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Dexmethylphenidate (commonly known as Focalin) is a medication that requires careful consideration and adherence to prescribed guidelines due to its potential risks and side effects. Below is important safety information:

• Misuse and Dependence: This medication can be habit-forming and may lead to serious side effects like a rapid heartbeat, high blood pressure, anxiety, and aggressive behavior if misused. It is essential to take it exactly as prescribed to avoid the risk of dependence and withdrawal symptoms. Individuals with a history of substance or alcohol use disorder should exercise caution.

• Heart-related Risks: There have been cases of severe heart issues, such as sudden death, heart attack, and stroke, associated with the use of stimulant medications like dexmethylphenidate. It can also increase heart rate and blood pressure. Inform your healthcare provider of any pre-existing heart conditions to ensure the medication is safe for you. If you experience symptoms such as fainting, chest pain during physical activity, or an irregular heartbeat, contact your healthcare provider immediately.

• Behavioral and Mental Health Changes: Dexmethylphenidate may cause changes in mood or thoughts, including hallucinations and mania. It can exacerbate existing mood disorders or cause new symptoms. Report any unusual mental health symptoms to your provider as you might need to stop the medication.

• Prolonged Erection: Although rare, some users may experience prolonged and painful erections that may require medical treatment. Seek immediate medical attention if this occurs.

• Circulation Issues (Raynaud's Phenomenon): This medication might cause circulation problems, leading to symptoms like numbness or pain in the fingers and toes. Inform your healthcare provider if you notice any such symptoms.

• Growth Impact in Children: Prolonged use in children may temporarily slow growth. Regular monitoring of growth by the healthcare provider is advised, and treatment may be adjusted if necessary.

• Serotonin Syndrome: This potentially life-threatening condition occurs when there is too much serotonin in the brain, often when dexmethylphenidate is taken with other medications that increase serotonin levels. Be cautious of drug combinations, especially with antidepressants or migraine medications.

• Drug Interactions: Dexmethylphenidate can interact with various medications, particularly those for blood pressure and monoamine oxidase inhibitors (MAOIs). It's crucial to discuss all current medications, including over-the-counter drugs and supplements, with your healthcare provider.

Contraindications:

• Do not use if you have a severe allergy to methylphenidate-containing products.
• Avoid if you are currently using or have recently used MAOIs within the last 14 days.

This information is vital for ensuring safe use of dexmethylphenidate. Always consult your healthcare provider for any questions or concerns regarding your treatment.

Common side effects:

• Difficulty sleeping
• Nausea
• Stomach pain
• Headache
• Loss of appetite
• Weight loss
• Dizziness

Less common but important to monitor:

• Increase in blood pressure
• Coldness, numbness, pain, or skin discoloration in fingers or toes
• Unusual wounds
• Fast, pounding, or irregular heartbeat
• Mental or mood changes like agitation, aggression, or mood swings
• Uncontrolled muscle movements
• Sudden outbursts of words or sounds
• Blurred vision

Serious side effects:

• Fainting
• Seizures
• Symptoms of a heart attack (chest or jaw pain, shortness of breath)
• Stroke symptoms (weakness on one side of the body, trouble speaking)
• Painful or prolonged erection lasting four or more hours
• Serious allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Furazolidone
• Iproniazid
• Nialamide
• Ozanimod

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Desflurane
• Enflurane
• Halothane
• Iobenguane I 131
• Isoflurane
• Methoxyflurane
• Risperidone
• Sevoflurane