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Naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID), presents certain risks and requires careful use. Below are the key safety considerations and warnings associated with its use. Consult your healthcare provider for personalized advice.

• Heart Risks: Using naproxen sodium may increase the risk of heart attack or stroke, especially with prolonged use. This risk is higher in older adults and those with heart disease or risk factors such as smoking, high blood pressure, or diabetes. Avoid using this medication right before or after heart bypass surgery (CABG). Seek immediate medical attention if you experience chest pain, shortness of breath, or weakness on one side of the body.

• Gastrointestinal Bleeding: There is a risk of serious, potentially fatal bleeding from the stomach or intestines, which can occur without warning. This risk increases for older adults, individuals with a history of stomach bleeding or liver problems, and those consuming alcohol or smoking. If you experience severe stomach pain, black or tarry stools, or vomit that resembles coffee grounds, contact a healthcare provider immediately.

• Blood Pressure and Heart Failure: Naproxen sodium can cause fluid retention, raising blood pressure or leading to heart failure. Discuss with your healthcare provider if you have a history of heart problems or are on blood pressure medication. Monitor for symptoms like unexplained fainting or chest pain during physical activity.

• Kidney Health: This medication can affect kidney function, with higher risk in older adults, those with diabetes, or individuals taking other medications that affect the kidneys. Regular kidney function tests may be necessary during treatment. Report symptoms such as changes in urination or muscle cramps to your healthcare provider.

• Liver Concerns: Though rare, severe liver problems can occur. If you notice symptoms such as stomach swelling, yellowing of the skin or eyes, or dark urine, seek medical help immediately.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, may occur. Avoid if you have known allergies to aspirin or other NSAIDs. Symptoms like hives, rash, or difficulty breathing require urgent medical attention.

• Pregnancy and Breastfeeding: Naproxen sodium can harm an unborn baby, particularly after 20 weeks of pregnancy, and may cause complications. Discuss alternatives with your healthcare provider if you are pregnant or breastfeeding.

• Contraindications: Do not use naproxen sodium if you have a history of asthma or allergic reactions to aspirin or other NSAIDs, or if undergoing or recovering from heart bypass surgery (CABG).

Always discuss your medical history and current medications with your healthcare provider to evaluate the risks and benefits of using naproxen sodium.

When using this medication, some people may experience common side effects such as upset stomach, heartburn, nausea, headache, dizziness, drowsiness, constipation, itchy skin, and mild bruising. These effects are generally mild, but if they persist or worsen, it's important to consult your healthcare provider.

More serious side effects, although rare, require immediate medical attention. These include severe allergic reactions characterized by fever, swollen lymph nodes, rash, or swelling of the face, tongue, or throat. Symptoms of a serious allergic reaction can also include severe dizziness and difficulty breathing. Additionally, this medication can cause serious liver problems. Seek urgent medical help if you notice symptoms such as persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, or dark urine.

Heart-related side effects like high blood pressure, heart attack, stroke, or heart failure can also occur, although they are uncommon. Signs of these conditions include chest pain, trouble breathing, swelling, or unusual tiredness. If you experience any of these symptoms, immediate medical intervention is crucial.

Kidney problems may manifest as changes in urination, fatigue, or muscle cramps, and can also be serious. Furthermore, any changes in hearing or vision, or symptoms of stomach bleeding such as vomiting blood, should be met with prompt medical attention. Always monitor your health when taking this medication and report any unusual symptoms to your healthcare provider.

When taking Naproxen, it's important to be aware of potential drug interactions. This medication can interact with several other drugs, including Aliskiren, ACE inhibitors like Captopril and Lisinopril, and angiotensin II receptor blockers such as Losartan and Valsartan. It can also interact with Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics such as Furosemide. These interactions may require your doctor to adjust your medication regimen.

Naproxen may increase the risk of bleeding if used with other medications that can also cause bleeding. This includes anti-platelet drugs like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, and Warfarin. Additionally, it may reduce the effectiveness of low-dose Aspirin taken for heart attack or stroke prevention, so consult your doctor about the risks and benefits of continuing aspirin use.

Be cautious of over-the-counter medications for pain and fever, as many contain NSAIDs like Ibuprofen or Ketorolac, which can increase the risk of side effects if taken with naproxen. Your healthcare provider can recommend alternative treatments for pain or fever.

This medication can interfere with certain laboratory tests, potentially leading to inaccurate results. Ensure that all your healthcare providers and lab personnel are informed that you are using naproxen to avoid misinterpretations.

It is crucial to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to manage potential interactions effectively.