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When using Xulane (norelgestromin / ethinyl estradiol), it is crucial to be aware of potential risks and take necessary precautions. Below are key safety considerations and warnings that should be reviewed. Consult your healthcare provider for personalized advice.

• Smoking and Blood Clots: Smoking while using this medication significantly increases the risk of blood clots, heart attack, and stroke. This risk is especially high for individuals over the age of 35 with a history of smoking. If you smoke, discuss safer birth control options with your healthcare provider.

• Estrogen Absorption: Xulane results in higher estrogen levels compared to other hormonal contraceptives, which may elevate the risk of blood clots. These can occur in various parts of the body, such as the lungs (pulmonary embolism), legs (deep vein thrombosis), brain (stroke), and heart (heart attack). Seek immediate medical attention if you exhibit symptoms of a blood clot.

• Liver Health: Avoid using Xulane if you have liver issues, including hepatitis, severe cirrhosis, or liver tumors. The medication may increase the risk of benign liver tumors. Monitor for symptoms like jaundice, fever, tiredness, appetite loss, or dark urine, and contact your healthcare provider if they occur.

• Blood Pressure: Xulane can raise blood pressure, particularly if you are older or have used hormonal contraceptives for an extended period. If you have controlled high blood pressure, your healthcare provider may closely monitor your condition while on Xulane.

• Gallbladder Issues: This medication may slightly increase the risk of gallbladder problems. If you have a history of gallbladder or liver conditions, consult your healthcare provider before using Xulane.

• Blood Sugar and Triglycerides: Xulane may elevate blood sugar and triglyceride levels, potentially leading to pancreatitis. If you have prediabetes, diabetes, or high triglycerides, your healthcare provider might suggest monitoring your blood work or considering alternative birth control methods.

• Headaches: Report any new or worsening migraines or headaches to your healthcare provider. Severe or frequent headaches may necessitate discontinuation of the medication.

• Irregular Bleeding: Users may experience breakthrough bleeding or spotting. Consult your healthcare provider to rule out pregnancy or other conditions.

• Depression: If you have a history of depression, your prescriber will monitor your condition. Report any mood changes or worsening depression to your healthcare provider.

• Cancer Risks: There may be an increased risk for breast and cervical cancer with long-term use of combined hormonal contraceptives like Xulane. Discuss your risk factors with your healthcare provider.

• Exacerbation of Other Conditions: Xulane might worsen conditions such as hereditary angioedema or chloasma. Limit sun exposure if you have a history of chloasma.

Contraindications

Do not use Xulane if you meet any of the following criteria, as it may pose serious health risks:

• Over 35 years old and smoke
• History of blood clots or clotting conditions
• Stroke or coronary artery disease
• Uncontrolled high blood pressure
• Diabetes with high blood pressure or organ damage
• Migraine headaches with aura or any migraines if over 35
• Body mass index (BMI) of 30 kg/m² or higher
• Liver disease or unexplained vaginal bleeding
• History of breast cancer
• Taking hepatitis C medications containing ombitasvir/paritaprevir/ritonavir

For any concerns or if you experience symptoms of an overdose, seek medical attention immediately. Always consult your healthcare provider for advice tailored to your health condition.

When using this medication, some common side effects may occur, but they are often mild. These include skin irritation at the application site, nausea, vomiting, headache, bloating, breast tenderness or discomfort, swelling of the ankles or feet due to fluid retention, weight changes, menstrual cramps, stomach pain, and changes in mood. Some may also experience vaginal bleeding between periods, especially in the initial months of use. If these effects persist or worsen, it is advisable to consult your healthcare provider for further guidance.

In some cases, other side effects such as diarrhea, dizziness, migraines, fatigue, acne, itching, vaginal yeast infections, and weight gain might be experienced. Although these are less common, it is important to monitor them and seek medical advice if necessary.

There are rare but serious side effects that require immediate medical attention. These include symptoms of heart attack (such as chest pain and dizziness), stroke (such as sudden numbness or confusion), deep vein thrombosis (such as leg swelling and pain), and pulmonary embolism (such as chest pain and trouble breathing). Additionally, liver problems may manifest as yellowing of the skin or eyes, and significant fatigue. A very serious allergic reaction is also rare but warrants urgent medical care if symptoms like rash, severe dizziness, or trouble breathing occur.

While this medication may raise blood pressure, regular monitoring is recommended. If you experience any unusual or severe symptoms, it is crucial to seek prompt medical attention. This summary is not exhaustive, so if you notice any other side effects, contact your healthcare provider for advice.

When using Xulane (norelgestromin/ethinyl estradiol), it's important to be aware of potential interactions with other medications. Some drugs that should not be taken with Xulane include Dasabuvir, Ombitasvir, Paritaprevir, Ritonavir, and Tranexamic Acid. These interactions could require your doctor to either avoid prescribing Xulane or adjust your other medications.

Furthermore, certain medications might not be recommended to use with Xulane but may be necessary in some situations. If prescribed together, your healthcare provider may adjust the dosage or frequency of either or both medications. Such drugs include Amifampridine, Amoxicillin, Ampicillin, Amprenavir, Anagrelide, Apalutamide, and many others. These can potentially decrease the effectiveness of hormonal birth control, increasing the risk of pregnancy.

Additionally, using Xulane alongside certain medications can elevate the chance of specific side effects, though it might be deemed the best treatment option for you. Your doctor may need to modify the dosage of one or both drugs if prescribed together. Examples include Amitriptyline, Atazanavir, Clomipramine, Diazepam, and others.

Finally, this medication may interfere with certain laboratory tests, such as those assessing blood clotting factors or thyroid function, potentially leading to inaccurate results. Ensure that all healthcare professionals involved in your care are aware that you are using this medication. Always inform your doctor of any new drugs you start and discuss if additional birth control measures are necessary, especially if you experience unusual spotting or breakthrough bleeding.