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When using nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, it is important to be aware of certain risks and precautions. Please review the following key points for safe use:

• Risk of Heart Attack or Stroke: Ibuprofen may occasionally increase the risk of a heart attack or stroke. This risk can occur at any time during use but is heightened with prolonged usage. Older adults and individuals with heart disease or risk factors such as smoking, family history of heart disease, high blood pressure, or diabetes are more susceptible. Avoid taking this medication immediately before or after heart bypass surgery (CABG).

• Gastrointestinal Bleeding: There is a rare possibility of serious, potentially fatal bleeding in the stomach or intestines, which can occur without warning. This risk is higher for older adults.

• Urgent Medical Attention: Discontinue ibuprofen and seek immediate medical attention if you experience any of the following uncommon but severe symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

• Consultation with Healthcare Professionals: Discuss with your doctor or pharmacist to understand the benefits and risks associated with ibuprofen use.

By adhering to these guidelines, you can help ensure safe and effective use of ibuprofen.

You might experience mild side effects like an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are usually not serious and often improve as your body adjusts to the medication. However, if they persist or worsen, it's important to consult your healthcare provider.

This medication can cause an increase in blood pressure, so it's advisable to monitor your blood pressure regularly and inform your healthcare provider if you notice elevated readings. While most people do not experience severe side effects, be vigilant for symptoms such as easy bruising or bleeding, changes in hearing (like ringing in the ears), mood alterations, an unexplained stiff neck, possible kidney issues (e.g., changes in urine output), vision changes, or signs of heart failure (such as swelling in the ankles or feet, unusual tiredness, or sudden weight gain). These require immediate medical attention.

In rare cases, this medication may lead to severe liver disease, which can be life-threatening. Seek urgent medical care if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach pain, or yellowing of the eyes or skin. Allergic reactions are uncommon but can be serious. Get emergency help if you develop symptoms like fever, swollen lymph nodes, rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you notice any other unusual effects, reach out to your healthcare provider.

Certain medications can interact with this drug, including Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Valsartan and Losartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics like Furosemide. Taking this medication with others that also increase bleeding risk can raise the likelihood of bleeding. These include anti-platelet drugs such as Clopidogrel and blood thinners like Dabigatran, Enoxaparin, and Warfarin.

It's important to read labels on all medications, including over-the-counter ones, carefully. Many contain pain relievers or fever reducers like Aspirin and NSAIDs (e.g., Celecoxib, Ketorolac, Naproxen) that are similar to Ibuprofen and could enhance side effects if used together. However, if your doctor has advised taking low-dose aspirin (81-162 mg daily) to prevent heart attack or stroke, continue doing so unless told otherwise. Regular ibuprofen use might reduce aspirin's effectiveness for heart protection. Discuss alternatives like Acetaminophen for pain or fever with your doctor. If ibuprofen is necessary, consult your doctor about using immediate-release aspirin instead of enteric-coated forms. Take ibuprofen at least 8 hours before or 2 hours after your aspirin dose. Do not alter your aspirin dosage or how you take any medications without your doctor’s guidance.