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Nonsteroidal anti-inflammatory drugs, such as ibuprofen, may infrequently raise the risk of heart attacks or strokes. This risk can arise at any point during use, but it is more pronounced with prolonged use. Individuals at a higher risk include older adults and those with pre-existing heart conditions or factors that increase heart disease risk, such as smoking, a family history of heart disease, high blood pressure, or diabetes. Avoid using this medication immediately before or after coronary artery bypass graft surgery (CABG).

There is a rare potential for ibuprofen to cause severe, sometimes fatal, bleeding in the stomach or intestines. This serious effect can occur suddenly and without warning at any time during treatment. Older adults are particularly susceptible to this risk.

Discontinue use and seek immediate medical attention if you experience any of the following uncommon yet serious symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, pain in the chest, jaw, or left arm, difficulty breathing, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

Consult with your doctor or pharmacist to thoroughly understand the benefits and risks associated with using ibuprofen.

You might experience mild effects such as an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are generally not serious, but if they persist or worsen, it’s important to inform a healthcare professional.

This medication can lead to an increase in blood pressure, so regular monitoring is advised. If your readings are high, consult with a healthcare provider.

Some serious side effects may occur, though they are less common. These include easy bruising or bleeding, changes in hearing, mood alterations, an unexplained stiff neck, or signs of kidney problems like a change in urine output. Also, watch for vision changes and symptoms of heart failure, such as swelling in the ankles or feet, unusual tiredness, or sudden weight gain.

In rare cases, this drug can cause severe liver disease. Urgent medical attention is needed if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach pain, or yellowing of the skin or eyes.

Allergic reactions are also rare but can be serious. Seek immediate help if you experience fever, swollen lymph nodes, rash, itching, swelling, severe dizziness, or difficulty breathing. If you notice any other unusual effects, contact a healthcare provider for advice.

Some medications that can interact with this drug include Aliskiren, ACE inhibitors (like Captopril or Lisinopril), angiotensin II receptor blockers (such as Losartan or Valsartan), Cidofovir, corticosteroids (like Prednisone), Lithium, and diuretics (commonly known as "water pills," such as Furosemide). This drug could increase bleeding risk when used with other medications that also cause bleeding, including anti-platelet drugs like Clopidogrel and "blood thinners" such as Dabigatran, Enoxaparin, or Warfarin.

Be sure to read both prescription and over-the-counter medication labels carefully, as many contain pain relievers or fever reducers like Aspirin and NSAIDs (such as Celecoxib, Ketorolac, or Naproxen), which are similar to ibuprofen and may elevate the risk of side effects if taken together. However, if your doctor has advised you to take low-dose aspirin to prevent heart attacks or strokes (usually 81-162 milligrams a day), continue taking it unless instructed otherwise by your doctor. Regular ibuprofen use can reduce aspirin's effectiveness in preventing heart attacks or strokes. Discuss with your doctor whether you should use an alternative like Acetaminophen for pain or fever. If you need to take ibuprofen, consult your doctor about taking immediate-release aspirin (not enteric-coated) while on ibuprofen. Ensure to take ibuprofen at least 8 hours before or 2 hours after your aspirin dose. Do not change your aspirin dosage or the way you take any medications without your doctor's approval.