5-fluorouracil

Drug Details

Fluorouracil (Efudex) topical is a medication used to manage skin conditions such as actinic keratosis and basal cell carcinoma. Available as a 5% cream and solution or a 2% solution, this antimetabolite works by interfering with the ability of abnormal skin cells to reproduce their genetic material, effectively hindering their growth. The 5% formulation is specifically approved for the treatment of basal cell carcinoma, a common form of skin cancer, while both strengths can address actinic keratosis, a precancerous skin condition caused by prolonged UV exposure. Treatment involves applying the medication directly to the affected area twice daily for a period ranging from 2 to 6 weeks, depending on the condition being treated. Common side effects may include burning, crusting, and irritation of the skin. As with any medication, it is important to consult with a healthcare professional prior to use.