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This document outlines essential safety information and warnings related to the use of Androderm (testosterone patch). It is important to carefully review these details and discuss any questions or concerns with your healthcare provider.

• Increased Red Blood Cell Count and Cardiovascular Risks: Androderm may elevate your red blood cell (RBC) count, potentially increasing the risk of blood clots, heart attacks, or strokes. Regular blood tests will be conducted to monitor your RBC levels. If the count is too high, your doctor may advise pausing the treatment. Those with a history of heart conditions should be particularly cautious.

• Blood Clot Risks: There have been occurrences of blood clots in the legs or lungs associated with Androderm. Symptoms include leg pain, swelling, redness, difficulty breathing, or chest pain. Immediate medical attention is required if these symptoms occur.

• Potential for Misuse and Addiction: Androderm is a controlled substance due to its potential for misuse and addiction, especially if used in higher doses or combined with other testosterone products. Follow your prescription strictly to minimize these risks.

• Prostate Health Concerns: Androderm can exacerbate symptoms of an enlarged prostate or prostate cancer. Watch for changes in urinary patterns, such as increased frequency or difficulty urinating, and report them to your healthcare provider. Those with a history of prostate conditions should exercise caution.

• Liver Health: While Androderm itself is not known to cause liver issues, long-term use of certain testosterone forms can lead to serious liver damage. Be vigilant for signs like abdominal pain, pale stools, dark urine, or jaundice, and inform your care team if they occur.

• Fertility Impact: The use of Androderm can reduce sperm count, potentially affecting fertility. Discuss family planning with your doctor before starting treatment.

• Edema (Swelling): Androderm may cause fluid retention, leading to swelling in the legs or arms, which can be aggravated by other medications or conditions affecting the heart, liver, or kidneys. Consult your prescriber if swelling occurs.

• Sleep Apnea Worsening: Individuals with sleep apnea or a history of obesity or lung disease, such as asthma or COPD, might experience worsening symptoms with Androderm. Report increased daytime drowsiness or breathing interruptions during sleep to your doctor.

• Hypercalcemia (High Calcium Levels): The medication may raise blood calcium levels, especially in cancer patients or those on calcium-raising medications. Symptoms like muscle weakness, frequent urination, or stomach pain should prompt immediate medical consultation. Regular blood tests may be necessary.

Contraindications: Androderm should not be used by males with breast or prostate cancer, or by those who are currently pregnant, due to significant health risks. Always consult your healthcare provider if you fall into any of these categories before starting treatment.

When using this medication, it's important to be aware of potential side effects. Commonly, you might experience mild issues such as itchiness at the application site, which affects about 17% of users, or less frequently, blisters and back pain, each affecting around 6% of users. Although these are generally not serious, it's advisable to monitor them and consult with a healthcare professional if they continue or worsen.

Additionally, other side effects may occur, including application site redness, chills, diarrhea, fatigue, headaches, or acid reflux. Some users may notice bleeding into a joint, blood in the urine, increased urination frequency, or swelling of the prostate. While these are typically manageable, it's important to seek advice if they become troublesome.

There are also rare but severe side effects that require immediate medical attention. These include symptoms of a heart attack, such as chest pain and cold sweats, or signs of a stroke, like face drooping and difficulty speaking. Blood clots, which may present as leg pain or trouble breathing, are also serious. Withdrawal symptoms, liver damage indicators like stomach pain and jaundice, and significant hormonal changes can occur, necessitating urgent care. Always prioritize your health and seek prompt medical help if you experience any severe symptoms.