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Antidepressants are prescribed to manage depression and various mental health disorders. They play a crucial role in reducing suicidal thoughts and providing therapeutic benefits. However, they may lead to an increase in depressive symptoms or suicidal tendencies in some individuals, particularly those under 25. It is essential to discuss the potential risks and benefits of these medications with a healthcare provider, especially for those under 25, regardless of the specific condition being treated.

• Be vigilant for worsening depression or any changes in mental health, such as unusual behavior, suicidal thoughts, or mood shifts.
• Report any new or worsening symptoms, including anxiety, panic attacks, insomnia, irritability, anger, impulsivity, severe restlessness, or rapid speech, to a healthcare professional immediately.
• Extra caution is necessary when initiating a new antidepressant regimen or altering the dosage.

Close monitoring and communication with a doctor can help manage these risks effectively.

You may experience some mild side effects such as nausea, drowsiness, dizziness, dry mouth, constipation, loss of appetite, blurred vision, nervousness, trouble sleeping, unusual sweating, or frequent yawning. These are typically not serious, but if they persist or worsen, consult your healthcare provider.

This medication can potentially raise your blood pressure, so it is important to monitor it regularly. Inform your healthcare provider if you notice any significant increases. Be attentive to more serious side effects, which may include easy bleeding or bruising, reduced interest in sex, changes in sexual function, muscle cramps or weakness, or tremors. Contact your healthcare provider promptly if you experience any of these.

Seek immediate medical assistance for very serious side effects, such as a persistent cough, shortness of breath, chest pain, severe headaches, black stools, vomit resembling coffee grounds, eye pain or swelling, widened pupils, changes in vision, or seizures. In rare cases, this medication may cause serotonin syndrome, a potentially life-threatening condition. Symptoms include a rapid heartbeat, hallucinations, coordination issues, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, unexplained fever, or agitation. If you notice these symptoms, seek medical help immediately.

Allergic reactions to this medication are rare but can be severe. Watch for signs such as a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. If these occur, seek emergency medical attention. If you experience any other side effects not mentioned here, contact your healthcare provider for further guidance.

Some medications and products can interact with this drug. These include drugs that may cause increased bleeding or bruising, such as antiplatelet medications like Clopidogrel, NSAIDs like Ibuprofen and Naproxen, and anticoagulants like Dabigatran and Warfarin. Aspirin can also raise the risk of bleeding if taken with this medication. However, if your doctor has recommended low-dose aspirin (typically 81-162 milligrams daily) to prevent heart attacks or strokes, continue using it unless advised otherwise by your doctor. Consult your doctor or pharmacist for further guidance.

Taking this medication with MAO inhibitors can lead to a serious, potentially life-threatening interaction. MAO inhibitors you should avoid include isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. Most MAO inhibitors should not be taken for two weeks before and at least seven days after using this drug. Confirm with your doctor when to start or stop any medications.

The risk of serotonin syndrome or toxicity can increase if you are also on medications that boost serotonin levels. These include certain antidepressants like SSRIs (e.g., Fluoxetine, paroxetine), other SNRIs (e.g., Duloxetine, milnacipran), Tryptophan, some recreational drugs like MDMA/ecstasy, and herbal supplements like St. John's wort. This risk may be higher when beginning or increasing the dose of these drugs.

Inform your doctor or pharmacist if you are using other products that cause drowsiness, such as opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine). Check the labels of all your medicines for drowsiness-causing ingredients and consult your pharmacist about safe use.

Venlafaxine is closely related to desvenlafaxine. Do not take desvenlafaxine-containing medications while using venlafaxine.

This drug may interfere with certain lab tests, including urine tests for amphetamines, possibly leading to incorrect results. Ensure that all lab personnel and your healthcare providers are aware that you are using this medication.