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When using aripiprazole, especially in combination with other medications for depression, it is crucial to thoroughly review the accompanying drug information for all medications involved. This medication is not recommended for treating dementia-related behavior issues due to the potential for serious and possibly fatal side effects, including stroke, heart failure, irregular heartbeat, and pneumonia, particularly in older adults with dementia. Therefore, it is important to discuss the risks and benefits of aripiprazole, as well as alternative treatments for dementia-related behavior problems, with your healthcare provider.

Key Safety Information:

• Increased Mortality in Dementia-Related Psychosis: Aripiprazole is not approved for treating psychosis related to dementia, as it may increase the risk of death due to heart issues, stroke, or infections. Notify your healthcare provider if dementia is present before starting this medication.

• Suicidal Thoughts in Youth: Children and young adults may experience an increased risk of suicidal thoughts and behaviors while on this medication, particularly during the initial months or when adjusting the dose. Caregivers should monitor for any behavioral changes and consult a provider if concerns arise.

• Neuroleptic Malignant Syndrome: This antipsychotic can cause a rare, life-threatening condition, characterized by high fever, stiff muscles, confusion, and irregular pulse. Immediate medical attention is required if these symptoms occur.

• Tardive Dyskinesia: Aripiprazole can lead to involuntary muscle movements, which may be permanent. The risk is higher in older adults, especially women, and those on long-term or high-dose antipsychotics. Report any uncontrollable movements to your provider.

• Metabolic Changes: The medication may cause high blood sugar, cholesterol, and weight gain. Those with diabetes or at risk should monitor blood sugar levels and report symptoms like excessive thirst or hunger.

• Impulse Control Problems: Some individuals may develop uncontrollable urges, such as gambling or binge eating. Notify your healthcare provider of any new compulsive behaviors.

• Risk of Falls and Low Blood Pressure: Aripiprazole can cause drowsiness and affect balance, increasing fall risk. Caution is advised, especially when using other blood pressure-lowering drugs.

• Low White Blood Cell Count: This medication may reduce white blood cell levels, elevating infection risk. Regular blood tests may be needed to monitor white blood cell counts, and any signs of infection should be promptly reported to a healthcare provider.

Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of aripiprazole.

This medication may cause a variety of side effects, some more common and mild, while others are rare and severe. Common side effects include headache, nausea, vomiting, dizziness, and drowsiness, which are often mild but should be discussed with a healthcare provider if persistent or worsening. Other common reactions can include constipation, restlessness, blurred vision, tiredness, and dry mouth. Patients may also experience agitation, anxiety, insomnia, and stomach discomfort.

In terms of more serious side effects, there are several that require immediate medical attention. These include symptoms of a stroke, such as trouble speaking, walking, or sudden confusion, and impulse-control problems like compulsive gambling or binge eating. Neuroleptic Malignant Syndrome (NMS) is a potentially life-threatening condition marked by high fever, muscle stiffness, confusion, and abnormal heart rhythms. Uncontrolled muscle movements, which may result in involuntary facial or limb actions, are also concerning.

Additionally, the medication can rarely lead to a significant increase in blood sugar levels, which could exacerbate diabetes. Signs of high blood sugar include increased hunger or thirst, frequent urination, and fruity-smelling breath. Serious infections may also occur, with symptoms like fever, sore throat, or difficulty breathing. Seizures are another rare but serious side effect. Allergic reactions, though rare, can be severe, presenting symptoms such as rash, swelling, or difficulty breathing. If any of these serious side effects occur, seeking urgent medical care is crucial.