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This document outlines essential safety and warning information related to the use of the rivastigmine patch (Exelon). Patients and healthcare professionals should consider these points carefully to ensure safe and effective use. If you have any concerns, please consult your healthcare provider.

• Gastrointestinal Side Effects: Although the rivastigmine patch is applied to the skin, it may cause gastrointestinal issues such as nausea, vomiting, diarrhea, and reduced appetite. Severe or persistent symptoms could lead to dehydration and weight loss. These effects are more common at higher doses or if the dosage is increased too quickly.

• Skin Reactions: Application of the patch may result in skin irritation at the site. This typically resolves within 48 hours after removing the patch.

• Other Side Effects: The rivastigmine patch increases acetylcholine levels, potentially causing:

  • Movement disorders
  • Seizures
  • Gastrointestinal bleeding or peptic ulcers
  • Irregular heart rate or rhythm
  • Urinary issues
  • Respiratory problems

• Contraindications: Use of the rivastigmine patch (Exelon) is contraindicated if you have had a previous allergic reaction to the patch. Consult your healthcare provider if this applies to you.

It is crucial to adhere to these guidelines and report any adverse reactions to your healthcare provider promptly. In case of overdose, seek emergency medical attention immediately.

When taking this medication, some people may experience mild side effects such as nausea, vomiting, diarrhea, dizziness, tiredness, weakness, and skin irritation at the application site. These effects are generally minor and should not cause alarm. However, if they persist or worsen, it is advisable to consult a healthcare professional. Other possible side effects include stomach pain, loss of appetite, weight loss, headache, shakiness, depression, anxiety, trouble sleeping, and urinary tract infections.

In rare cases, more serious side effects can occur, and immediate medical attention is necessary. These include a slow or irregular heartbeat, black stools, vomit resembling coffee grounds, severe abdominal pain, seizures, and trouble urinating. Additionally, a severe allergic reaction is uncommon but requires urgent care if symptoms like a rash, itching, swelling, severe dizziness, or trouble breathing develop.

If you notice any severe side effects such as a rapid heartbeat, fainting, or a serious skin reaction including redness, swelling, or blisters, it is crucial to seek medical help right away. This information is intended to ensure awareness of potential side effects while reinforcing the importance of consulting a healthcare provider for any concerns.

When using rivastigmine, particularly in patch form known as Exelon, it is important to be aware of potential interactions with other medications. Rivastigmine can interact with drugs such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. Combining these can heighten the risk of stomach or intestinal bleeding. If your doctor has recommended low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue taking it unless advised otherwise by your healthcare provider.

Additionally, rivastigmine should not be used with bromopride, as this combination is generally not recommended. There are also medications like metoclopramide and a variety of beta-blockers (e.g., acebutolol, atenolol, metoprolol) that may require careful management if used together with rivastigmine, as your doctor might need to adjust dosages or the frequency of use.

Furthermore, drugs such as oxybutynin and tolterodine might increase the risk of certain side effects when used with rivastigmine, but they may still be necessary depending on your treatment plan. Always inform your doctor and pharmacist of all the medications, including over-the-counter drugs, vitamins, and supplements you are taking to ensure safe and effective use of rivastigmine.