Allopurinol

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allopurinol

Allopurinol, also known by the brand name Zyloprim, is a medication primarily used to manage gout and prevent certain types of kidney stones in adults. It is effective in reducing uric acid levels in the body by inhibiting the enzyme xanthine oxidase, which is responsible for uric acid production. This action helps prevent gout attacks and the formation of recurrent calcium oxalate kidney stones. Additionally, Allopurinol is used to prevent tumor lysis syndrome, a condition characterized by elevated uric acid levels due to the breakdown of cancer cells during chemotherapy. This medication is typically taken orally and is available as a cost-effective generic option. While side effects like diarrhea and nausea are possible, they are generally mild. Always consult with a healthcare professional before starting Allopurinol to ensure it is safe and appropriate for your specific health needs.
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100MG, Allopurinol (30 Tablets)

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$18.63

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Zyloprim dosage forms

The average cost for 30 Tablets of Zyloprim (allopurinol) at 100MG is $2 with a free coupon. This is 9.13% off the average retail price of $21.9
DosageQuantityPrice fromPer unit
100MG30 Tablets$2$0.07
300MG30 Tablets$4.73$0.16

Zyloprim Warnings

Below is a professional and clear summary of critical safety information and warnings associated with the use of allopurinol (Zyloprim). Please read this carefully and consult your healthcare provider with any questions or concerns.

  • Severe Skin Reactions: Rare but potentially life-threatening skin reactions may occur, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and DRESS syndrome. The risk is heightened during the initial months of treatment, especially if you have the HLA-B 58:01 gene, are of African or Asian descent, have kidney issues, or are taking thiazide diuretics, bendamustine, ampicillin, or amoxicillin.

  • Increased Gout Attacks: During the first few months of treatment, you may experience more frequent gout flares. This happens as the medication lowers uric acid levels rapidly, potentially causing joint irritation and inflammation.

  • Kidney Stones and Injury: There is a possibility of developing kidney stones, which could lead to kidney injury. This risk is higher in individuals with a history of kidney problems or stones, as well as those who are dehydrated.

  • Liver Damage: Allopurinol (Zyloprim) can cause liver damage, which is often reversible upon discontinuation of the medication. Though usually mild, it can be severe in rare cases. Regular monitoring of liver enzymes is advised, particularly if you have pre-existing liver conditions. Be alert for symptoms such as appetite loss, weight loss, itching, or yellowing of the skin or eyes, and contact your healthcare provider if these occur.

  • Low Blood Cell Counts: Although rare, this medication can lead to decreased levels of red blood cells, white blood cells, or platelets, increasing the risk of anemia, infections, and easy bleeding or bruising. This condition can develop from one month to several years after beginning treatment.

  • Sleepiness and Dizziness: Allopurinol (Zyloprim) may cause dizziness or sleepiness, affecting cognitive functions and reaction times. The risk increases if you are also using medications that induce drowsiness, such as benzodiazepines, muscle relaxants, or sleep aids, or if you are taking high doses of allopurinol.

Please ensure you adhere to these guidelines and promptly communicate with your healthcare provider if you experience any adverse effects or have concerns regarding your treatment.

Zyloprim Side Effects

When taking this medication, you may experience common side effects that are generally mild and temporary. These include stomach upset, nausea, diarrhea, drowsiness, and elevated liver enzymes. If these symptoms persist or worsen, it's advisable to consult with your healthcare provider for guidance. Other side effects that may occur include rashes, headaches, and changes in taste, as well as joint or muscle pain. It's important to monitor these symptoms and seek advice if necessary.

Serious side effects, although rare, demand immediate medical attention. These include severe skin reactions such as painful blisters, skin peeling, or hives, which can be life-threatening. Certain ethnic groups may have a higher risk of these severe skin reactions. Additionally, watch for signs of severe allergic reactions like facial swelling, difficulty breathing, or anaphylaxis, which require urgent care. Liver issues may also arise, indicated by symptoms such as persistent nausea, vomiting, abdominal pain, or yellowing of the skin and eyes. Low blood cell counts may present with fever, unusual bruising, or blood in urine or stool, necessitating prompt medical evaluation.

Always be vigilant for any unusual symptoms and seek immediate medical assistance for severe reactions to ensure your safety. If you notice any other effects not listed here, contacting your healthcare provider is recommended.

Zyloprim Interactions

When taking Allopurinol (Zyloprim), it is important to inform your doctor and pharmacist about all the medications and supplements you are using, including prescription, over-the-counter, vitamins, and herbal products. This medication can interact with several other drugs, potentially affecting their efficacy or increasing side effects.

Some interactions with Allopurinol include:

  1. Not Recommended:

    • Didanosine: Using Allopurinol with Didanosine is not advised due to potential severe interactions. Your healthcare provider may choose an alternative treatment or adjust your existing medications.
  2. Usually Not Recommended but May Be Necessary:

    • Blood Thinners (e.g., Warfarin, Acenocoumarol, Phenprocoumon): These may require dose adjustments if used together with Allopurinol.
    • Capecitabine, Azathioprine, Fluorouracil, Mercaptopurine, Pegloticase: Caution is advised as these combinations might necessitate dosage changes or increased monitoring.
    • ACE Inhibitors (e.g., Captopril, Enalapril, Enalaprilat): May require special attention if prescribed together with Allopurinol.
    • Tegafur: Similar precautions as above may be necessary.
  3. Increased Risk of Side Effects:

    • Aluminum Hydroxide, Cyclosporine, Vidarabine: These combinations may enhance side effects, but may also be necessary, requiring careful dose management and monitoring.

Always consult your doctor before making any changes to your medication regimen to ensure safe and effective treatment.

Zyloprim FAQs
What is the drug Zyloprim used for?

Zyloprim is used to treat gout and certain types of kidney stones. It is also used to decrease levels of uric acid in people who are receiving cancer treatment.

The most common side effect of allopurinol is a skin rash. If a rash develops, it is important to contact a healthcare provider, as it may indicate a more serious reaction.

When taking allopurinol, it is important to avoid alcohol, as it can increase uric acid levels and reduce the effectiveness of the medication. Additionally, patients should avoid high-purine foods, such as red meat, organ meats, and certain seafood, as these can also elevate uric acid levels. It is also advisable to avoid dehydration by maintaining adequate fluid intake. Patients should consult their healthcare provider for a comprehensive list of specific foods and substances to avoid.

Zyloprim (allopurinol) carries several warnings. It may cause severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be life-threatening. Patients should be advised to stop taking the medication and seek medical attention if they experience any signs of a rash or skin changes. Additionally, Zyloprim can cause liver and kidney function impairment, so regular monitoring of liver and kidney function tests is recommended. It is also important to ensure adequate hydration to prevent kidney stones. Patients with a history of hypersensitivity to allopurinol should not take this medication.

Yes, it is generally recommended to drink plenty of water when taking allopurinol. Staying well-hydrated helps to prevent the formation of kidney stones and supports the elimination of uric acid from the body.