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It is crucial to be aware of the safety information and warnings associated with the use of this medication. Below are key points to consider, and it is advised to consult your healthcare provider if you have any questions or concerns.

• Symptom Masking: Repeated heartburn could indicate stomach cancer. If your heartburn persists or worsens after taking dexlansoprazole (Dexilant), or if you experience poor appetite, unexplained weight loss, or weakness, consult your healthcare provider.

• Kidney Issues: Sudden kidney problems can occur with PPIs like dexlansoprazole (Dexilant) at any treatment stage. Symptoms such as changes in urination, nausea, weakness, fever, rash, or joint pain should be reported to your doctor.

• Infectious Diarrhea: PPIs may increase the risk of Clostridioides difficile infection, causing severe diarrhea, especially in older adults, those with recent hospital stays, or weakened immune systems. Use dexlansoprazole as prescribed and contact your doctor if you experience severe diarrhea, fever, abdominal pain, loss of appetite, or nausea.

• Bone Fractures: Long-term or high-dose use of dexlansoprazole (Dexilant) can increase the risk of fractures. Discuss with your healthcare provider if you have a history of fractures or osteoporosis.

• Skin Reactions: Serious skin reactions, like Stevens-Johnson syndrome or toxic epidermal necrolysis, are rare but possible. Seek immediate medical attention if you experience fever, rash, peeling skin, blisters, or facial swelling.

• Lupus: Dexlansoprazole (Dexilant) may cause new or worsening lupus symptoms, such as joint pain or rash. If symptoms occur, discontinue use and contact your healthcare provider.

• Vitamin B12 and Magnesium Deficiency: Prolonged use can lead to deficiencies in vitamin B12 and magnesium. If you've been on this medication for over three years or notice symptoms like dizziness, muscle weakness, pale skin, fatigue, or tingling, consult your doctor.

• Drug Interactions: Certain drugs can alter dexlansoprazole (Dexilant) levels or efficacy. Avoid using St. John’s Wort and rifampin while on this medication.

• Contraindications: Avoid using this medication with rilpivirine-containing drugs like Edurant and Cabenuva due to potential serious health risks. Always consult your healthcare provider if you are using or considering these medications.

When taking Dexilant (dexlansoprazole), it's important to be aware of potential interactions with other medications, supplements, and certain health conditions. These interactions can affect how Dexilant works or increase the risk of side effects. Always inform your healthcare provider about all the substances you are currently using to ensure safe and effective treatment.

Drug Interactions:

• HIV Medications: Dexilant can reduce the effectiveness of certain HIV drugs, such as rilpivirine, Atazanavir, and nelfinavir. Combining these medications may lead to decreased HIV treatment efficacy.

• Seizure Medications: Medications like Carbamazepine and Phenytoin may decrease the effectiveness of Dexilant. This could result in inadequate acid suppression.

• Antifungal Agents: Drugs such as Itraconazole, Ketoconazole, and Voriconazole may become less effective when taken with Dexilant. This interaction can compromise the treatment of fungal infections.

• Cancer Treatments: Medications like dasatinib, Erlotinib, and nilotinib may have reduced effectiveness when used concurrently with Dexilant. This could impact cancer therapy outcomes.

• Digoxin: Taking Dexilant with digoxin can increase digoxin levels in the body, raising the risk of side effects such as nausea, vomiting, and irregular heartbeats.

• Methotrexate: Dexilant may elevate methotrexate levels, potentially leading to increased side effects like diarrhea, vomiting, and mouth ulcers.

• Mycophenolate Mofetil: This immunosuppressant may be less effective when taken with Dexilant, which could affect organ transplant outcomes.

• Tacrolimus: Combining Dexilant with tacrolimus can increase tacrolimus levels, heightening the risk of side effects such as kidney problems and high blood pressure.

• Warfarin: Dexilant may increase warfarin levels, leading to a higher risk of bleeding complications.

Health Condition Interactions:

• Liver Disease: Individuals with moderate liver problems should use Dexilant cautiously, as the medication may be removed from the body more slowly, increasing the risk of side effects.

• Low Magnesium Levels: Dexilant can cause or worsen low magnesium levels, which may lead to serious health issues like seizures or irregular heart rhythms.

• Osteoporosis: Long-term use of Dexilant may increase the risk of bone fractures, especially in older adults.

• Lupus: There have been rare reports of Dexilant causing new or worsening cases of lupus.

Alcohol Interaction:

While Dexilant is not known to interact directly with alcohol, consuming alcohol can worsen symptoms of gastroesophageal reflux disease (GERD) and erosive esophagitis, conditions that Dexilant is used to treat. Therefore, it's advisable to limit or avoid alcohol consumption during treatment.

Recommendations:

• Consult Your Healthcare Provider: Before starting Dexilant, discuss all medications, supplements, and health conditions with your doctor to assess potential interactions.

• Monitor for Side Effects: Be vigilant for any unusual symptoms and report them to your healthcare provider promptly.

• Regular Check-ups: Regular monitoring may be necessary to manage and mitigate potential interactions effectively.

By being informed and proactive, you can help ensure that Dexilant works effectively while minimizing the risk of adverse interactions.