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It is essential to be aware of the safety information and warnings associated with this medication to ensure its safe use and to prevent potential health risks. Below are important points to consider:

• Do Not Discontinue Abruptly: Do not stop taking this medication without consulting your healthcare provider, as some conditions may worsen abruptly. Individuals who have ceased similar medications suddenly have experienced serious heart issues, including chest pain, heart attacks, and irregular heartbeats. If your healthcare provider advises discontinuation, they will likely recommend a gradual reduction of the dose over 1 to 2 weeks. During this period, limit physical activity to reduce cardiac strain. Seek immediate medical attention if you experience chest pain, pressure, pain extending to the jaw, neck, or arm, unusual sweating, difficulty breathing, or a fast or irregular heartbeat.

• Liver Injury Risk: Rarely, severe liver injury, potentially leading to liver failure or death, has been reported by users of labetalol. Symptoms such as persistent itching, dark urine, weight loss, jaundice, abdominal pain, or unexplained flu-like symptoms should be promptly reported to your healthcare provider. Regular liver function monitoring may be recommended, and discontinuation of the drug may be necessary for some patients, particularly those with a history of liver issues.

• Heart Failure Concerns: Labetalol may cause or exacerbate heart failure by reducing heart rate and altering heart function. Individuals with a history of heart failure should consult their healthcare provider prior to use. Symptoms such as difficulty breathing, fatigue, swelling, or sudden weight gain require immediate medical attention, and discontinuation of the drug may be considered.

• Breathing Difficulties: This medication may constrict lung vessels, potentially causing breathing problems, especially in individuals with conditions like asthma or COPD. It is crucial to inform your healthcare provider of your full medical history before beginning treatment. The lowest effective dose will be initiated to minimize risks.

• Blood Sugar Monitoring: Labetalol can obscure symptoms of low blood sugar, such as rapid heartbeat or tremors, complicating diabetes management. Monitor for other signs like sweating. Patients with diabetes should discuss blood sugar monitoring frequency with their healthcare provider.

• Surgery Precautions: Inform your surgeon about labetalol use if you require major surgery with anesthesia, as it may increase anesthesia-related risks. Continued use might be allowed with careful heart monitoring.

• Drug Interactions: Avoid combining labetalol with specific calcium channel blockers, such as diltiazem or verapamil, as it may lead to dangerously low heart rates or heart block.

• Contraindications: Labetalol should not be used in individuals with low heart rates (less than 60 beats/minute), certain heart problems (such as severe heart block or cardiac shock), heart failure, uncontrolled severe asthma, or significantly low blood pressure. Always consult with your healthcare provider if you have these conditions before starting the medication.

By adhering to these guidelines and consulting your healthcare provider, you can use this medication more safely and effectively.

Common side effects:

• dizziness
• nausea
• tiredness
• indigestion
• stuffy nose
• headaches

Less common but important to monitor:

• general weakness
• vomiting
• diarrhea
• changes in taste
• tingling sensation
• drowsiness
• sexual dysfunction
• increased sweating
• swelling
• changes in vision

Serious side effects:

• worsening heart failure symptoms
• bronchospasm
• severe liver disease symptoms
• serious allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Albuterol
• Ceritinib
• Crizotinib
• Diltiazem
• Dronedarone
• Fenoldopam
• Fingolimod
• Verapamil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cimetidine
• Formoterol
• Halothane
• Indacaterol
• Iobenguane I 123
• Iobenguane I 131
• Iohexol
• Lacosamide
• Levalbuterol
• Olodaterol
• Oxymetazoline
• Ponesimod
• Rivastigmine
• Salmeterol
• Siponimod
• Terbutaline
• Vilanterol
• NSAIDs such as Ibuprofen and Naproxen