Zafemy is a limited distribution medication.

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Norelgestromin-eth Estradiol

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norelgestromin-eth estradiol

The Zafemy patch is a hormonal contraceptive designed to prevent pregnancy. It combines two hormones: norelgestromin (a progestin) and ethinyl estradiol (an estrogen). These hormones work together to effectively stop pregnancy by regulating hormones in the body. When used correctly, the patch is 99% effective. It is applied to the skin once a week and can be placed on the upper arm, stomach, buttock, or back. However, it may be less effective for individuals weighing over 198 pounds or with a BMI of 30 kg/m² or higher. While the patch does not protect against sexually transmitted infections, using a condom can help reduce the risk of STIs. Possible side effects include breast tenderness, headaches, or skin irritation at the application site. For personalized medical advice, it is important to consult a healthcare professional.
Our Zafemy coupons are free to use. You can print the coupon, email it to yourself, or receive the Zafemy coupon via text message. To get your free discount, show the pharmacist your Zafemy savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Zafemy prices will update based on your prescription needs. Above our Zafemy coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Zafemy savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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150-35MCG/24HR, Norelgestromin-eth Estradiol (30 Patch Weeklies)

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CVS

$582.93

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Walgreens

$387.35

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Rite Aid

$1084.83

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Walmart

$1106.62

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Albertsons

$1160.99

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Zafemy savings card

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CVS

$582.93

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Zafemy dosage forms

The average cost for 30 Patch Weeklies of Zafemy (norelgestromin-eth estradiol) at 150-35MCG/24HR is $394.99 with a free coupon. This is 24.64% off the average retail price of $1603.35
DosageQuantityPrice fromPer unit
150-35MCG/24HR30 Patch Weeklies$394.99$13.17

Zafemy Warnings

The use of hormonal birth control, such as Zafemy (norelgestromin / ethinyl estradiol), comes with important safety considerations. It is crucial to understand the risks and warnings associated with this medication to ensure its safe use. Below is a summary of the key safety information:

  • Smoking and Risk of Blood Clots: Smoking while using Zafemy significantly elevates the risk of developing blood clots, which can lead to severe health issues such as heart attacks and strokes. This risk increases for individuals over the age of 35 who smoke. It is advised that smokers consult their healthcare provider about safer contraceptive options.

  • Increased Estrogen Absorption: Zafemy delivers a higher dose of estrogen compared to many other hormonal contraceptives, which may elevate the risk of blood clots and other side effects. Be vigilant for symptoms of blood clots, such as sudden chest pain, shortness of breath, or severe headaches, and seek immediate medical attention if they occur.

  • Liver Health: Avoid using Zafemy if you have liver issues such as hepatitis, severe cirrhosis, or liver tumors, as it can exacerbate these conditions. Signs of liver problems include jaundice, fatigue, and dark urine. Discuss alternative birth control methods with your healthcare provider if you have a history of liver problems.

  • Blood Pressure Concerns: This medication can increase blood pressure, especially in older individuals or those with a history of hypertension. Regular monitoring may be necessary, and discussing potential risks with your healthcare provider is recommended.

  • Gallbladder and Blood Sugar: Zafemy may increase the risk of gallbladder issues and elevate blood sugar and triglyceride levels. Individuals with pre-existing gallbladder problems, diabetes, or high triglycerides should discuss these risks with their prescriber.

  • Headaches and Depression: Report any new or worsening headaches to your healthcare provider, as well as any symptoms of depression, such as mood changes or loss of interest in activities. Monitoring is important for those with a history of depression.

  • Cancer Risks: There is inconclusive evidence regarding the increased risk of breast and cervical cancer with the use of hormonal contraceptives like Zafemy. Discuss your personal risk factors with your healthcare provider.

  • Other Health Conditions: Zafemy may worsen certain conditions, such as hereditary angioedema or chloasma. Limit sun exposure if you have a history of chloasma. Discuss these risks with your healthcare provider before starting the medication.

Contraindications:

  • Do not use Zafemy if you are over 35 and smoke, have a history of blood clots, stroke, coronary artery disease, uncontrolled high blood pressure, or certain types of migraines.
  • Individuals with a BMI of 30 kg/m² or higher, those with liver disease, unexplained vaginal bleeding, or a history of breast cancer should avoid this medication.
  • Avoid using Zafemy if you are taking certain hepatitis C treatments.

In case of an overdose or adverse reactions, seek emergency medical assistance immediately. Always consult your healthcare provider to ensure that Zafemy is a safe option for you, considering your health history and current medical conditions.

Zafemy Side Effects

When using this medication, some common side effects may occur, but they are usually mild and temporary. These include skin irritation at the application site, nausea, vomiting, headaches, bloating, breast tenderness, menstrual cramps, and swelling of the ankles or feet due to fluid retention. You might also experience changes in weight, vaginal bleeding between periods, mood changes, or stomach pain. If these persist or worsen, consult your healthcare provider.

In less common instances, users have reported side effects such as diarrhea, dizziness, migraines, tiredness, acne, itching, vaginal yeast infections, and weight gain. While these are generally manageable, seeking advice from a healthcare provider can be beneficial if they cause concern.

There are rare but serious side effects associated with this medication that require immediate medical attention. These include potential blood clots leading to heart attack or stroke, characterized by symptoms such as chest pain, severe headaches, sudden dizziness, trouble speaking, or numbness on one side of the body. Deep vein thrombosis and pulmonary embolism may also occur, presenting as leg pain or swelling, trouble breathing, or a rapid heartbeat. Additionally, liver problems may manifest as yellowing of the skin or eyes and severe abdominal pain.

Although a very serious allergic reaction is rare, seek urgent medical help if you experience symptoms like rash, severe dizziness, or difficulty breathing. Always monitor your blood pressure, as this medication can cause elevations, and inform your healthcare provider if you notice high readings. Remember, while many people use this medication without significant issues, staying informed about potential side effects ensures better health management.

Zafemy Interactions

Certain medications can interact with this drug, potentially affecting its efficacy. These include aromatase inhibitors like anastrozole and exemestane, fezolinetant, ospemifene, tamoxifen, tizanidine, and tranexamic acid. Additionally, some medications might reduce the effectiveness of hormonal birth control by lowering the hormone levels in your body, which could lead to unintended pregnancy. Examples include griseofulvin, modafinil, rifamycins such as rifampin and rifabutin, ritonavir, St. John's wort, and certain seizure medications like barbiturates, carbamazepine, felbamate, phenytoin, primidone, and topiramate. HIV medications, including nelfinavir and nevirapine, may also have this effect. It’s important to inform your doctor when starting any new medication and discuss whether you need additional birth control methods. If you experience any unusual spotting or bleeding, notify your doctor, as these could indicate that your birth control is not functioning properly. Additionally, this drug may affect the results of some lab tests, such as those for blood clotting and thyroid function, so ensure that all healthcare providers and laboratory staff are aware that you are taking this medication.
Zafemy FAQs
What is the drug Zafemy used for?

Zafemy is a transdermal patch used as a form of hormonal contraception to prevent pregnancy. It contains a combination of estrogen and progestin hormones, which work by preventing ovulation, thickening cervical mucus, and altering the uterine lining to prevent fertilization and implantation.

Zafemy and Twirla are both transdermal contraceptive patches, but they differ in their formulation and application. Zafemy, previously known as Xulane, contains ethinyl estradiol and norelgestromin, while Twirla contains ethinyl estradiol and levonorgestrel. Additionally, the adhesive and patch size may vary between the two, which can affect user preference and skin sensitivity. Both are used to prevent pregnancy by releasing hormones through the skin, but the choice between them may depend on individual health considerations and preferences. It is important to consult with a healthcare provider to determine which option is more suitable.

The generic name for the Zafemy patch is norelgestromin and ethinyl estradiol.

Zafemy, a transdermal contraceptive patch, may cause mood swings as a side effect in some individuals. Hormonal contraceptives can affect mood due to changes in hormone levels. If mood swings are severe or persistent, it is advisable to consult a healthcare provider for further evaluation and management.

The choice between Zafemy and Xulane, both of which are transdermal contraceptive patches, depends on individual factors such as personal health, side effects, and cost. Both patches contain similar active ingredients and work in the same way to prevent pregnancy. It is important for the individual to consult with a healthcare provider to determine which option is more suitable for their specific needs and circumstances.