Pretomanid

Pretomanid Coupons & Discount Card – Guaranteed Prices from $627.33

Pretomanid is an antibiotic used to treat a challenging type of tuberculosis (TB) infection in the lungs, specifically multi-drug-resistant TB in adults. It is administered in combination with two other medications, bedaquiline and linezolid, to effectively combat the infection. Pretomanid operates by inhibiting the growth and protective mechanisms of the TB-causing bacteria, thereby helping to eliminate the infection. It is important to note that this medication targets only bacterial infections and is not effective against viral infections like the common cold or flu. For optimal results, adherence to the prescribed regimen, possibly under a directly observed therapy (DOT) program, is essential. Always consult with your healthcare provider for advice tailored to your specific health needs.
Our coupons are free to use. Before paying, show the pharmacist your Pretomanid savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Pretomanid prices will update based on your prescription needs. Above our Pretomanid coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Pretomanid at the lowest price with our prescription discount card.

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200MG, Pretomanid (30 Tablets)

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CVS

$747.57

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Walgreens

$627.33

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Rite Aid

$722.39

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Walmart

$743.23

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Albertsons

$749.69

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Pretomanid savings card

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Walgreens

$627.33

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LHKEJ788414

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DR33

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Pretomanid dosage forms

The average cost for 30 Tablets of Pretomanid at 200MG is $741.94 with a free coupon. This is 72% off the average retail price of $2683.15
DosageQuantityPrice fromPer unit
200MG30 Tablets$741.94$24.73

Pretomanid Warnings

The following safety information outlines critical risks and precautions associated with the use of this medication. Carefully review these points and consult your healthcare provider if you have questions or concerns.

  • Liver Damage: The combination of pretomanid, Sirturo (bedaquiline), and linezolid (Zyvox) may cause liver damage. This risk is heightened if you have a history of liver issues but can occur in anyone. Regular blood tests will be conducted by your healthcare provider to monitor liver health. Avoid alcohol during treatment and inform your provider about all medications or supplements you're taking. Immediately report symptoms such as fatigue, appetite loss, nausea, vomiting, dark urine, right-side stomach pain, or yellowing of the eyes or skin, as these may indicate liver problems.

  • Low Blood Counts: Linezolid (Zyvox), often used with pretomanid and Sirturo (bedaquiline), can lower blood counts, increasing the risk of severe bleeding and infections. Your provider will monitor your blood counts and may adjust medication doses if needed. Seek immediate medical attention for persistent bleeding, infections, or fevers.

  • Heart Rhythm Problems: Sirturo (bedaquiline) can affect heart rhythms, potentially leading to QT prolongation, a serious condition. Low blood levels of calcium, magnesium, or potassium can also contribute to this risk. Your provider will perform regular heart scans (EKG) and blood tests to monitor these levels. Inform your provider about your complete medical history, as certain conditions may increase your risk. Seek emergency care if you experience a rapid heartbeat or fainting.

  • Nerve and Eye Problems (Peripheral and Optic Neuropathy): The use of pretomanid with Sirturo (bedaquiline) and linezolid (Zyvox) can cause nerve issues, affecting limbs and sometimes eyes. These effects, commonly associated with linezolid, may include numbness, burning sensations, tremors, balance issues, limb weakness, or vision changes. These symptoms are often reversible with dose adjustments. Notify your provider of any such symptoms, and if vision changes occur, an eye specialist consultation may be necessary.

Please ensure you communicate any health changes to your healthcare provider promptly and adhere to their instructions for monitoring and managing potential side effects.

Pretomanid Side Effects

Common side effects:

  • nausea
  • upset stomach
  • diarrhea
  • cough
  • muscle or joint pain
  • acne
  • headache
  • weakness
  • tingling or numbness in the hands and feet
  • low red blood cell count (anemia)

Less common but important to monitor:

  • higher liver enzymes
  • heartburn
  • low appetite
  • rash
  • itchiness
  • stomach pain
  • sharp chest pain
  • respiratory tract infections like bronchitis or pneumonia
  • coughing up blood
  • vision problems
  • low blood sugar
  • abnormal weight loss
  • constipation
  • dry skin
  • trouble sleeping

Serious side effects:

  • liver damage symptoms (dark urine, right-side stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting)
  • unexplained bleeding or bruising
  • low white blood cell count leading to repeated fevers or infections
  • abnormal heart rhythms like a fast heartbeat or fainting
  • serious allergic reaction symptoms (rash, itching or swelling of the face, tongue, or throat, severe dizziness, trouble breathing)

Pretomanid Interactions

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • efavirenz
  • rifamycins (such as rifampin, rifabutin)
  • St. John's wort
  • seizure medications (such as carbamazepine, phenytoin)
Pretomanid FAQs
What is the drug pretomanid used for?

Pretomanid is used in combination with bedaquiline and linezolid for the treatment of adults with extensively drug-resistant, treatment-intolerant, or non-responsive multidrug-resistant pulmonary tuberculosis.

Yes, pretomanid is FDA approved. It was approved by the U.S. Food and Drug Administration in August 2019 for use in combination with bedaquiline and linezolid for the treatment of a specific type of highly drug-resistant tuberculosis.

Pretomanid works by inhibiting the synthesis of mycolic acid, an essential component of the mycobacterial cell wall. Additionally, under anaerobic conditions, it releases nitric oxide, which contributes to its bactericidal activity against Mycobacterium tuberculosis. This dual action makes it effective in treating drug-resistant tuberculosis.

The generic name for pretomanid is pretomanid itself.

The FDA has approved several drugs for the treatment of tuberculosis. The first-line anti-tuberculosis medications include isoniazid, rifampin, ethambutol, and pyrazinamide. These drugs are typically used in combination to effectively treat active tuberculosis infections. Additionally, rifapentine and rifabutin are also approved for specific cases. Treatment regimens may vary based on the patient's condition and drug susceptibility testing.