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This safety information outlines important risks and precautions related to the use of Daytrana (methylphenidate). Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

• Risk of Misuse and Addiction: Daytrana (methylphenidate) carries a risk of misuse and addiction. Using the medication in a way other than prescribed can lead to severe side effects such as rapid heart rate, increased blood pressure, aggressive behavior, or thoughts of self-harm. It may also result in addiction. It is crucial to take Daytrana as directed by your healthcare provider. If you have a history of substance or alcohol use disorder, discuss this with your doctor before starting the medication.

• Risk of Dependence and Withdrawal: Long-term use of Daytrana (methylphenidate) may lead to physical dependence. Suddenly stopping or reducing the dose can result in withdrawal symptoms like irritability, nightmares, and sleep issues. Always follow your prescriber’s instructions regarding dosage changes.

• Heart-related Risks: Individuals with pre-existing heart conditions may experience serious cardiac events, such as sudden death or heart attack, when taking Daytrana (methylphenidate). This medication can increase blood pressure and heart rate. If you have a history of heart problems, inform your healthcare provider before using this medication.

• Behavioral and Mental Health Risks: Daytrana (methylphenidate) can cause or exacerbate mental health issues, including hallucinations, aggressive behavior, unclear thinking, and mania. These effects can occur in individuals with no prior history of such conditions. If any mood or behavior changes occur, contact your healthcare provider immediately.

• Growth Concerns in Children: Use of stimulants like Daytrana (methylphenidate) has been associated with slowed growth in children. Regular monitoring of growth by a pediatrician is recommended. If growth concerns arise, the medication may need to be adjusted or discontinued.

• Seizure Risk: Although rare, Daytrana (methylphenidate) may increase the likelihood of seizures, especially in those with a history of seizures. Seek medical attention immediately if a seizure occurs.

• Blood Circulation Issues: Daytrana (methylphenidate) may cause poor blood circulation, such as Raynaud's phenomenon, resulting in cold, numb, or painful fingers and toes. Report any such symptoms to your healthcare provider.

• Eye Pressure and Glaucoma: Rarely, Daytrana (methylphenidate) can lead to increased eye pressure or glaucoma. Regular eye exams are advisable, and any vision changes should be reported to an eye care professional.

• Drug Interactions: Daytrana (methylphenidate) can interact with various medications, potentially reducing the effectiveness of blood pressure medications and increasing the risk of high blood pressure with monoamine oxidase inhibitors (MAOIs). Inform your healthcare team about all medications and supplements your child is taking.

• Contraindications: Do not use Daytrana (methylphenidate) if you are allergic to methylphenidate or have taken an MAOI in the past 14 days.

In case of an overdose, seek emergency medical assistance immediately. Always adhere to the prescribed dosage and consult your healthcare provider for any concerns regarding the use of Daytrana (methylphenidate).

When using this medication, some common side effects may occur. These include nervousness, trouble sleeping, and a decrease in appetite, which can sometimes lead to weight loss. Dizziness, nausea, vomiting, headache, and stomach pain are also possible. Mild irritation or redness may appear at the application site. These effects are usually mild and may resolve on their own, but if they persist or worsen, it is advisable to contact a healthcare professional.

While serious side effects are rare, they do require prompt medical attention. These include signs of blood flow issues in the extremities, such as coldness, numbness, or unusual wounds on fingers and toes. Other serious concerns include a fast or irregular heartbeat, significant mood changes, or uncontrollable muscle movements. Vision changes, prolonged sores, and severe allergic reactions, including rash, swelling, or trouble breathing, also necessitate immediate medical care.

In rare cases, males, including young boys, may experience a painful or prolonged erection lasting more than four hours, which requires urgent medical intervention to prevent lasting damage. Additionally, skin color changes under the patch, which may be permanent, should be reported to a doctor.

Moreover, this medication may raise blood pressure, so regular monitoring is recommended. If you experience any symptoms of a heart attack or stroke, such as chest pain, shortness of breath, or sudden confusion, seek emergency assistance immediately. As with any medication, if you notice side effects not listed here, consult your healthcare provider for advice.

When using Daytrana (Methylphenidate), it's crucial to be aware of potential drug interactions. Combining this medication with MAO inhibitors, such as isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine, can lead to a severe and potentially life-threatening reaction. Therefore, avoid taking these inhibitors while on Daytrana, and wait at least two weeks after stopping an MAO inhibitor before beginning treatment with this medication. Consult your doctor for specific guidance on when to start or stop these medications.

Additionally, avoid using medications containing Dexmethylphenidate alongside Daytrana, as they are very similar. Daytrana may also interfere with certain medical or laboratory tests, such as brain scans for Parkinson's disease, potentially causing inaccurate results. It's important to inform all healthcare professionals involved in your care, including lab personnel, if you are using this medication.

Daytrana may also interact with other medications like furazolidone, iproniazid, and several others, which may require adjustments by your doctor. In some cases, using Daytrana with certain medications such as bupropion or Carbamazepine may increase the risk of side effects, but it might be necessary based on your treatment plan. Always disclose all medications, supplements, and over-the-counter products you are taking to your healthcare provider to ensure safe and effective use of Daytrana.