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Nausea, vomiting, diarrhea, dizziness, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. When this medication is first started, there is a chance an old kidney stone will be passed. Tell your doctor right away if you have any serious side effects, including: bone/joint aches, muscle cramps, stomach pain, confusion, fast/irregular heartbeat, unusual weakness, tingling/numbness of the hands/feet, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Some products that may interact with this drug include: aspirin, burosumab, digoxin, eplerenone, certain high blood pressure drugs (including ACE inhibitors such as lisinopril, ARBs such as valsartan), potassium supplements/salt substitutes, vitamin products (such as vitamin D, calcium), certain "water pills" (including potassium-sparing diuretics such as amiloride/spironolactone/triamterene). If your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.