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Oxymorphone presents several important safety considerations that must be understood to minimize risks associated with its use. It is crucial to adhere to prescribed guidelines and consult healthcare professionals for any concerns.

• Risk of Abuse and Addiction: Oxymorphone is a controlled substance with potential for misuse and addiction. To mitigate this risk, it is advised to use the lowest effective dose for the shortest duration. Always follow the prescription instructions carefully and consult your healthcare provider before making any changes.

• Respiratory Depression: This medication can cause dangerously slow breathing, which can be life-threatening, especially at the beginning of treatment or when the dose is increased. The risk is heightened when used with alcohol or other drugs that depress the central nervous system.

• Overdose Risk: An overdose of oxymorphone can be fatal. Keep this medication out of reach of children, pets, and others who might accidentally ingest it. Symptoms of overdose include very slow breathing, extreme drowsiness, and cold or clammy skin. Have naloxone available and educate yourself and others on how to use it in case of an overdose.

• Interactions with Other Substances: Avoid consuming alcohol while taking oxymorphone, as it can lead to serious side effects like increased sedation and respiratory depression. Be cautious when using other medications that can cause drowsiness, such as benzodiazepines and muscle relaxants.

• Use During Pregnancy: Pregnant individuals should only use oxymorphone if absolutely necessary, as it can cause harm to the unborn baby, including dependency and withdrawal symptoms after birth.

• Physical Dependence and Withdrawal: Long-term use can lead to physical dependence, with withdrawal symptoms occurring if the medication is stopped abruptly. Tapering off the medication under medical supervision can help prevent these symptoms.

• Severe Allergic Reactions: Some individuals may experience serious allergic reactions, including swelling, hives, and difficulty breathing. Seek medical attention immediately if these occur.

• Low Blood Pressure and Adrenal Insufficiency: Oxymorphone may cause low blood pressure and adrenal insufficiency, particularly with long-term use. Symptoms include dizziness, fatigue, and nausea.

• Seizure Risk: If you have a history of seizures, oxymorphone may increase their frequency. Immediate medical help is necessary if a seizure occurs.

• Contraindications: This medication should not be used by individuals with severely impaired breathing, severe asthma, gastrointestinal obstructions, or moderate to severe liver disease. Always consult your healthcare provider if you have any of these conditions before taking oxymorphone.

In summary, while oxymorphone can be an effective pain management option, it carries significant risks that require careful management and consultation with healthcare professionals to ensure safe use.

Common side effects:

• nausea
• fever
• sleepiness
• vomiting
• itching
• headache
• dizziness
• increased sweating
• dry mouth
• constipation
• lightheadedness

Serious side effects:

• interrupted breathing during sleep (sleep apnea)
• significant mental or mood changes such as confusion or hallucinations
• severe abdominal pain
• vision changes
• abnormal heartbeat
• difficulty urinating
• symptoms indicating adrenal glands may not be functioning well, such as unusual tiredness or weight loss
• slow or shallow breathing
• fainting
• seizures
• severe drowsiness that makes waking up difficult
• allergic reactions characterized by rash, significant itching or swelling, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Nalmefene
• Naltrexone
• Safinamide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Butorphanol
• Nalbuphine
• Pentazocine
• Samidorphan
• Codeine
• Hydrocodone
• Alcohol
• Marijuana (cannabis)
• Alprazolam
• Lorazepam
• Zolpidem
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine