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Hydrocodone is a medication with potential for misuse and addiction, which can result in overdose and even death. It may also lead to serious breathing issues. To minimize risks, it is important to take the smallest effective dose for the shortest duration as prescribed by your doctor. Here is a summary of important safety information and warnings associated with hydrocodone use:

• Addiction and Misuse Risk: Hydrocodone is a controlled substance with a high risk of addiction and misuse, especially for individuals with a history of substance use disorders or mental health conditions. Misuse can cause life-threatening side effects, such as dangerously slow breathing and overdose.

• Respiratory Depression: Hydrocodone can lead to dangerously slow breathing, particularly when starting the medication or after a dose increase. The risk is heightened in older adults, those with breathing problems, or when combined with alcohol or other sedatives.

• Opioid Overdose: Taking hydrocodone in higher doses or more frequently than prescribed increases the risk of overdose. Symptoms of overdose include slow breathing, extreme sleepiness, and cold or clammy skin. Keep naloxone available for emergencies and educate family members on its use.

• Interactions with Other Substances: Avoid alcohol and other medications that induce drowsiness or respiratory issues, such as benzodiazepines or muscle relaxants. These interactions can enhance side effects and lead to severe outcomes.

• Pregnancy Risks: Use of hydrocodone during pregnancy can harm the unborn child, potentially leading to withdrawal symptoms in newborns. Pregnant women should only use hydrocodone if absolutely necessary and under medical advice.

• Physical Dependence and Withdrawal: Long-term use may result in physical dependence, with withdrawal symptoms occurring if the medication is suddenly stopped. Gradual dose reduction under medical supervision is recommended to prevent withdrawal.

• Low Blood Pressure and Heart Rhythm Issues: Hydrocodone can cause low blood pressure, leading to dizziness or fainting, and in rare cases, QT prolongation, affecting heart rhythm. Patients with heart conditions or those on certain medications should exercise caution.

• Seizure Risk: Individuals with a history of seizures may experience an increased risk while taking hydrocodone. Immediate medical attention is required if a seizure occurs.

• Special Precautions: Keep this medication out of reach of children, pets, and others to prevent accidental ingestion or misuse. Do not crush, chew, or dissolve extended-release forms to avoid fatal overdose.

If you experience severe side effects, such as difficulty breathing, extreme drowsiness, or unusual lightheadedness, seek medical help immediately. Always consult your healthcare provider for guidance tailored to your health condition and medication regimen.

When taking this medication, some individuals may experience mild side effects such as nausea, constipation, vomiting, dizziness, headache, and drowsiness. These effects are generally not severe and may diminish over time as your body adjusts to the medication. However, if they persist or worsen, it's advisable to consult your healthcare provider. To manage constipation, consider increasing dietary fiber intake, drinking plenty of water, and engaging in regular exercise. A suitable laxative may also be beneficial; your pharmacist can provide recommendations. To minimize dizziness and lightheadedness, slowly rise from sitting or lying positions.

In rare cases, serious side effects can occur, which require immediate medical attention. These include sleep apnea, mental or mood changes like agitation or hallucinations, stomach or abdominal pain, difficulty urinating, and symptoms of adrenal insufficiency such as unusual tiredness or weight loss. Additionally, very serious side effects such as fainting, fast or irregular heartbeat, severe dizziness, seizures, slow or shallow breathing, or difficulty waking up necessitate urgent medical care.

While a serious allergic reaction to this medication is uncommon, prompt medical help is essential if you experience symptoms like rash, itching or swelling, especially on the face, tongue, or throat, severe dizziness, or trouble breathing. If you notice any other effects not mentioned, contact your healthcare provider for further advice.

When taking Hydrocodone ER, it's important to be aware of potential interactions with other medications or substances. Inform your doctor and pharmacist about all the medications, including over-the-counter drugs, vitamins, and supplements, that you are currently using.

Certain medications such as nalmefene, Naltrexone, and safinamide should not be combined with Hydrocodone ER, as these interactions are not advisable. Your doctor may choose to either avoid using them together or adjust your treatment plan accordingly.

Some other drugs, while generally not recommended to be used with Hydrocodone ER, might be necessary in specific situations. If prescribed together, your healthcare provider might modify the dosage or frequency of one or both medications. This includes a wide range of drugs such as azole antifungals (e.g., Ketoconazole), certain antibiotics (e.g., Erythromycin), seizure medications (e.g., Carbamazepine), and others like Ritonavir and Rifampin, which can impact how hydrocodone is metabolized in your body.

Combining Hydrocodone ER with substances that cause drowsiness or breathing issues, such as other opioids (e.g., Oxycodone), alcohol, marijuana, sleep or anxiety medications (e.g., Alprazolam, Lorazepam), muscle relaxants (e.g., Carisoprodol), and antihistamines (e.g., diphenhydramine), can increase the risk of serious side effects like severe drowsiness and respiratory problems. It's crucial to check medication labels, especially for allergy or cough-and-cold products, which may contain drowsiness-inducing ingredients. Consulting your pharmacist about the safe use of these products is advisable.

Additionally, Hydrocodone ER may interfere with certain laboratory tests, potentially leading to incorrect results. Ensure that your doctors and lab personnel are aware that you are taking this medication.