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The safety and warning information for Combigan (brimonidine/timolol) eye drops is crucial for ensuring proper use and minimizing potential risks. Please carefully consider the following points and consult your healthcare provider if you have any questions or concerns:

• Application: Combigan eye drops are intended solely for ophthalmic use. Administer the drops only on the eye's surface and avoid contact between the bottle tip and any surface to prevent contamination. Do not ingest or inject this medication.

• Allergic Reactions: Some individuals may experience allergic reactions to brimonidine, even after prolonged use. Symptoms such as eye itchiness, watery eyes, or eyelid swelling should be reported to your healthcare provider immediately.

• Drug Interactions: The timolol component may interfere with the effectiveness of inhaled beta agonists, such as albuterol and levalbuterol, used for asthma or COPD. This could potentially reduce their ability to alleviate breathing difficulties. Inform your healthcare team if you have asthma or COPD.

• Heart Conditions: Timolol may be absorbed into the body and could exacerbate heart conditions by reducing heart rate and blood pressure. Notify your healthcare provider if you have a history of heart problems, and seek immediate medical attention if you experience symptoms such as shortness of breath or swelling in the extremities.

• Other Medical Conditions: Combigan may worsen conditions related to blood flow and muscle weakness. Discuss your medical history, including any serious allergies, vascular issues, depression, or muscle weakness, with your healthcare provider.

• Diabetes and Low Blood Sugar: Timolol can obscure signs of hypoglycemia, such as a fast heartbeat. Individuals with diabetes should monitor their blood sugar levels closely and be aware of hypoglycemia symptoms, seeking medical help if they occur.

• Hyperthyroidism: Symptoms of hyperthyroidism, like rapid heart rate, may be masked by Combigan. Disclose any thyroid issues to your healthcare provider before beginning treatment.

Contraindications: Combigan should not be used in individuals with the following conditions:

• Breathing issues (e.g., asthma, COPD)
• Symptomatic heart failure
• Second or third-degree heart block
• Bradycardia (slow heart rate)
• Insufficient blood pumping by the heart
• Patients under 2 years of age
• Known allergy to brimonidine or timolol

Please consult your healthcare provider to ensure Combigan is safe and appropriate for your specific health needs.

When using this medication, some individuals may experience mild side effects such as temporary blurred vision, burning, stinging, or redness in the eyes, watery eyes, dry eyes, or a sensation as if something is in the eye. Headaches, dry mouth, dizziness, or drowsiness can also occur. These effects are generally mild and often temporary, but if they persist or worsen, it is wise to consult a healthcare provider.

More serious side effects, although less common, necessitate prompt attention. These include vision changes, increased sensitivity to light, eye pain or swelling, irregular heartbeat, muscle weakness, unusual fatigue, mood changes, or coldness and numbness in extremities. Swelling of the ankles or feet, sudden weight gain, and difficulty breathing should also be addressed immediately.

Severe side effects are rare but critical, requiring urgent medical help. Symptoms such as persistent dizziness, chest pain, one-sided weakness, speech difficulties, confusion, or fainting indicate the need for immediate care. Additionally, a serious allergic reaction, though uncommon, may present as a rash, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing.

It is important to be aware of these potential side effects and to seek medical advice if any concerning symptoms arise.