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The use of this medication requires careful consideration due to its associated risks and necessary precautions. Below is a summary of the important safety information that should be reviewed by patients and healthcare professionals:

• Risk to Unborn Babies: This medication, Olmesartan (Benicar), can cause severe harm, possibly fatal, to unborn babies. It is crucial to avoid using this medication during pregnancy. If you are pregnant or planning to become pregnant, consult your healthcare provider immediately to discuss alternative treatments. If you discover you are pregnant while taking this medication, stop taking it and contact your provider without delay.

• Low Blood Pressure Concerns: Olmesartan lowers blood pressure, which can be particularly risky for individuals who are dehydrated or have lost significant body fluids due to diarrhea, vomiting, or the use of diuretics. Those with low salt levels or taking higher doses of diuretics should be cautious. Discuss with your healthcare provider if you fall into these categories.

• Kidney Function Impairment: This medication may worsen kidney function, especially in individuals with pre-existing kidney conditions, such as renal artery stenosis or severe heart failure, or those taking kidney-affecting medications. Regular blood tests may be required to monitor kidney health. Inform your provider if you notice reduced urination or swelling, which could indicate kidney issues.

• Elevated Potassium Levels: Olmesartan may increase potassium levels in the body, potentially causing symptoms like tingling, nausea, or muscle weakness. The risk is heightened if you are on other potassium-raising medications or have certain medical conditions. Regular potassium level monitoring through blood tests may be necessary.

• Severe Diarrhea (Sprue-like Enteropathy): Though rare, some individuals may experience severe diarrhea after months or years of using Olmesartan. This can lead to weight loss, abdominal pain, fatigue, nausea, and vomiting. Seek medical attention if you have persistent severe diarrhea, and ensure you remain hydrated.

• Contraindications: Do not use Olmesartan in conjunction with aliskiren (Tekturna) if you have diabetes, as it may pose serious health risks. Always consult with your healthcare provider if you have any underlying conditions or are taking other medications.

For any questions or concerns about your treatment, or in case of an emergency, contact your healthcare provider promptly for guidance.

Common side effects:

• dizziness
• lightheadedness

Less common but important to monitor:

• facial swelling
• weakness
• vomiting
• hair loss
• rash
• diarrhea

Serious side effects:

• severe kidney problems
• dangerously low blood pressure
• high potassium levels
• severe diarrhea
• very serious allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Aliskiren

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Benazepril
• Captopril
• Enalapril
• Enalaprilat
• Fosinopril
• Lisinopril
• Lithium
• Moexipril
• Perindopril
• Quinapril
• Ramipril
• Trandolapril
• Trimethoprim

Interactions with low risk that usually do not require a change in therapy:

• Ibuprofen
• Naproxen
• Bromfenac
• Bufexamac
• Celecoxib
• Choline Salicylate
• Clonixin
• Colesevelam
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Indomethacin
• Ketoprofen
• Ketorolac
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Morniflumate
• Nabumetone
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Piketoprofen
• Piroxicam
• Proglumetacin
• Propionic Acid
• Propyphenazone
• Proquazone
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sodium Salicylate
• Sulindac
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Valdecoxib