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Antidepressant medications are utilized to manage various conditions, including depression and other mental health disorders. They can be crucial in preventing suicidal thoughts or attempts and offer significant benefits. However, research indicates that a small percentage of individuals, particularly those under 25, may experience a deterioration in depression, other mental health symptoms, or suicidal thoughts or attempts when using these medications. It is essential to discuss the potential risks and benefits of antidepressant therapy with a healthcare provider, especially for those under 25, regardless of whether the treatment is for a mental health condition.

Key Points to Consider:

• Monitor for any worsening of depression or other psychiatric symptoms.
• Be alert to unusual behavioral changes, such as suicidal thoughts or attempts, increased anxiety, panic attacks, sleep disturbances, irritability, aggressive behavior, impulsive actions, severe restlessness, or rapid speech.
• Pay particular attention to these symptoms when starting a new antidepressant or adjusting the dosage.
• Promptly communicate any concerning symptoms to your healthcare provider.

Careful monitoring and communication with a healthcare professional are vital, especially during the initial phases of treatment or when modifying the dosage.

You might experience some mild side effects such as nausea, drowsiness, dizziness, trouble sleeping, loss of appetite, weakness, dry mouth, sweating, blurred vision, and yawning. These are generally not serious and often decrease as your body adjusts to the medication. However, if they persist or worsen, it's important to inform your healthcare provider.

There are certain side effects that require immediate attention from your healthcare provider. These include shaking or tremors, restlessness, inability to stay still, decreased interest in sex, changes in sexual ability, numbness or tingling, easy bruising or bleeding, irregular heartbeat, muscle weakness or spasms, and seizures.

Some very serious side effects need urgent medical help. These include black stools, vomit resembling coffee grounds, eye pain or swelling, widened pupils, and vision changes like seeing rainbows around lights at night. The drug might increase serotonin levels, potentially leading to serotonin syndrome—a rare but critical condition. Symptoms include a fast heartbeat, hallucinations, loss of coordination, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, unexplained fever, and unusual agitation.

In rare cases, males may experience a painful or prolonged erection lasting over four hours, which requires immediate medical attention to prevent lasting damage. Additionally, though uncommon, a serious allergic reaction can occur, signaled by a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. If you experience any of these symptoms, seek medical help promptly. Always report any other unexpected side effects to your healthcare provider.

Certain medications can interact with this drug, so it’s important to be aware of them. Medications like Thioridazine, and those that can increase the risk of bleeding or bruising, such as antiplatelet drugs like Clopidogrel, NSAIDs like Ibuprofen or Naproxen, and blood thinners like Dabigatran or Warfarin, should be used with caution. Aspirin can also raise the risk of bleeding when taken with this medication, but if your doctor has advised you to take low-dose aspirin (81-162 mg daily) to prevent heart attacks or strokes, you should continue unless directed otherwise by your doctor. Consult your doctor or pharmacist for more guidance.

This drug may slow down the elimination of other medications from your body, potentially affecting their effectiveness. Medications that could be impacted include Atomoxetine, phenothiazines, Pimozide, Risperidone, Tamoxifen, Tetrabenazine, antiarrhythmics like Propafenone or Flecainide, and tricyclic antidepressants like Desipramine or Amitriptyline.

Avoid using MAO inhibitors (such as isocarboxazid, Linezolid, Metaxalone, and others) with this medication due to the risk of a serious, possibly fatal interaction. Most MAO inhibitors should not be taken for two weeks before and after using this medication. Your doctor can advise when it is safe to start or stop these medications.

The chance of developing serotonin syndrome or toxicity increases if you are taking other drugs that boost serotonin levels. These include street drugs like MDMA, St. John's wort, certain antidepressants (other SSRIs like Citalopram or Fluoxetine, SNRIs like Duloxetine or Venlafaxine), and Tryptophan. The risk is higher when starting or increasing these drugs.

Inform your doctor or pharmacist if you use other products that cause drowsiness, such as alcohol, marijuana, antihistamines (like Cetirizine or diphenhydramine), sleep or anxiety medications (like Alprazolam, Diazepam, or Zolpidem), muscle relaxants, and opioid pain relievers (like codeine).

Always check the labels of your medications, including over-the-counter products for allergies or colds, as they may have ingredients that cause drowsiness. Ask your pharmacist how to safely use these products.

Be aware that this medication might interfere with certain medical or lab tests, such as a brain scan for Parkinson's disease, possibly leading to inaccurate results. Ensure that all healthcare providers involved in your care are informed about your use of this medication.