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Here is essential safety information regarding the use of clonidine ER (Kapvay). Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Cardiovascular Concerns: Clonidine ER (Kapvay) can lower norepinephrine, resulting in decreased blood pressure and slower heart rate. Individuals with a history of heart problems, kidney failure, fainting, or dehydration should be cautious. Monitor your blood pressure at home if advised by your healthcare provider. Be vigilant for symptoms of low blood pressure, such as dizziness or lightheadedness, and contact your prescriber immediately if they occur. Abruptly stopping clonidine ER (Kapvay) after long-term use may cause a "rebound" effect, leading to elevated blood pressure and symptoms like headache, rapid heart rate, nausea, chest tightness, or anxiety. Always consult your healthcare professional before discontinuing this medication to ensure a safe tapering process.

• Drowsiness and Dizziness: This medication may cause significant drowsiness and dizziness, particularly at higher doses. Such effects can impair your ability to think, react, and concentrate. The risk is heightened if combined with other drowsiness-inducing substances, including benzodiazepines, anxiety medications, muscle relaxants, sleep aids, or alcohol. Understand how clonidine ER (Kapvay) affects you before engaging in activities such as driving. Contact your healthcare team if you experience excessive sleepiness.

• Allergic Reactions: If you have previously experienced a skin rash from using the clonidine patch, inform your healthcare provider, as you may have a similar reaction to clonidine ER (Kapvay). Depending on the severity of any past reactions, alternative treatments might be recommended.

• Contraindications: Clonidine ER (Kapvay) should not be taken by individuals allergic to clonidine. If you have such an allergy, please discuss alternative options with your healthcare provider.

In case of an overdose or adverse reaction, seek emergency medical attention immediately. Your safety is paramount, and adhering to these guidelines will help manage the risks associated with clonidine ER (Kapvay).

When taking this medication, some individuals may experience mild side effects such as dizziness, lightheadedness, drowsiness, tiredness, stuffy nose, dry mouth, constipation, sleepiness, headache, fatigue, upper stomach pain, irritability, trouble sleeping, nightmares, mood changes, nausea, and low appetite. These are generally not serious, but if they persist or worsen, it's advisable to consult a healthcare provider. Simple measures like rising slowly from sitting or lying positions can help reduce dizziness and lightheadedness, while sipping water or using sugarless gum or candy might alleviate dry mouth.

More serious side effects, though rare, require immediate medical attention. These include symptoms of a severe allergic reaction such as trouble breathing, rash, or swelling of the face, tongue, or throat. Other severe side effects might include fainting, slow or irregular heartbeat, and significant mood changes like depression. Additionally, dangerously low blood pressure can occur, characterized by severe dizziness, feeling faint, tiredness, or confusion. If any of these symptoms arise, seek urgent medical care right away. Always report any other unexpected side effects to your healthcare provider to ensure your safety while using this medication.

When taking medications that may cause drowsiness, such as alcohol, marijuana, antihistamines (like Cetirizine or diphenhydramine), sleep aids or anxiety medications (such as Alprazolam, Diazepam, or Zolpidem), muscle relaxants, or opioid pain relievers (like codeine), it is important to inform your doctor or pharmacist. These substances can enhance drowsiness. Additionally, check the labels on all your medications—including those for allergies or cough-and-cold—since they might contain ingredients that can cause drowsiness. Consult your pharmacist on how to use these medications safely.

Certain products may also elevate your blood pressure. Inform your pharmacist about all products you are using, especially cough-and-cold medicines, diet aids, or NSAIDs like Ibuprofen or Naproxen, to ensure safe usage.

For Clonidine ER (Kapvay), it is crucial to notify your healthcare provider about all medications or supplements you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Clonidine ER may interact with various medications. Some interactions might require adjustments in dosages or frequency, such as with Acebutolol, Amitriptyline, Atenolol, and others listed. Additionally, combining Clonidine ER with medications like Cyclosporine or Fluphenazine may increase the risk of side effects, but sometimes both drugs are necessary. Your doctor will manage your treatment plan to optimize safety and efficacy.