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Hydrocodone is associated with a risk of misuse and addiction, potentially resulting in overdose and death. It may also lead to severe, possibly life-threatening, respiratory issues. To minimize these risks, it is important to use the lowest effective dose for the shortest necessary duration under your doctor's guidance.

• Consider having naloxone on hand for opioid overdose emergencies, and educate your family on recognizing and responding to an overdose.
• The likelihood of serious respiratory problems is elevated when beginning treatment, after increasing the dose, or if an incorrect dose/strength is taken.
• Combining hydrocodone with alcohol or other substances that cause drowsiness or respiratory issues can result in severe side effects, including death.
• Some drugs can interfere with hydrocodone elimination, potentially altering its effectiveness. Ensure you understand the correct use of hydrocodone and know which medications to avoid.
• Seek immediate medical attention if you experience symptoms such as slow or shallow breathing, extreme lightheadedness, severe drowsiness or dizziness, or difficulty waking up.
• Do not crush, chew, or dissolve extended-release hydrocodone tablets, as doing so could lead to a fatal overdose.

For women of childbearing age, it is crucial to discuss the potential benefits and risks with a healthcare provider before using this medication. Inform your doctor if you are pregnant or planning to become pregnant. Hydrocodone should only be used during pregnancy when absolutely necessary, as it might slightly increase the risk of birth defects in early pregnancy and pose harm to the unborn child if used long-term or in high doses near delivery. Babies exposed to hydrocodone during pregnancy may experience severe withdrawal symptoms after birth. Contact a doctor immediately if you notice symptoms such as persistent crying, slow or shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight in your newborn.

Store this medication securely to prevent theft, misuse, or abuse. In the event of accidental ingestion, seek medical help immediately.

You may experience nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness when taking this medication. These side effects often improve as your body adjusts to the drug. To manage constipation, include dietary fiber in your meals, stay hydrated, and exercise regularly. A laxative might be necessary; consult your pharmacist for recommendations. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

Serious side effects are less common but require immediate attention. Contact your healthcare provider if you experience sleep apnea, mental or mood changes like agitation or hallucinations, stomach pain, difficulty urinating, or symptoms indicating adrenal gland issues such as loss of appetite and unusual tiredness. Seek urgent medical help for very serious side effects, including fainting, irregular heartbeat, severe dizziness, seizures, or difficulty waking up.

Allergic reactions are rare but can be severe. If you notice a rash, itching, swelling, or difficulty breathing, seek medical assistance immediately. This summary does not cover all possible side effects. If you experience other symptoms, consult your healthcare professional for advice.

Some medications that could interact with this drug include specific pain relievers like Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone and samidorphan. Other drugs might change how hydrocodone is processed in your body, which can influence its effectiveness. These include azole antifungals (e.g., Ketoconazole), macrolide antibiotics (e.g., Erythromycin), Mifepristone, certain HIV medications (e.g., tipranavir), rifamycins (e.g., Rifabutin, Rifampin), Ritonavir, and some seizure drugs like Carbamazepine and Phenytoin.

Taking this medication with others that cause drowsiness or breathing issues can heighten the risk of severe side effects, such as slow or shallow breathing and intense drowsiness or dizziness. Inform your healthcare provider if you are using other opioid pain or cough medications (like codeine or Oxycodone), alcohol, marijuana, sleep or anxiety drugs (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or antihistamines (such as Cetirizine or diphenhydramine).

Check all your medication labels, including those for allergies or cold remedies, as they may contain ingredients that cause drowsiness. Consult your pharmacist about the safe use of these products. Additionally, this drug might affect certain lab tests, like amylase or lipase levels, potentially leading to incorrect results. Ensure that all healthcare providers and lab staff are aware that you are taking this medication.