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This safety information outlines potential risks and contraindications associated with the use of this medication. It is crucial to review these details and discuss any concerns with your healthcare provider.

• High Potassium Levels: Potassium citrate (Urocit-K) may increase potassium levels in the body, potentially leading to serious heart complications. This risk is elevated for individuals with chronic kidney disease, heart failure, those using other potassium-increasing medications, or potassium-based salt substitutes.

• Stomach Lining Damage: Though uncommon, potassium salts may harm the stomach lining, potentially causing bleeding and posing a life-threatening risk. This is more likely if you are taking medications that can damage the stomach or slow digestion.

Contraindications: Situations where this medication should not be used due to significant health risks include:

• Existing or potential high potassium levels.
• Specific digestive issues that could delay the passage of potassium citrate through the system.
• Presence of stomach ulcers.
• Active urinary tract infections.
• Certain kidney conditions.
• Concurrent use of anticholinergic medications.

Always consult your healthcare provider if any of these conditions apply to you before using this medication.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Stomach upset
• Loose bowel movements

Less common but important to monitor:

• Hyperkalemia
• Muscle cramps
• Weakness
• Severe dizziness
• Slow or irregular heartbeat
• Mental or mood changes (confusion or restlessness)
• Tingling of the hands or feet
• Unusually cold skin

Serious side effects:

• Serious stomach or intestinal problems (bleeding, blockage, or puncture)
• Abdominal swelling
• Black or bloody stools
• Severe stomach or abdominal pain
• Vomiting that resembles coffee grounds
• Serious allergic reaction (rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Potassium supplements including salt substitutes
• Potassium-sparing diuretics (including Amiloride, Spironolactone, and Triamterene)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• ACE inhibitors (e.g., Lisinopril)
• Angiotensin blockers (e.g., Losartan)
• Drospirenone
• Medications that slow down digestion (such as anticholinergics like belladonna and antispasmodics like oxybutynin)
• Strong opioid pain relievers like morphine
• Eplerenone
• Heart medications such as quinidine and Digoxin
• Lithium
• Pramlintide

Interactions with low risk that usually do not require a change in therapy:

• Antacids containing aluminum
• Aspirin and other salicylates like Salsalate