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While using this medication, you might experience mild side effects such as nausea, vomiting, headaches, bloating, breast tenderness, or swelling in the ankles and feet due to fluid retention. Some individuals also notice changes in weight. Vaginal spotting or irregular periods can occur, particularly in the initial months. These effects are generally manageable, but if they persist or worsen, it is important to seek medical advice.

Be aware that this medication can increase blood pressure, so regular monitoring is advised. If you experience significant changes in vaginal bleeding, such as continuous spotting, sudden heavy bleeding, or missed periods, consult your healthcare provider. High potassium levels, indicated by muscle weakness or irregular heartbeat, should also be reported immediately.

There are rare but serious risks associated with blood clots, which can lead to heart attacks, strokes, or clots in the lungs or legs. If you experience symptoms like shortness of breath, chest pain, sudden dizziness, severe headaches, or vision changes, seek immediate medical attention. Additionally, report any severe abdominal pain, unusual mood changes, or signs of liver issues like dark urine or yellowing skin.

Though a serious allergic reaction is uncommon, it requires urgent care if symptoms such as rash, swelling, severe dizziness, or difficulty breathing occur. This overview does not include all possible side effects. If you experience any new or concerning symptoms, contact your healthcare provider for further guidance.

Certain medications may interact with this drug. These include aromatase inhibitors like Anastrozole and Exemestane, Atazanavir combined with cobicistat, fezolinetant, ospemifene, Tamoxifen, Tizanidine, Tranexamic Acid, and specific combination treatments for chronic hepatitis C such as ombitasvir/paritaprevir/[Ritonavir](https://savehealth.com/ritonavir), with or without dasabuvir.

Drospirenone can increase potassium levels in your blood. Inform your doctor if you regularly take other medications that also elevate potassium, such as Aliskiren, ACE inhibitors (e.g., Enalapril, Lisinopril), angiotensin receptor blockers (e.g., Losartan, Valsartan), heparin, NSAIDs (e.g., Ibuprofen, Naproxen), or potassium-sparing diuretics like Eplerenone, Spironolactone, and Triamterene.

Some drugs can reduce the effectiveness of hormonal birth control by lowering hormone levels in your body, which may lead to pregnancy. These include griseofulvin, Modafinil, rifamycins like Rifampin, ritonavir, St. John's wort, certain seizure medications (e.g., barbiturates, Carbamazepine, Felbamate, Phenytoin, Primidone, Topiramate), and some HIV medications such as nelfinavir and Nevirapine. Consult your doctor or pharmacist for more details.

Always inform your doctor when starting a new medication and consider using reliable backup birth control if necessary. Also, report any new spotting or breakthrough bleeding, as these could indicate that your birth control is less effective.

This medication might affect certain lab tests, potentially leading to inaccurate results. Ensure all lab personnel and your doctors are aware that you are taking this medication.