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This medication comes with critical safety information that you should review carefully. If you have any questions or concerns, please consult your healthcare provider. Below are the potential risks, precautions, and special instructions associated with this drug:

• Facial Swelling and Breathing Issues: Some individuals taking trospium have experienced angioedema, a rare but serious condition characterized by swelling in areas such as the face, throat, and tongue. This can be life-threatening if it obstructs breathing. Seek immediate emergency medical help if you encounter sudden breathing difficulties or facial swelling.

• Nervous System Effects: Trospium may cause drowsiness, dizziness, and hallucinations. Avoid driving or engaging in tasks that require intense focus until you understand how the medication affects you. Inform your healthcare provider if these side effects occur and interfere with your daily activities, as a dosage adjustment may be necessary.

• Urination Difficulties: Exercise caution when using trospium if you have conditions like prostate issues or urinary tract blockages, as it may exacerbate urination problems.

• Stomach Concerns: Trospium can significantly slow down gastrointestinal movement, potentially leading to severe conditions such as inflammation or swelling of the colon. If you have a history of gastrointestinal disorders, such as ulcerative colitis, or nerve-related issues like myasthenia gravis, discuss these with your healthcare provider to determine if trospium is appropriate for you.

• Glaucoma Warning: Trospium may cause blurred vision or worsen glaucoma symptoms. If you have glaucoma, inform both your primary care provider and ophthalmologist before starting trospium. Regular eye examinations are advised for those with glaucoma taking this medication.

Contraindications: This medication should not be used in the following conditions due to potential serious health risks. Consult your healthcare provider if any apply to you:

• Uncontrolled narrow-angle glaucoma
• Inability to urinate or fully empty the bladder (urinary retention), such as due to prostate issues
• Blockage in the stomach or intestines

For any overdose, seek immediate medical attention.

Common side effects:

• Dry mouth
• Constipation
• Headache
• Stomach upset
• Dizziness
• Blurred vision
• Drowsiness
• Dry eyes

Less common but important to monitor:

• Trouble emptying your bladder
• Fatigue
• Sleepiness

Serious side effects:

• Eye pain
• Difficulty urinating
• Fast heartbeat
• Mental or mood changes
• Hallucinations
• Confusion
• Allergic reaction (rash, itching or swelling, severe dizziness, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Potassium tablets/capsules

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Pramlintide
• Amifampridine
• Bupropion
• Clozapine
• Donepezil
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Methacholine
• Quetiapine
• Revefenacin
• Scopolamine
• Secretin Human
• Tiotropium

Interactions with low risk that usually do not require a change in therapy:

• Alcohol
• Marijuana (cannabis)
• Cetirizine
• Diphenhydramine
• Alprazolam
• Diazepam
• Zolpidem
• Muscle relaxants
• Opioid pain relievers (such as codeine)