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The following safety information is crucial for anyone considering or currently using Zegerid (omeprazole / sodium bicarbonate). It outlines potential risks, necessary precautions, and specific instructions for certain populations. Please consult your healthcare provider if you have any questions or concerns.

• Monitoring Symptoms: If Zegerid alleviates your stomach-related symptoms but they recur, notify your healthcare provider. This could indicate a more serious condition, such as stomach cancer, requiring further medical evaluation.

• Kidney Damage: Users of PPIs like omeprazole have reported kidney damage, which can happen anytime during treatment. Symptoms like blood in urine, changes in urination, nausea, fever, or confusion require immediate cessation of the medication and consultation with a healthcare provider.

• Severe Skin Reactions: Although rare, severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis can occur. Seek prompt medical attention if you develop flu-like symptoms accompanied by a rash, blisters, or skin peeling.

• High Sodium Content: Zegerid contains sodium, which can cause swelling and weight gain. If you are on a low-sodium diet or have heart failure or high blood pressure, discuss this with your provider before use.

• Milk-Alkali Syndrome: This condition can disrupt your body's acid/base balance, particularly if Zegerid is used long-term or with calcium supplements or milk. Symptoms include nausea, frequent urination, headache, or dizziness, and should be discussed with your provider.

• Severe Diarrhea: There is a heightened risk of bacterial infection leading to severe diarrhea. If you experience watery diarrhea, fever, or persistent stomach pain, contact your healthcare provider immediately. Use the lowest effective dose for the shortest duration to minimize risk.

• Bone Fractures: Prolonged use or high doses of Zegerid may increase the risk of bone fractures. Your healthcare provider may recommend vitamin D and calcium supplements to support bone health.

• Lupus Risk: Though uncommon, PPIs like omeprazole can induce or exacerbate lupus. Symptoms vary, including joint pain or rash, and should improve within 1 to 3 months after discontinuation of Zegerid. Use the lowest effective dose for the shortest time to decrease risk.

• Drug Interactions: Zegerid may interact with numerous medications, vitamins, and supplements. For instance, it can alter the effectiveness of warfarin and certain HIV medications, and increase methotrexate levels. Inform your healthcare provider and pharmacist of all substances you are taking to assess for interactions.

• Low Vitamin B12 and Magnesium Levels: Prolonged use of Zegerid (over one year for magnesium, over three years for vitamin B12) can lead to deficiencies. Discuss with your provider if long-term use is necessary.

• Stomach Growths: Long-term use of Zegerid may increase the risk of small stomach growths, which are typically asymptomatic. Limit duration of treatment to reduce risk.

Contraindications: Avoid using Zegerid if you are taking rilpivirine-containing medications or if you have an allergy to benzimidazoles. Consult your healthcare provider for alternatives if these apply to you.

When taking this medication, some individuals might experience common side effects, which are generally mild. These include headaches, stomach pain, diarrhea, nausea, gas, and vomiting. If these symptoms persist or worsen, consult your healthcare provider for guidance.

There are additional side effects that may occur, such as upper respiratory infections (common colds), dizziness, rashes, constipation, and a general lack of energy. It is advisable to seek medical advice if these effects are significant or bothersome.

While rare, there are serious side effects that require immediate medical attention. These include severe diarrhea characterized by watery stool, fever, and persistent stomach pain, and serious kidney issues marked by blood in the urine or changes in urination frequency. Additionally, a severe skin reaction may manifest as fever, painful eyes, body aches, swallowing difficulties, and skin rashes or blisters.

Another severe concern is a significant drop in magnesium levels, which can lead to irregular heartbeats, muscle cramps, tremors, or seizures. Although a very serious allergic reaction is uncommon, symptoms such as fever, swollen lymph nodes, severe dizziness, and trouble breathing should prompt urgent medical care.

If you encounter any side effects not mentioned, or if you have concerns, contacting a healthcare professional is recommended for further advice and management.

Zegerid, which contains omeprazole and sodium bicarbonate, can interact with various medications and supplements. It's important to inform your doctor and pharmacist about all the medicines you're taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Certain medications, like rilpivirine, should not be used with Zegerid. Your doctor might decide not to prescribe this combination or adjust your treatments accordingly.

For other drugs, such as atazanavir, clopidogrel, erlotinib, methotrexate (especially at high doses), and memantine, using them with Zegerid is usually not recommended unless necessary. In such cases, your doctor may modify the dosage or frequency of either medication to manage potential interactions.

Moreover, Zegerid decreases stomach acid, which can affect the absorption of some drugs that require acidic conditions to be properly absorbed. This includes medications like atazanavir, erlotinib, and certain azole antifungals like itraconazole and ketoconazole.

Additionally, using Zegerid with drugs like digoxin, St John’s wort, or warfarin might increase the risk of side effects. If these combinations are required, your doctor will closely monitor your treatment and may adjust doses accordingly.

Avoid taking esomeprazole when on Zegerid, as both are similar and can lead to excessive medication levels. Lastly, Zegerid may interfere with some lab tests, leading to inaccurate results, so ensure all healthcare providers are aware of your Zegerid use.