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When taking adefovir dipivoxil (Hepsera), it is crucial to be aware of the potential risks and necessary precautions. Below are key points to ensure safe use of this medication:

• Worsening Hepatitis B: Do not discontinue adefovir dipivoxil unless advised by your healthcare provider. Stopping the medication can lead to a severe exacerbation of hepatitis B, which may worsen liver conditions, especially in those with existing liver damage. Regular blood tests are essential in the first three months after stopping to monitor liver health and HBV infection.

• HIV Co-infection Risks: Before starting adefovir dipivoxil, and while on it, your healthcare provider will test for HIV, as this medication is not intended for HIV treatment. If you are co-infected with HIV and HBV, using adefovir dipivoxil alone can lead to HIV drug resistance, complicating future treatment efforts. It's important to follow a treatment plan that addresses both infections effectively.

• Kidney Health: Long-term use of adefovir dipivoxil can cause kidney damage, particularly in individuals with pre-existing kidney issues or those taking other nephrotoxic drugs. Regular monitoring of kidney function through blood tests is necessary, and dosage adjustments may be required to minimize risks.

• Lactic Acidosis and Liver Problems: Though rare, severe conditions such as lactic acidosis and fatty liver disease may occur with nucleoside analogs like adefovir dipivoxil. These are more common in women, individuals with obesity, or those on long-term treatment. Symptoms include extreme tiredness, sudden weakness, fast or shallow breathing, and abdominal pain. Immediate medical attention is required if these symptoms appear.

• Emergency Situations: If you experience unusual weakness, dark urine, yellowing of the skin or eyes, severe stomach pain, or any signs of kidney issues such as changes in urination, seek medical help promptly.

By understanding these safety measures, you can work with your healthcare provider to manage your treatment effectively and minimize risks associated with adefovir dipivoxil.

When taking this medication, some individuals may experience mild side effects, including weakness or lack of energy, headaches, stomach pain, nausea, gas, diarrhea, and an upset stomach. These are generally not serious but should be discussed with a healthcare provider if they persist or worsen.

On rare occasions, more severe side effects can occur. These include signs of kidney problems, such as a change in the amount of urine, as well as symptoms of lactic acidosis, which may manifest as extreme tiredness, sudden weakness, fast and shallow breathing, loss of appetite, nausea, and vomiting. Liver problems are also serious and may present as tiredness and stomach pain.

An allergic reaction to this medication is highly uncommon, but medical help should be sought immediately if symptoms such as rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing occur. Always consult your healthcare provider if you experience any side effects, whether listed here or not.