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You might experience some mild side effects such as drowsiness, dizziness, constipation, stomach upset, blurred vision, or a dry mouth, nose, or throat. These are generally not serious and can often be managed with simple remedies. For instance, to alleviate dry mouth, try sucking on sugarless hard candy or ice chips, chewing sugarless gum, drinking water, or using a saliva substitute.

Although most people do not experience severe side effects, it's important to be aware of them. Contact your healthcare provider immediately if you notice any serious symptoms such as mental or mood changes, difficulty urinating, or a fast or irregular heartbeat. These require prompt attention to ensure your safety.

In rare cases, severe side effects such as seizures or a serious allergic reaction can occur. Symptoms of a severe allergic reaction include rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, or trouble breathing. If you experience any of these symptoms, seek medical help right away.

While this list includes several potential side effects, there may be others. If you observe any unusual changes in your health, it's best to consult your healthcare provider for guidance.

Some products that can interact with this medication include skin-applied antihistamines (like diphenhydramine in creams, ointments, or sprays). Inform your doctor or pharmacist if you are using other substances that can induce drowsiness, such as opioid pain relievers or cough suppressants (like codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (like Alprazolam, Lorazepam, Zolpidem), muscle relaxants (like Carisoprodol, Cyclobenzaprine), or other antihistamines (like Cetirizine, chlorpheniramine).

Be sure to check the labels of all your medications, including those for allergies or colds, since they may have ingredients that cause drowsiness. Consult your pharmacist to ensure safe use of these products. Additionally, this medication might affect certain lab tests (such as allergy skin tests), potentially leading to inaccurate results. Make sure laboratory staff and all your healthcare providers are aware that you are using this medication.