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Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), carries several important safety warnings that should be carefully considered before use. These warnings include potential risks and necessary precautions to ensure safe use, particularly for individuals with specific health conditions.

• Heart Risks: Ibuprofen may increase the risk of heart attack or stroke, especially when taken for prolonged periods. This is particularly relevant for older adults and those with existing heart conditions or risk factors such as high blood pressure, diabetes, or smoking habits. It is advised not to use ibuprofen immediately before or after heart bypass surgery (CABG). If you experience symptoms like chest pain, shortness of breath, or weakness on one side of the body, seek emergency medical assistance.

• Stomach and Intestinal Bleeding: There is a risk of serious, potentially fatal bleeding in the stomach or intestines, which can occur without warning. The risk is higher in older adults, those with a history of ulcers or bleeding, and individuals taking blood thinners or consuming alcohol. It's crucial to contact a healthcare provider if you experience symptoms such as persistent stomach pain, black or tarry stools, or vomit resembling coffee grounds.

• High Blood Pressure and Heart Failure: Ibuprofen can cause fluid retention, leading to increased blood pressure and the risk of heart failure. Individuals with a history of heart issues or those on blood pressure medications should consult their healthcare provider before using ibuprofen.

• Kidney Damage: Ibuprofen may impair kidney function, particularly in older adults or those with pre-existing kidney issues or diabetes. Regular monitoring of kidney health may be necessary during long-term treatment. Report signs of kidney problems, such as changes in urination, fatigue, or muscle cramps, to your healthcare provider promptly.

• Liver Problems: Though rare, ibuprofen can lead to severe liver damage. Immediate medical attention is necessary if symptoms like stomach swelling, yellowing of the skin or eyes, or dark urine occur.

• Severe Allergic Reactions: Ibuprofen can cause severe allergic reactions, including anaphylaxis. Avoid use if you have a known allergy to aspirin or other NSAIDs, and seek medical help if symptoms such as hives, facial swelling, or difficulty breathing arise.

• Pregnancy Considerations: Ibuprofen can be harmful to an unborn baby, especially if taken after the 20th week of pregnancy. Discuss the risks and alternatives with your healthcare provider if you are pregnant.

• Phenylketonuria (PKU): The chewable form of ibuprofen contains phenylalanine, posing a risk for individuals with PKU. Consult a healthcare provider for suitable alternatives.

Contraindications: Ibuprofen should not be used by individuals with a history of asthma or allergic reactions to aspirin or other NSAIDs, or by those undergoing coronary artery bypass graft surgery. Always discuss your medical history and current medications with your healthcare provider to evaluate the safety of ibuprofen for your use.

When taking this medication, you may experience some common side effects such as an upset stomach, nausea, stomach pain, vomiting, headache, dizziness, diarrhea, constipation, rash, or drowsiness. These effects are usually mild, but if they persist or worsen, it's advisable to consult your healthcare provider.

In some cases, this medication may increase blood pressure, so it's important to monitor your levels regularly. Rare, but more serious side effects that require immediate medical attention include easy bruising or bleeding, changes in hearing like ringing in the ears, mental or mood changes, unexplained stiff neck, vision changes, or signs of kidney problems such as altered urine output. Symptoms of heart failure, such as swelling in the ankles or feet, unusual tiredness, or sudden weight gain, also warrant urgent care.

Very rarely, this medication can cause severe liver damage. If you notice persistent nausea or vomiting, loss of appetite, dark urine, stomach pain, or yellowing of the eyes or skin, seek medical help right away. Additionally, though rare, allergic reactions may occur, presenting symptoms such as fever, swollen lymph nodes, rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing. Immediate medical attention is crucial if any signs of an allergic reaction appear.

If you notice any other side effects not mentioned here, it's important to contact your healthcare provider for advice. While many people experience no or minor side effects, staying informed and vigilant ensures your safety while using this medication.

When taking Ibuprofen, it's important to be aware of potential interactions with other medications. Some drugs that may interact include Aliskiren, ACE inhibitors like Captopril and Lisinopril, and angiotensin II receptor blockers such as Valsartan and Losartan. Ibuprofen can also interact with Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics such as Furosemide.

Additionally, ibuprofen may elevate the risk of bleeding if taken with other medications that also increase bleeding risk. These include anti-platelet drugs like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, and Warfarin.

It is crucial to check all medication labels, including over-the-counter ones, as many contain pain relievers or fever reducers like Aspirin or NSAIDs (e.g., Celecoxib, Ketorolac, Naproxen) that are similar to ibuprofen and could heighten side effects if taken together. However, if you are on a doctor-prescribed regimen of low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention, continue with it unless advised otherwise by your doctor. Daily use of ibuprofen might reduce aspirin's effectiveness in preventing heart attack or stroke, so consult your doctor about possibly using Acetaminophen for pain or fever instead. If ibuprofen use is necessary, discuss with your doctor the option of taking immediate-release aspirin (not enteric-coated) and schedule ibuprofen intake at least 8 hours before or 2 hours after your aspirin dose. Never adjust your aspirin or other medication doses without professional guidance.

Lastly, always inform your healthcare provider about any other medicines or supplements you are taking, as this information is vital to prevent harmful interactions.