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This medication requires careful consideration and awareness of potential risks and side effects. If you experience any concerns or unusual symptoms, consult your healthcare provider promptly. Below are important safety and warning details:

• Abnormal Sleep Behaviors: Use of this drug may lead to unusual sleep-related actions, including sleepwalking, sleep driving, eating, making phone calls, or engaging in other activities while not fully awake. These activities can occur without memory of the events and pose significant danger. Alcohol or other sedatives can increase these risks, but they can occur even when the medication is taken alone. If you or someone else notices these behaviors, discontinue use immediately and contact your doctor, as a medication change might be necessary.

• Daytime Sleepiness and Cognitive Impairment: This medication can cause drowsiness, dizziness, confusion, and slowed mental function, especially when combined with alcohol or other sedative drugs like benzodiazepines, opioids, or certain antidepressants. Inform your healthcare provider if you take any of these, as a dosage adjustment may be needed. Ensure you have 7 to 8 hours for a full night’s sleep to minimize these effects.

• Severe Allergic Reactions: Some individuals may experience a life-threatening allergic reaction, such as angioedema, characterized by swelling of the tongue, lips, throat, or mouth, along with difficulty breathing, nausea, or vomiting. Seek emergency medical attention if these symptoms occur.

• Behavioral and Mood Changes: The medication may cause abnormal thoughts or changes in behavior, such as aggression, agitation, or hallucinations. Notify your healthcare provider if you experience these symptoms for a thorough evaluation. There is a heightened risk for those with a history of depression or suicidal thoughts.

• Respiratory Depression: Slowed breathing can occur, particularly in individuals with sleep apnea or those using opioids or other respiratory depressants. If you notice breathing changes, inform your healthcare provider as an alternative medication may be necessary.

• Liver Impairment: Individuals with liver issues may process this drug more slowly, increasing the risk of side effects. Those with severe liver problems should avoid this medication due to the risk of brain damage (encephalopathy). Disclose any liver conditions to your healthcare provider before starting treatment.

• Withdrawal Symptoms: Long-term use may lead to tolerance and dependence. Abrupt cessation or dose reduction can cause withdrawal symptoms, including nausea, vomiting, sweating, tremors, panic attacks, and muscle cramps. Consult your healthcare provider if you experience withdrawal symptoms to manage them effectively.

• Contraindications: Do not use this medication if you have experienced abnormal sleep behaviors such as sleepwalking or sleep driving after taking it.

Always communicate with your healthcare provider about any existing health conditions or medications you are taking to ensure your safety while using this medication.

When using this medication, some individuals may experience common side effects such as headaches, sleepiness, dizziness, and diarrhea. These effects are generally mild, but if they persist or worsen, consulting a healthcare provider is advisable for reassurance and guidance.

There are other possible side effects that users have reported, including nausea, dry mouth, back pain, flu-like symptoms, chest pain, fatigue, lightheadedness, depression, abnormal dreams, memory loss, stomach pain, constipation, sinus infections, sore throat, and rash. While these effects are not as common, it's important to monitor them and seek medical advice if they become bothersome or severe.

Serious side effects, though rare, require immediate medical attention. These include dangerous sleep behaviors such as sleepwalking or sleep driving, slowed brain activity leading to excessive sleepiness or confusion, and respiratory issues like trouble breathing. Additionally, a serious allergic reaction may present with symptoms such as a rash, swelling of the face, tongue, or throat, and trouble breathing. Suicidal thoughts and behavior are also considered serious and warrant urgent medical care. If you experience any of these severe effects, it is crucial to seek medical help promptly to ensure your safety and well-being.

Zolpidem can interact with several other medications and substances, so it's important to inform your doctor or pharmacist about all medications, including prescription, over-the-counter, and herbal supplements, that you are currently using.

A notable interaction is with sodium oxybate and related compounds like calcium, magnesium, and potassium oxybate, which should generally be avoided. Additionally, medications such as certain azole antifungals (e.g., ketoconazole), rifampin, and St. John's Wort can affect how your body processes zolpidem, potentially altering its effectiveness.

Combining zolpidem with other substances that can cause drowsiness or breathing difficulties may increase the risk of severe side effects, such as slow or shallow breathing and extreme drowsiness. This includes opioid pain or cough medications (like codeine and hydrocodone), alcohol, cannabis, other sleep or anxiety medications (such as alprazolam, lorazepam, and zopiclone), muscle relaxants (such as carisoprodol and cyclobenzaprine), and some antihistamines (like cetirizine and diphenhydramine).

Always check the labels of all your medications, especially those for allergies or colds, as they might contain ingredients that can increase drowsiness. Consult your pharmacist for guidance on how to use these products safely.