes can occur, Tagrisso has the potential to cause severe skin issues, such as Stevens-Johnson syndrome, which could be life-threatening. Immediate medical attention is required if you develop painful blisters, skin wounds, or peeling.

• Blood Disorders: There is a rare risk of developing aplastic anemia, a serious condition affecting blood cell production. Report any new bruising, bleeding, fever, or pale skin to your provider immediately. Temporary discontinuation of Tagrisso may be necessary to assess the cause.

• Pregnancy Risks: Animal studies suggest that Tagrisso could harm an unborn child or increase miscarriage risk. Females capable of pregnancy should use contraception during treatment and for 6 weeks after the final dose. Males should use condoms during treatment and for 4 months post-treatment. A negative pregnancy test may be required before starting Tagrisso, and any pregnancy should be reported to a healthcare provider immediately.

Please consult your healthcare provider for further clarification or if you have any concerns regarding the use of Tagrisso.

When taking this medication, some common side effects may occur, but they are usually mild and manageable. These include diarrhea, dry or itchy skin, fatigue, back pain, headache, loss of appetite, and cough. Some people may experience changes in their nails, such as tenderness or color changes, as well as acne-like rashes, muscle aches, and mouth sores. If any of these symptoms persist or become bothersome, consulting a healthcare professional is advisable.

Certain side effects, though less common, still require attention. These include nausea, vomiting, constipation, and itchy skin. While these may cause discomfort, they typically do not pose serious health risks. However, if they persist, it's wise to seek medical advice.

There are also severe side effects that, although rare, necessitate immediate medical care. These include signs of serious lung issues like sudden coughing, fever, difficulty breathing, and chest tightness. Serious heart problems such as heart failure or fluid in the lungs may be indicated by trouble breathing, leg swelling, and severe fatigue. Blood problems might manifest as sudden fatigue, easy bruising, or bleeding, and fever. Additionally, serious skin reactions, including painful blisters or peeling skin, require urgent attention.

It is also important to be aware that this medication can lower your body's ability to fight infections, making you more susceptible to them. If you experience symptoms of an infection such as a persistent sore throat, fever, or chills, contact your healthcare provider promptly. In rare instances, a severe allergic reaction may occur, with symptoms like rash, swelling, severe dizziness, or breathing difficulties, which require immediate medical intervention. If you notice any side effects not listed here, discussing them with your healthcare provider is recommended.