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The following information provides essential safety warnings and precautions when using this medication. Please review these details carefully and consult your healthcare provider if you have any concerns or questions.

• Risk of Masking Serious Conditions: Frequent heartburn may indicate a more severe condition such as stomach cancer. If your heartburn worsens or returns after taking omeprazole (Prilosec), or if you experience poor appetite, unexplained weight loss, or weakness, contact your healthcare provider to rule out other serious medical issues.

• Sudden Kidney Problems: Some individuals on PPIs like omeprazole (Prilosec) may experience sudden kidney issues during treatment. Seek medical advice if you notice changes in urination, nausea, weakness, fever, rash, or joint pain.

• Severe Infectious Diarrhea: Long-term use of PPIs, including omeprazole (Prilosec), can increase the risk of Clostridioides difficile (C. diff) infection, causing severe diarrhea. Those over 65, recent hospital or nursing home residents, or individuals with weakened immune systems are at higher risk. Use the smallest effective dose for the shortest time necessary and contact your healthcare provider if you experience severe diarrhea or other related symptoms.

• Bone Fractures: Prolonged use of PPIs like omeprazole (Prilosec) may elevate the risk of fractures in the hip, wrist, or spine, especially with high doses or long-term use. Discuss your risk with your healthcare provider if you have a history of bone fractures or osteoporosis.

• Serious Skin Reactions: Rarely, PPIs such as omeprazole (Prilosec) may cause severe skin reactions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Symptoms include fever, body aches, rash, peeling skin, painful blisters, and facial swelling. Seek immediate medical attention if these occur.

• Lupus: Omeprazole (Prilosec) can trigger new or worsening lupus symptoms. These symptoms usually improve within 1 to 3 months after stopping the medication. If you notice joint pain or a rash, discontinue use and consult your healthcare provider.

• Low Vitamin B12 and Magnesium Levels: Long-term use of omeprazole (Prilosec) may decrease vitamin B12 and magnesium levels. If used for more than 3 years, or if symptoms of deficiency such as dizziness, muscle weakness, or tingling occur, consult your prescriber.

• Drug Interactions: Some medications, like St. John's wort and rifampin (Rifadin), may alter the effectiveness of omeprazole (Prilosec). Avoid these drugs to prevent reduced efficacy or increased side effects.

• Inaccurate Lab Results: Omeprazole (Prilosec) may interfere with certain tumor screenings, potentially leading to inaccurate results. Discuss your medication use with your healthcare provider before undergoing testing, as you may need to pause omeprazole (Prilosec) two weeks before your tests.

Contraindications: Do not use this medication if you have a history of allergy to PPIs or if you are receiving Edurant (rilpivirine) or rilpivirine-containing medications (e.g., Complera). Consult your healthcare provider if these conditions apply to you.

When taking this medication, some common side effects may occur, such as headaches, abdominal pain, nausea, diarrhea, vomiting, and gas. These effects are generally mild but should be reported to a healthcare provider if they persist or worsen.

In some cases, users have experienced respiratory issues, fever, or ear infections. Although these are not as common, it is important to inform your healthcare provider if you experience any of these symptoms, particularly if they become severe.

There are rare but serious side effects that require immediate attention, including symptoms of low magnesium levels (muscle spasms, irregular heartbeat, seizures), signs of lupus (rash on the nose and cheeks, joint pain), and kidney problems (changes in urine output, pink or bloody urine). Additionally, a severe intestinal condition caused by C. difficile bacteria can occur during or after treatment, characterized by persistent diarrhea, stomach pain, and blood in the stool.

Long-term use of proton pump inhibitors like omeprazole can occasionally lead to vitamin B-12 deficiency, presenting as unusual weakness, a sore tongue, or numbness in the hands and feet. A serious allergic reaction is rare but requires urgent medical care if symptoms like fever, swollen lymph nodes, rash, swelling, severe dizziness, or trouble breathing occur.

If you notice any other unusual effects, it’s important to contact your healthcare provider for guidance.

Omeprazole can interact with several medications, which may alter how these medicines work or increase the risk of side effects. It's important to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Some drugs that should not be combined with omeprazole include rilpivirine, as the interaction is not recommended. Additionally, medications like clopidogrel, methotrexate (especially in high doses), and St John's wort may require careful monitoring if used with omeprazole. The interaction could affect how well these drugs perform or increase side effects.

Omeprazole reduces stomach acid, which can impact the absorption of certain drugs that need acid to be absorbed properly. Examples include atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, and rilpivirine. It's also advised to avoid taking esomeprazole with omeprazole due to their similarity.

Lastly, omeprazole may interfere with certain lab tests, leading to inaccurate results. Make sure to inform your healthcare providers and lab personnel that you are using omeprazole.