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It is important to be aware of the safety information and warnings associated with taking Lisinopril, especially if you are pregnant or have certain pre-existing conditions. Below are key points to consider:

• Pregnancy Warning: Lisinopril can cause severe harm or potentially fatal effects on an unborn baby. It is crucial not to use this medication during pregnancy. If you become pregnant while taking Lisinopril, stop the medication immediately and contact your healthcare provider. Discuss alternative treatments with your healthcare provider if you are planning to become pregnant.

• Angioedema Risk: This medication may cause angioedema, which is a serious condition characterized by swelling of the face, throat, or tongue, potentially leading to breathing difficulties. This risk is particularly higher in Black individuals and those with a history of angioedema. If you experience any swelling or breathing difficulties, seek immediate medical attention and discontinue use.

• Low Blood Pressure: Lisinopril can cause a significant drop in blood pressure, leading to dizziness or lightheadedness, especially when starting or increasing the dose. Stay hydrated and inform your healthcare team if you experience these symptoms. If a fall or head injury occurs, get medical help right away.

• Kidney Function: The medication may impair kidney function, particularly in individuals with pre-existing kidney issues or severe heart failure. Regular monitoring of kidney health through lab tests may be necessary. Alert your healthcare provider if you notice a decrease in urination.

• Electrolyte Imbalance: Changes in sodium, potassium, and magnesium levels can occur. Your healthcare provider may conduct blood tests to monitor these levels. Report symptoms like irregular heartbeat, muscle cramps, or nausea to your healthcare team.

• Vision Changes: Some individuals may experience changes in vision due to the hydrochlorothiazide component. Report any visual disturbances or eye pain immediately, as surgery might be needed to prevent permanent vision loss.

• Lupus: In rare instances, this medication may trigger or worsen lupus. Be aware of symptoms such as a rash on the face or extreme fatigue and report these to your provider.

• Contraindications: Lisinopril should not be used in conjunction with certain medications, such as aliskiren (in individuals with diabetes) or within 36 hours of neprilysin inhibitors like Entresto. It is also contraindicated for those with specific allergies, a history of angioedema, or if urine production is severely reduced.

If you have any questions or concerns about these warnings, consult your healthcare provider to ensure safe and effective use of this medication.

When taking this medication, some individuals might experience common side effects, including dizziness, headaches, and extreme tiredness. You may also feel lightheaded when standing up after sitting or lying down, or develop a dry cough. These side effects are generally mild and should improve as your body adjusts to the medication. If they persist or worsen, consult your healthcare provider.

Some users have reported experiencing other side effects such as chest or stomach pain, constipation, dry mouth, muscle cramps, lower sex drive, and ringing in the ears. Although these are less common, it is important to notify your healthcare provider if they occur.

There are rare but serious side effects that require immediate medical attention. These include angioedema, characterized by severe swelling of the face, arms, or legs; dangerously low blood pressure leading to dizziness and fainting; and serious kidney problems indicated by reduced urination and swelling in the extremities. Liver issues may manifest as yellowing skin or eyes, stomach pain, and persistent nausea or vomiting. Additionally, high blood potassium levels can cause nausea, muscle weakness, and an abnormal heartbeat. Be alert for severe allergic reactions, such as swelling of the lips, tongue, throat, or face, and difficulty breathing.

This medication might also lead to dehydration or an electrolyte imbalance, presenting as excessive thirst, muscle weakness, or irregular heartbeat. If you notice any symptoms not listed here, it’s crucial to contact your healthcare provider promptly.

When taking Zestoretic (lisinopril/hydrochlorothiazide), be aware of potential interactions with other medications. It is crucial to inform your healthcare provider and pharmacist about all medications and supplements you are using, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Certain medications should not be combined with Zestoretic. These include aliskiren, dofetilide, and sacubitril. Your doctor might choose to stop or adjust these medications if you're taking Zestoretic.

Other medications, while not usually recommended with Zestoretic, might be necessary in some situations. If both medications are prescribed, your doctor may adjust the dosages or administration schedule. Such medications include NSAIDs (like ibuprofen and naproxen), everolimus, sirolimus, lithium, and drugs that can increase blood potassium levels (such as ARBs like losartan or valsartan, and birth control pills containing drospirenone).

Moreover, using Zestoretic with certain medications may increase the risk of side effects but could still be the most suitable treatment option. In such cases, your doctor will monitor and possibly adjust your treatment plan.

Lastly, Zestoretic may interfere with some laboratory tests, potentially causing false results, such as in parathyroid function tests. Ensure that all healthcare professionals and lab staff are aware you are taking this medication.