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This document provides crucial safety information about Donepezil (Aricept). It outlines potential risks, necessary precautions, and guidance on its use. Consult your healthcare provider if you have any questions or experience any adverse effects.

• Slowed Heartbeat: Donepezil may reduce your heart rate, which can occasionally lead to fainting. To minimize this risk, consider taking the medication at bedtime. It's important to inform your healthcare provider if you experience falls or dizziness, as a dosage adjustment might be necessary.

• Nausea and Vomiting: Common side effects such as nausea, vomiting, and diarrhea often occur when starting Donepezil or increasing the dosage. These effects usually subside after a few weeks. If these side effects are severe and interfere with your daily medication routine, contact your healthcare provider, especially if you weigh less than 55 kg (121 lbs) or are taking higher doses.

• Stomach Ulcers and Bleeds: Donepezil can increase stomach acid production, raising the risk of ulcers and bleeding, particularly at the maximum dose of 23 mg. The use of NSAIDs can further elevate this risk. It's advisable to avoid combining these drugs with Donepezil. Contact your healthcare provider if you experience increased stomach discomfort, heartburn, or indigestion.

• Weight Loss: Weight loss is a potential side effect, reported by approximately 5% of individuals on a 23 mg dose and 3% on a 10 mg dose during clinical trials. More significant weight reduction was noted in those on the higher dose. Notify your healthcare provider if this is a concern for you.

There are no known contraindications for Donepezil. Always consult your healthcare provider for personalized advice and to address any specific health conditions.

When taking this medication, some individuals may experience common side effects, which are generally mild but should be discussed with a healthcare provider if they persist or worsen. These include nausea (11%), diarrhea (10%), headache (10%), trouble sleeping (insomnia, 9%), pain (9%), dizziness (8%), muscle cramps (6%), tiredness (5%), vomiting (5%), and loss of appetite (4%). These are typical reactions and often resolve on their own.

In addition to the common side effects, there are other potential reactions that have been reported. While less common, it's important to be aware of them. These include bruising, sleepiness, fainting, depression, abnormal dreams, weight loss, arthritis (joint pain or swelling), and increased urination. If you experience any of these, especially if they are severe or concerning, it is recommended to seek medical advice.

Currently, there are no serious side effects listed for this medication, suggesting a favorable safety profile. However, always remain vigilant and report any unusual or worrying symptoms to your healthcare provider promptly to ensure safe and effective use of the medication.