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Opium/belladonna carries several important safety warnings and precautions due to its potential risks. Below is a summary of the key information you need to be aware of if you are using this medication:

• Risk of Abuse and Addiction: Opium/belladonna has a high potential for abuse and addiction, which can result in overdose and potentially fatal outcomes. It is crucial to use the smallest effective dose for the shortest duration necessary as prescribed by your healthcare provider.

• Severe Breathing Problems: This medication can cause serious, possibly life-threatening breathing issues, especially when starting treatment, increasing the dose, or using an incorrect dose. The risk is heightened when combined with alcohol or other substances that cause drowsiness or respiratory depression. Be informed on which substances to avoid.

• Overdose Management: It is advisable to have naloxone available to counteract opioid overdose effects. Educate your family and household members on recognizing overdose symptoms and administering treatment if needed. Seek immediate medical assistance if you experience slow or shallow breathing, unusual lightheadedness, extreme drowsiness, or difficulty waking up.

• Safe Storage: Store this medication securely to prevent theft, misuse, or accidental ingestion. Immediate medical intervention is necessary if someone accidentally ingests the medication.

• Use During Pregnancy: Women of childbearing age should discuss the use of opium/belladonna with their doctor due to potential risks. If pregnant or planning pregnancy, only use this medication when absolutely necessary to minimize potential birth defects, especially in the first trimester. Prolonged use near delivery can harm the baby, and newborns may suffer severe withdrawal symptoms. Report symptoms such as persistent crying, breathing difficulties, irritability, or feeding challenges in newborns to a healthcare provider immediately.

Always consult your healthcare provider for personalized advice and ensure you understand how to use this medication safely and effectively.

Common side effects:

• nausea
• vomiting
• constipation
• blurred vision
• light sensitivity
• lightheadedness
• dizziness
• drowsiness
• changes in sweating
• dry mouth

Less common but important to monitor:

• mental changes like agitation or hallucinations
• difficulty urinating
• fainting
• irregular heartbeat
• eye pain
• vision changes
• loss of appetite
• unusual fatigue
• weight loss

Serious side effects:

• intense abdominal pain
• seizures
• slow or shallow breathing
• severe drowsiness that makes waking difficult
• serious allergic reactions characterized by rash, swelling, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Other opioid painkillers (such as codeine, hydrocodone) - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.
• Alcohol - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.
• Cannabis (marijuana) - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.
• Medications for sleep or anxiety (such as Alprazolam, Lorazepam, Zolpidem) - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.
• Muscle relaxants (such as Carisoprodol, Cyclobenzaprine) - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.
• Antihistamines (such as Cetirizine, diphenhydramine) - increased risk of serious side effects like slow/shallow breathing and severe drowsiness/dizziness.

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Mixed opioid agonist-antagonists (such as Butorphanol, Nalbuphine, pentazocine)
• Cimetidine
• Naltrexone
• Potassium supplements
• Pramlintide
• Rifampin
• Samidorphan