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Antidepressant medications, such as Vilazodone (Viibryd), are prescribed to treat conditions like depression and other mood disorders, providing important benefits, including the prevention of suicidal thoughts or attempts. However, there are essential safety and warning considerations to be aware of when using these medications:

• Suicidal Thoughts and Behavior: Antidepressants may increase the risk of suicidal thoughts or behaviors, particularly in individuals aged 24 or younger. Be vigilant for any worsening of depression or unusual changes in mood or behavior, especially during the initial treatment period or following a dosage change. Promptly report any concerning symptoms to your healthcare provider.

• Serotonin Syndrome: This rare but potentially life-threatening condition can occur if there is an excess of serotonin in the body, often when combined with other serotonergic drugs. Symptoms include a rapid heartbeat, sweating, muscle stiffness, fever, and confusion. Seek emergency medical attention if you experience any of these symptoms.

• Serious Bleeding: Vilazodone can increase the risk of bleeding, particularly if taken with other medications that also raise bleeding risks, such as NSAIDs, aspirin, and warfarin. Look out for signs such as persistent bruising, difficulty stopping bleeding, blood in urine, or dark stools, and inform your provider immediately.

• Low Sodium Levels (Hyponatremia): Be aware of symptoms like headaches, difficulty concentrating, memory issues, confusion, weakness, or unsteadiness, as these can indicate low sodium levels, which may lead to serious complications. Contact your provider if you have these symptoms.

• Eye Problems: Vilazodone may cause pupil dilation, potentially exacerbating conditions like angle-closure glaucoma. Report any eye pain, swelling, redness, or vision changes to your provider. An eye examination may be recommended if you have a history of eye conditions.

• Worsening of Mania or Hypomania: In individuals with a history of bipolar disorder, Vilazodone can trigger manic or mixed episodes. Disclose any past manic episodes or bipolar disorder treatments to your healthcare provider before starting this medication.

• Sexual Problems: Vilazodone may cause sexual side effects such as delayed ejaculation, low libido, or erectile dysfunction in males, and low libido or delayed orgasm in females. Discuss any pre-existing sexual issues with your provider, as they may influence your treatment plan.

• Contraindications: Avoid using Vilazodone if you are currently taking or have recently stopped taking a monoamine oxidase inhibitor (MAOI) within the last two weeks, as this can pose serious health risks.

Always consult with your healthcare provider regarding these risks and any other concerns you may have while taking antidepressant medications.

Common side effects:

• Diarrhea
• Nausea
• Headache
• Vomiting
• Dizziness
• Insomnia
• Dry mouth
• Sleepiness

Less common but important to monitor:

• Numbness
• Tremors
• Difficulty concentrating
• Confusion
• Memory issues
• Changes in sexual interest or ability

Serious side effects:

• Suicidal thoughts or behaviors
• Serotonin syndrome
• Serious bleeding
• Black stools
• Vomit resembling coffee grounds
• Seizures
• Changes in vision
• Eye pain or redness
• Allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
• Drugs that increase serotonin (e.g., MDMA, St. John's wort, SSRIs like fluoxetine/paroxetine, SNRIs like duloxetine/venlafaxine, tryptophan)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aspirin

Interactions with low risk that usually do not require a change in therapy:

• Antiplatelet drugs (e.g., clopidogrel)
• NSAIDs (e.g., ibuprofen, naproxen)
• Blood thinners (e.g., dabigatran, warfarin)