
Darunavir Coupons & Discount Card - Compare Prices Near You
generic Prezista
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600MG, Darunavir (30 Tablets)
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CVS
$92.16
COUPON PRICE
Rite Aid
$45.75
COUPON PRICE
Walgreens
$268.43
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Albertsons
$292.36
COUPON PRICEDarunavir savings card
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CVS
$92.16
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PCN
GRP
019876
LH344F2D75
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Darunavir dosage forms
Dosage | Quantity | Price from | Per unit |
---|---|---|---|
600MG | 30 Tablets | $47.55 | $1.58 |
800MG | 30 Tablets | $72.33 | $2.41 |
Darunavir Warnings
This medication comes with several important warnings that are crucial for your safety. It is essential to carefully review these and discuss any concerns with your healthcare provider.
Liver Issues: There is a risk of severe liver problems, especially during the initial months of using Prezista (darunavir). It is vital to undergo blood tests before and during treatment to monitor liver health. Contact your healthcare provider immediately if you notice symptoms like drowsiness, nausea, loss of appetite, pale stools, upper right abdominal pain, jaundice, or dark urine. This risk is heightened if you have hepatitis B or C or a history of liver issues.
Severe Skin and Allergic Reactions: If you have a sulfa allergy or are taking Isentress (raltegravir) with Prezista (darunavir) and ritonavir (Norvir), you may experience skin rashes. While mild to moderate rashes typically resolve themselves, report them to your provider. For severe rashes or if symptoms worsen, such as fever, discomfort, muscle or joint pain, mouth sores, blisters, or facial swelling, discontinue use and seek medical attention immediately.
Body Fat Changes: Some individuals have noticed changes in body fat distribution when taking HIV medications like Prezista (darunavir). This may involve fat accumulation in certain areas or fat loss from the limbs and face. The cause and long-term health effects are unclear. Report any such changes to your healthcare provider.
Overactive Immune System: Combining Prezista (darunavir) with other HIV therapies can lead to immune reconstitution syndrome, where the immune system becomes overly active. This may manifest as new symptoms like fever, pain, hair loss, bulging eyes, or increased sweating. Notify your provider if these occur, as it can happen early in treatment or much later.
Bleeding Concerns: People with hemophilia or other bleeding disorders may experience increased bleeding when using protease inhibitors like Prezista (darunavir). If you notice joint pain and swelling or skin bruising, contact your provider immediately as these might indicate blood accumulation.
Drug Interactions: Certain medications can affect how Prezista (darunavir) is eliminated from your body, altering its effectiveness and side effects. Discuss all medications you are taking with your healthcare provider to prevent potential interactions.
Contraindications: Avoid using this medication with certain drugs that can significantly increase the risk of serious side effects, such as alfuzosin, dronedarone, lovastatin, simvastatin, and triazolam. If you are taking any of these, consult with your healthcare provider before starting Prezista (darunavir).
Darunavir Side Effects
Common side effects:
- Diarrhea
- Rash
- Nausea
- Headache
- Stomach pain
- Vomiting
Less common but important to monitor:
- Feeling weak
- Indigestion
- Swollen belly
- Weight loss
- Tiredness
- Excessive gas
- Muscle pain
- Irregular dreams
- Itching
Serious side effects:
- Serious allergic reactions (facial swelling, hives, itchy skin, blistering or peeling skin, breathing difficulties)
- Serious liver problems (persistent nausea, vomiting, loss of appetite, right-side stomach pain, yellowing of the skin or eyes, dark urine, light-colored stools)
- Spikes in blood sugar levels (increased thirst or urination)
Darunavir Interactions
Interactions with high risk of serious adverse effects and should be avoided:
- Alfuzosin
- Astemizole
- Carbamazepine
- Cisapride
- Colchicine
- Dihydroergotamine
- Domperidone
- Dronedarone
- Ergonovine
- Ergotamine
- Grazoprevir
- Lovastatin
- Lurasidone
- Maraviroc
- Methylergonovine
- Midazolam
- Phenobarbital
- Phenytoin
- Pimozide
- Ranolazine
- Rifampin
- Sildenafil
- Simvastatin
- St John's Wort
- Terfenadine
- Triazolam
Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:
- Alfentanil
- Alprazolam
- Amiodarone
- Atorvastatin
- Avanafil
- Bosentan
- Buprenorphine
- Conivaptan
- Dabigatran
- Dasabuvir
- Erythromycin
- Ethinyl Estradiol
- Fentanyl
- Haloperidol
- Hydrocodone
- Imipramine
- Lopinavir
- Methadone
- Modafinil
- Naloxegol
- Nelfinavir
- Oxycodone
- Paritaprevir
- Propranolol
- Quetiapine
- Rifabutin
- Rifapentine
- Rivaroxaban
- Saquinavir
- Secobarbital
- Tacrolimus
- Tramadol
- Trazodone
- Venlafaxine
- Vinblastine
- Vincristine
Interactions with low risk that usually do not require a change in therapy:
- Clarithromycin
- Cobicistat
- Digoxin
- Indinavir
- Ketoconazole
- Tenofovir Disoproxil Fumarate
Is darunavir a sulfa drug?
Yes, darunavir is a sulfa drug. It contains a sulfonamide moiety, so individuals with a known sulfa allergy should use it with caution and under medical supervision.
How much does darunavir cost?
The cost of darunavir can vary depending on factors such as the pharmacy, location, insurance coverage, and dosage. Without insurance, the price can be quite high, often several hundred dollars for a month's supply. It is advisable to check with local pharmacies or online resources for the most accurate and current pricing. Additionally, patients may explore patient assistance programs or generic options to help reduce costs.
Why is ritonavir combined with darunavir?
Ritonavir is combined with darunavir to enhance the effectiveness of darunavir. Ritonavir acts as a pharmacokinetic booster by inhibiting the enzyme CYP3A4, which metabolizes darunavir. This inhibition increases the levels of darunavir in the blood, allowing for more effective suppression of the HIV virus with lower doses of darunavir.
Does darunavir cause weight gain?
Darunavir is not commonly associated with weight gain. However, individual responses to medications can vary, and some patients may experience changes in weight. If there are concerns about weight changes while taking darunavir, it is advisable to consult a healthcare provider for personalized advice and management.
What is darunavir and ritonavir used for?
Darunavir and ritonavir are used together as part of antiretroviral therapy to treat human immunodeficiency virus (HIV) infection. Darunavir is a protease inhibitor, and ritonavir is used to boost its effectiveness by increasing its levels in the blood. This combination helps to reduce the amount of HIV in the body, improving immune function and reducing the risk of developing acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.