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When using nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, it's important to be aware of several safety considerations and potential risks. Below is a summary of key precautions and actions to take:

• Cardiovascular Risks: NSAIDs may rarely increase the risk of heart attack or stroke, which can occur at any point during treatment. The likelihood of these events is higher with long-term use, particularly in older adults or individuals with heart disease or risk factors like smoking, family history, high blood pressure, or diabetes. Avoid using this drug immediately before or after heart bypass surgery (CABG).

• Liver Risks with Acetaminophen: This medication contains acetaminophen, and excessive intake can lead to severe, potentially fatal liver damage. Do not exceed 4000 milligrams (4 grams) of acetaminophen per day for adults. Those with liver issues and children should use a lower dose. Consult your doctor or pharmacist to determine a safe dosage. Avoid using other medications containing acetaminophen without medical approval, as it is frequently found in both prescription and over-the-counter products.

• Overdose Warning: In case of acetaminophen overdose, seek immediate medical attention, even if no symptoms are present. Symptoms of overdose may include nausea, vomiting, loss of appetite, sweating, abdominal pain, fatigue, yellowing of the skin or eyes, and dark urine.

• Alcohol and Tobacco Use: Regular alcohol consumption, especially when combined with this medication, can harm the liver. Alcohol and tobacco use may also heighten the risk of stomach bleeding. It is advisable to avoid alcohol and quit smoking.

• Gastrointestinal Risks: This drug may rarely cause serious, sometimes fatal, bleeding in the stomach or intestines, which can occur without warning. The risk is greater for older adults. Discontinue use and seek medical assistance if you experience persistent stomach pain, black/tarry stools, vomit resembling coffee grounds, or other serious symptoms like chest pain, shortness of breath, or sudden changes in vision.

• Emergency Situations: Stop taking this medication and contact a healthcare provider immediately if you notice severe symptoms such as unexplained stomach pain, unusual stools, or vomiting that looks like coffee grounds.

For any concerns about using this medication, discuss the benefits and risks with your doctor or pharmacist.

When taking this medication, you may experience mild side effects such as upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These effects are common, and many individuals find them manageable. If any of these symptoms persist or intensify, it is important to consult a healthcare professional.

While using this medication, it is advisable to monitor your blood pressure regularly, as it may elevate. Notify a healthcare provider if you observe a significant increase. Although serious side effects are uncommon, be vigilant for signs such as easy bruising or bleeding, changes in hearing (like ringing in the ears), difficulty or pain when swallowing, mood or mental changes, alterations in vision, or an unexplained stiff neck. Additionally, symptoms indicating kidney issues, such as changes in urine output, or heart failure, such as swelling of the ankles or feet, unusual fatigue, or sudden weight gain, should be addressed promptly with a medical professional.

In rare instances, this medication can lead to severe liver disease. Seek immediate medical attention if you experience persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, or dark urine, as these may indicate liver damage. Although a very serious allergic reaction is rare, be aware of symptoms like fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, and seek immediate medical help if they occur.

This list does not cover all possible side effects. If you notice any other unusual symptoms, it is crucial to contact a healthcare provider for guidance.

This medication can interact with several other drugs, which may lead to serious side effects. Notable interactions include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Prednisone, Ketoconazole, levoketoconazole, Lithium, Methotrexate, and diuretics like Furosemide. Additionally, this drug can increase the risk of bleeding if used with other medications that also cause bleeding, such as Clopidogrel and blood thinners like Dabigatran, Enoxaparin, and Warfarin.

Be cautious with over-the-counter medications, as many contain pain relievers or fever reducers similar to ibuprofen, like Aspirin and NSAIDs such as Celecoxib, Ketorolac, or Naproxen. These could heighten the risk of side effects if combined. If your doctor advises low-dose aspirin for heart attack or stroke prevention (81-162 mg daily), continue as instructed unless told otherwise. Note that regular ibuprofen use might reduce aspirin's effectiveness in preventing heart attacks or strokes. Discuss alternatives for pain or fever management, such as Acetaminophen, with your doctor.

If you must take this medication with aspirin, opt for immediate-release aspirin instead of enteric-coated, and time your doses carefully—take this medication at least 8 hours before or at least 2 hours after your aspirin dose. Do not adjust the aspirin dose or any other medications without consulting your doctor.

This medication might also affect certain lab tests, leading to inaccurate results. Ensure all healthcare providers and lab personnel are aware of your medication use.