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This drug is associated with several important safety warnings and precautions. It's crucial to understand these potential risks and consult with your healthcare provider if you have any questions or concerns:

• Pregnancy Warning: Usage of this medication during pregnancy can cause serious and potentially fatal harm to an unborn baby. It is essential to prevent pregnancy while on this medication. If you become pregnant or are planning to become pregnant, inform your doctor immediately to discuss safer alternatives for managing your blood pressure.

• Low Blood Pressure: This medication may lead to a significant drop in blood pressure, causing dizziness, fatigue, or lightheadedness. This effect is more likely if you're dehydrated due to diarrhea or vomiting, or if you have heart failure. Ensure you maintain proper hydration and inform your healthcare team if you experience any symptoms of low blood pressure. Seek immediate medical attention if you fall and sustain a head injury.

• Kidney Problems: While this medication can generally protect the kidneys, it may also cause kidney injury in certain cases, such as severe heart failure or renal artery stenosis. Notify your healthcare provider if you experience any issues with urination.

• Electrolyte and Metabolic Changes: The medication can affect electrolyte balance, blood sugar, and cholesterol levels. Monitor these regularly, especially if taking other medications that affect these parameters.

• Allergic Reactions: There is a risk of allergic reactions, particularly if you have a history of allergies, asthma, or sulfa allergies. Report any symptoms like rash, itching, hives, breathing difficulties, or facial swelling to your doctor immediately.

• Vision Issues: Rarely, the medication may cause changes in vision or eye pain. Report any vision changes to your healthcare provider promptly.

• Lupus: This medication may induce or exacerbate lupus symptoms. Consult your doctor if you notice symptoms such as extreme fatigue, joint pain, or a facial rash.

Contraindications:

• Do not use this medication if you are unable to urinate.
• Avoid concurrent use with aliskiren (Tekturna) if you have diabetes.
• Do not take if you are allergic to candesartan, hydrochlorothiazide, or sulfa medications.

Always discuss any health concerns or pre-existing conditions with your healthcare provider before starting this medication.

Common side effects:

• Dizziness
• Upper respiratory tract infections
• Back pain
• Flu-like symptoms

Less common but important to monitor:

• Cough
• Itching
• Rash
• Muscle spasms
• Blurry vision
• Stomach cramps
• Dehydration
• Electrolyte imbalance
• Unusually dry mouth or thirst
• Irregular heartbeat
• Confusion

Serious side effects:

• Dangerously low blood pressure
• Kidney problems
• Abnormal electrolyte levels
• Severe dizziness
• Reduced urination
• Unexplained weight gain
• Nausea
• Muscle weakness
• Vision problems
• Severe allergic reactions
• Breathing difficulties
• Swelling of the face, lips, or throat

Interactions with high risk of serious adverse effects and should be avoided:

• Dofetilide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren
• Lithium
• Drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including Benazepril/Lisinopril)
• Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen/Naproxen