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Haloperidol Safety Information and Warnings

When considering the use of haloperidol, it is crucial to understand the associated risks and precautions. This medication is associated with several serious side effects, particularly for certain populations. Below are key safety warnings and instructions to discuss with your healthcare provider.

• Increased Mortality in Older Adults with Dementia-Related Psychosis: Individuals aged 65 and older with dementia-related psychosis may face a higher risk of death when using haloperidol. This medication is not approved for managing dementia-related behavioral issues. Discuss alternative treatments with your healthcare provider if you or your loved one has dementia.

• QT Prolongation and Heart Risks: Haloperidol can lead to a rare but serious condition known as QT prolongation, affecting heart rhythm. This risk is heightened in those with low potassium or magnesium levels, existing heart conditions, congenital QT prolongation, or those taking other medications that affect heart rhythm. If you experience symptoms like chest pain, trouble breathing, or lightheadedness, seek emergency medical attention immediately.

• Uncontrolled Body Movements: Prolonged use or high doses of haloperidol can cause involuntary movements, especially in individuals with Parkinson's disease or some forms of dementia. These movements may become permanent, so contact your healthcare provider if you notice any such symptoms.

• Neuroleptic Malignant Syndrome (NMS): NMS is a rare but potentially fatal condition that may occur with antipsychotic use, including haloperidol. Symptoms include high fever, muscle rigidity, confusion, and irregular heartbeat. Immediate medical intervention is required if these symptoms appear.

• Risk of Falls: Haloperidol can cause drowsiness, lower blood pressure, and balance issues, increasing the risk of falls. Rise slowly from seated or lying positions and consult your provider if you are concerned about falls.

• Lung Infections: Use of haloperidol has been linked to cases of bronchopneumonia, particularly in older adults, smokers, or those with respiratory issues. Seek medical help if you experience symptoms like fever, cough, or breathing difficulties.

• Low White Blood Cell Counts: Haloperidol may reduce white blood cell counts, elevating the risk of infection. Regular blood tests are recommended during initial treatment. Contact your provider if you develop infection symptoms such as fever or persistent cough.

• Pregnancy Risks: Haloperidol should be used during pregnancy only if the benefits justify potential risks to the unborn child. Inform your healthcare provider if you are pregnant or planning to become pregnant while on this medication, as newborns may experience side effects or withdrawal symptoms.

• Contraindications: Do not use haloperidol if you have severe central nervous system depression, are in a coma, or have Parkinson's disease. Consult your healthcare provider for guidance based on your medical history.

Always discuss the full range of risks and benefits of haloperidol with your healthcare provider to ensure it is the appropriate treatment for your condition.

Common side effects:

• Dizziness
• Lightheadedness
• Drowsiness
• Headaches
• Difficulty urinating

• Sleep disturbances

  Less common but important to monitor:

• Muscle spasms
• Tremors
• Restlessness
• Mask-like facial expression
• Mood changes (anxiety and depression)
• Severe nausea or vomiting
• Stomach pain
• Yellowing of the skin or eyes
• Seizures
• Signs of infection (persistent sore throat or fever)
• Unwanted breast milk production
• Menstrual irregularities

• Decreased sexual ability

  Serious side effects:

• Tardive dyskinesia
• Neuroleptic malignant syndrome (NMS)
• Painful or prolonged erection lasting over four hours
• Allergic reactions (rash, itching, or trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Bromopride
• Cisapride
• Dronedarone
• Fluconazole
• Levomethadyl
• Mesoridazine
• Metoclopramide
• Nelfinavir
• Pimozide
• Piperaquine
• Posaconazole
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abametapir
• Acecainide
• Ajmaline
• Amiodarone
• Amitriptyline
• Apomorphine
• Aripiprazole
• Azithromycin
• Bedaquiline
• Buprenorphine
• Bupropion
• Cabergoline
• Cannabidiol
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clozapine
• Codeine
• Erythromycin
• Escitalopram
• Fentanyl
• Fluoxetine
• Hydrocodone
• Lithium
• Methadone
• Moxifloxacin
• Ondansetron
• Paroxetine
• Pergolide
• Quetiapine
• Quinidine
• Sotalol
• Tramadol
• Voriconazole

Interactions with low risk that usually do not require a change in therapy:

• Benztropine
• Buspirone
• Carbamazepine
• Fluvoxamine
• Methyldopa
• Olanzapine