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This medication may cause some common side effects, including diarrhea, nausea, vomiting, dizziness, lightheadedness, drowsiness, stomach upset, and loss of appetite. Some may experience trouble sleeping, headaches, or a dry mouth. While these effects are generally mild, consult your healthcare provider if they persist or worsen. Additionally, the medication can cause harmless discoloration of saliva, urine, or sweat, which may stain clothing.

To minimize dizziness and lightheadedness, it's advisable to rise slowly when moving from sitting or lying down. Although many individuals do not experience serious side effects, it's important to be aware of certain risks. Some users may suddenly fall asleep during daily activities, even without prior drowsiness. If you notice increased sleepiness or fall asleep unexpectedly, avoid driving or engaging in potentially dangerous tasks and discuss this with your healthcare provider.

Serious side effects require immediate attention, such as uncontrolled movements, severe stomach pain, vision changes, or symptoms of infection. Unusual urges, easy bruising, and strong fatigue are also concerning signs. Seek urgent medical help if you experience chest pain, fainting, or severe allergic reactions like rash or swelling. Stopping this medication abruptly can lead to neuroleptic malignant syndrome (NMS), characterized by symptoms like fever, muscle stiffness, and confusion. Always report any new or worsening effects to your healthcare provider for proper guidance.

This medication can interact with certain drugs, including those used to manage high blood pressure like methyldopa. It's important to avoid taking MAO inhibitors (such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, and tranylcypromine) with this medication due to the risk of a serious, potentially fatal interaction. Most MAO inhibitors should not be used for two weeks before starting treatment with this medication. However, some MAO inhibitors, such as rasagiline, safinamide, and selegiline, may be taken under close medical supervision. Consult your doctor about when it is safe to begin or discontinue this medication.

Additionally, inform your doctor or pharmacist if you are using other substances that cause drowsiness, including alcohol, marijuana, antihistamines (like cetirizine and diphenhydramine), sleep or anxiety medications (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol and cyclobenzaprine), and opioid pain relievers (including codeine and hydrocodone).

Be sure to read labels on all your medicines, especially allergy or cough-and-cold products, as they may contain components that cause drowsiness. Consult your pharmacist for advice on using these products safely.

Lastly, this medication might interfere with certain laboratory tests, such as urine tests for catecholamines, glucose, or ketones, potentially leading to inaccurate results. Ensure that all your healthcare providers and lab personnel are aware you are taking this medication.