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When using Tagrisso (osimertinib), it is crucial to be aware of certain safety considerations due to potential risks. Below is a summary of important warnings and guidance for patients and healthcare providers:

• Lung Complications: Although uncommon, Tagrisso may cause a serious lung condition known as interstitial lung disease (ILD). If you experience new or worsening symptoms such as a cough, difficulty breathing, or fever, promptly contact your healthcare provider. Temporary discontinuation or cessation of the medication may be necessary for evaluation.

• Cardiac Concerns: Some patients might experience changes in heart rhythm, known as QTc prolongation. If you have a congenital long QT syndrome or are at risk due to other medications, closer monitoring through an electrocardiogram (EKG) may be required. Should symptoms like dizziness, chest pain, or weakness occur, a medication change might be considered.

• Eye Issues: Tagrisso can occasionally lead to eye problems, including swelling. If you notice eye pain, blurred vision, redness, or increased light sensitivity, seek medical attention. An ophthalmologist consultation might be recommended.

• Skin Reactions: While mild rashes can occur, Tagrisso has the potential to cause severe skin issues, such as Stevens-Johnson syndrome, which could be life-threatening. Immediate medical attention is required if you develop painful blisters, skin wounds, or peeling.

• Blood Disorders: There is a rare risk of developing aplastic anemia, a serious condition affecting blood cell production. Report any new bruising, bleeding, fever, or pale skin to your provider immediately. Temporary discontinuation of Tagrisso may be necessary to assess the cause.

• Pregnancy Risks: Animal studies suggest that Tagrisso could harm an unborn child or increase miscarriage risk. Females capable of pregnancy should use contraception during treatment and for 6 weeks after the final dose. Males should use condoms during treatment and for 4 months post-treatment. A negative pregnancy test may be required before starting Tagrisso, and any pregnancy should be reported to a healthcare provider immediately.

Please consult your healthcare provider for further clarification or if you have any concerns regarding the use of Tagrisso.

Tagrisso (osimertinib) is a medication prescribed for certain types of non-small cell lung cancer. It's important to be aware of potential interactions between Tagrisso and other substances, as these can affect the drug's effectiveness or increase the risk of side effects.

Interactions with Other Medications

Tagrisso can interact with various medications, leading to serious health risks. Notable interactions include:

• Antibiotics: Certain antibiotics, such as Azithromycin, Clarithromycin, and Moxifloxacin, can increase the risk of a heart condition known as long QT syndrome when taken with Tagrisso. This condition can lead to irregular heartbeats, which may be life-threatening.

• Seizure Medications: Drugs like Carbamazepine, Phenobarbital, and Phenytoin may reduce the effectiveness of Tagrisso by speeding up its breakdown in the body.

• Heart Rhythm Medications: Medications such as Amiodarone and Sotalol, used to manage heart rhythm disorders, can also raise the risk of long QT syndrome when combined with Tagrisso.

• Antidepressants and Antipsychotics: Some antidepressants (e.g., Citalopram, Escitalopram) and antipsychotics (e.g., Aripiprazole, Quetiapine) may increase the likelihood of developing long QT syndrome when taken with Tagrisso.

• Loperamide: Commonly used to treat diarrhea, loperamide can heighten the risk of long QT syndrome when used alongside Tagrisso.

Interactions with Supplements and Herbal Products

Certain supplements and herbal products can also interact with Tagrisso:

• St. John's Wort: This herbal supplement can decrease the effectiveness of Tagrisso by accelerating its breakdown in the body. It's advisable to avoid St. John's Wort during Tagrisso treatment.

Alcohol and Food Interactions

There are no known direct interactions between Tagrisso and specific foods or alcohol. However, both Tagrisso and alcohol can cause similar side effects, such as nausea and diarrhea. Consuming alcohol while on Tagrisso may intensify these side effects. It's recommended to discuss alcohol consumption with your healthcare provider during treatment.

Health Conditions and Tagrisso

Certain health conditions can influence how Tagrisso affects your body:

• Heart Problems: If you have existing heart conditions, especially those affecting heart rhythm, Tagrisso may increase the risk of complications.

• Electrolyte Imbalances: Low levels of potassium or magnesium can raise the risk of long QT syndrome when taking Tagrisso.

• Lung or Breathing Issues: Tagrisso may cause lung inflammation or scarring, which could worsen existing lung conditions.

• Blood Cell Counts: Tagrisso can lower red and white blood cell counts, as well as platelets. If you already have low blood cell counts, this effect may be more pronounced.

Preventing Interactions

To minimize the risk of interactions:

• Inform Your Healthcare Provider: Before starting Tagrisso, provide a complete list of all medications, supplements, and herbal products you are taking.

• Monitor for Side Effects: Be vigilant for symptoms like irregular heartbeats, dizziness, or fainting, and report them to your doctor immediately.

• Regular Check-ups: Your doctor may conduct periodic tests to monitor your heart function and electrolyte levels during treatment.

Always consult your healthcare provider before making any changes to your medication regimen to ensure safe and effective use of Tagrisso.