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No, COMBIGAN eye drops do not need to be shaken before use.

The cost of Combigan can be attributed to several factors, including the research and development expenses involved in creating the medication, the costs associated with clinical trials, and the regulatory processes required for approval. Additionally, market exclusivity and patent protection can limit competition, allowing the manufacturer to set higher prices. Manufacturing and distribution costs, as well as the pricing strategies of pharmaceutical companies, also play a role in the overall expense of the medication.

Combigan eye drops are used to lower elevated intraocular pressure in individuals with open-angle glaucoma or ocular hypertension. They contain a combination of brimonidine and timolol, which work together to reduce pressure inside the eye and help prevent damage to the optic nerve.

Combigan may be covered by Medicare Part D or Medicare Advantage plans that include prescription drug coverage. Coverage can vary depending on the specific plan, so it is advisable for the individual to check with their specific Medicare plan provider to confirm if Combigan is included in their formulary and to understand any associated costs or restrictions.

Long-term use of COMBIGAN, which is a combination of brimonidine and timolol, may lead to several side effects. These can include:- Eye irritation or discomfort- Dry eyes- Blurred vision- Changes in vision- Fatigue- Headache- DrowsinessIn some cases, more serious side effects may occur, such as:- Changes in heart rate or blood pressure- Respiratory issues, particularly in individuals with pre-existing conditions like asthma- Depression or mood changesIt is important for individuals using COMBIGAN to have regular follow-ups with their healthcare provider to monitor for any adverse effects.