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Antidepressant medications, such as Vilazodone (Viibryd), are prescribed to treat conditions like depression and other mood disorders, providing important benefits, including the prevention of suicidal thoughts or attempts. However, there are essential safety and warning considerations to be aware of when using these medications:

• Suicidal Thoughts and Behavior: Antidepressants may increase the risk of suicidal thoughts or behaviors, particularly in individuals aged 24 or younger. Be vigilant for any worsening of depression or unusual changes in mood or behavior, especially during the initial treatment period or following a dosage change. Promptly report any concerning symptoms to your healthcare provider.

• Serotonin Syndrome: This rare but potentially life-threatening condition can occur if there is an excess of serotonin in the body, often when combined with other serotonergic drugs. Symptoms include a rapid heartbeat, sweating, muscle stiffness, fever, and confusion. Seek emergency medical attention if you experience any of these symptoms.

• Serious Bleeding: Vilazodone can increase the risk of bleeding, particularly if taken with other medications that also raise bleeding risks, such as NSAIDs, aspirin, and warfarin. Look out for signs such as persistent bruising, difficulty stopping bleeding, blood in urine, or dark stools, and inform your provider immediately.

• Low Sodium Levels (Hyponatremia): Be aware of symptoms like headaches, difficulty concentrating, memory issues, confusion, weakness, or unsteadiness, as these can indicate low sodium levels, which may lead to serious complications. Contact your provider if you have these symptoms.

• Eye Problems: Vilazodone may cause pupil dilation, potentially exacerbating conditions like angle-closure glaucoma. Report any eye pain, swelling, redness, or vision changes to your provider. An eye examination may be recommended if you have a history of eye conditions.

• Worsening of Mania or Hypomania: In individuals with a history of bipolar disorder, Vilazodone can trigger manic or mixed episodes. Disclose any past manic episodes or bipolar disorder treatments to your healthcare provider before starting this medication.

• Sexual Problems: Vilazodone may cause sexual side effects such as delayed ejaculation, low libido, or erectile dysfunction in males, and low libido or delayed orgasm in females. Discuss any pre-existing sexual issues with your provider, as they may influence your treatment plan.

• Contraindications: Avoid using Vilazodone if you are currently taking or have recently stopped taking a monoamine oxidase inhibitor (MAOI) within the last two weeks, as this can pose serious health risks.

Always consult with your healthcare provider regarding these risks and any other concerns you may have while taking antidepressant medications.

Common side effects:

• Diarrhea
• Nausea
• Headache
• Vomiting
• Dizziness
• Insomnia
• Dry mouth
• Sleepiness

Less common but important to monitor:

• Numbness
• Tremors
• Difficulty concentrating
• Confusion
• Memory issues
• Changes in sexual interest or ability

Serious side effects:

• Suicidal thoughts or behaviors
• Serotonin syndrome
• Serious bleeding
• Black stools
• Vomit resembling coffee grounds
• Seizures
• Changes in vision
• Eye pain or redness
• Allergic reactions

Certain medications may interact with this drug, potentially causing harmful effects. These include medications that can lead to increased bleeding or bruising, such as antiplatelet drugs like Clopidogrel, NSAIDs like Ibuprofen and Naproxen, and blood thinners like Dabigatran and Warfarin. Aspirin can also raise the risk of bleeding when combined with this medication. However, if your doctor has prescribed low-dose aspirin (81-162 milligrams daily) to help prevent heart attack or stroke, continue taking it unless advised otherwise by your doctor. Consult your doctor or pharmacist for more information.

Taking MAO inhibitors with this drug can lead to a serious, possibly life-threatening interaction. It is important to avoid MAO inhibitors, including isocarboxazid, linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine, during and for two weeks before and after treatment with this medication. Your doctor will guide you on when to start or stop these medications.

The risk of serotonin syndrome or toxicity is elevated if you are also taking drugs that increase serotonin levels. This includes certain illicit drugs like MDMA ("ecstasy"), herbal supplements like St. John's wort, and certain antidepressants, including SSRIs like Fluoxetine and paroxetine, and SNRIs like Duloxetine and Venlafaxine, as well as Tryptophan. The likelihood of serotonin syndrome/toxicity may increase when starting or increasing the dose of these drugs.

Additionally, this medication may affect some medical or laboratory tests, such as those used for diagnosing Parkinson's disease, potentially leading to incorrect results. Ensure that all medical personnel involved in your care are aware you are using this medication.