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When taking this medication, you might experience drowsiness, dizziness, tiredness, nausea, vomiting, constipation, decreased appetite, diarrhea, or weakness. These are common side effects and often temporary. However, if they persist or worsen, it's important to consult with a healthcare professional.

Be alert for more serious side effects, such as difficulties with walking, balance, coordination, or vision (including blurred or double vision). You might also experience vertigo, trouble with reading, speaking, or writing, and signs of liver issues like persistent nausea, abdominal pain, yellowing of the skin or eyes, and dark urine. It is crucial to seek medical advice immediately if these occur.

In rare cases, very severe reactions can happen. These include a fast or irregular heartbeat, severe dizziness, or fainting. Additionally, some individuals using anticonvulsants may experience mood changes, depression, or suicidal thoughts. If you or those around you notice unusual shifts in mood or behavior, such as confusion or memory problems, contact a healthcare provider promptly.

Though extremely uncommon, serious allergic reactions can occur, characterized by fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or breathing difficulties. Immediate medical attention is necessary if these symptoms arise.

This summary includes possible side effects but is not exhaustive. If you experience other unexpected symptoms, reach out to a healthcare provider for guidance.

Cenobamate may speed up the breakdown of certain medications in your body, which can alter their effectiveness. Medications that could be affected include asunaprevir, elacestrant, lonafarnib, mavacamten, the combination of ombitasvir/paritaprevir/ritonavir, quizartinib, and revumenib, among others. Additionally, cenobamate may reduce the effectiveness of hormonal contraceptives like pills, patches, or rings, potentially leading to pregnancy. It's important to talk to your doctor or pharmacist about using a reliable backup contraceptive method while on cenobamate. Notify your doctor if you experience any unusual spotting or breakthrough bleeding, as these may indicate that your birth control isn't working properly.

Inform your doctor or pharmacist if you use other substances that can cause drowsiness, such as opioid pain relievers or cough suppressants (including codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (like Alprazolam, Lorazepam, Zolpidem), muscle relaxants (such as Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine). Be sure to check the labels on all your medications, including allergy and cold remedies, as they might contain ingredients that cause drowsiness. Consult your pharmacist about the safe use of these products.