Xyzal vs Zyrtec - Compare Antihistamines Allergy Prescriptions

By: Dr. Caitlin Colvard | MD

SaveHealth, the prescription savings card website compares Xyzal vs Zyrtec. Xyzal (levocetirizine) and Zyrtec (cetirizine) are antihistamines widely used to treat allergy symptoms like sneezing, runny nose, and itchy eyes. Both medications block histamine, a chemical responsible for allergic reactions. While Xyzal contains only the active component of Zyrtec (levocetirizine), Zyrtec includes both active and inactive forms. Available over-the-counter and by prescription, these 24-hour relief options are popular for managing seasonal and year-round allergies. 

Xyzal vs Zyrtec - Mechanism of Action 

Both medications reduce allergy symptoms by preventing histamine from binding to receptors. Xyzal’s purified form may lead to fewer side effects in some users. 

Zyrtec vs Xyzal - Effectiveness Comparison 

Onset of Action: Both start working within 1 hour, but Xyzal may act faster in some cases. Duration: Xyzal’s effects last up to 28 hours, while Zyrtec provides 24-hour relief. 

Clinical Studies: 

Xyzal showed superior symptom improvement in adults compared to Allegra and Claritin. Zyrtec may be more effective for children with perennial allergic rhinitis. 

Symptom Relief: Both treat sneezing, itching, and hives, but Zyrtec-D includes a decongestant for nasal congestion. 

Xyzal vs Zyrtec - Dosage and Forms

Zyrtec offers more flexibility with chewable tablets and orally disintegrating forms.

Zytrec vs Xyzal - Side Effects and Safety 

Common Side Effects: 

Xyzal: Drowsiness (5-6%), dry mouth (2%), fatigue (6%). 

Zyrtec: Drowsiness (14%), dry mouth (2-5%), headache (10-14%), fatigue (3-10%). 

FDA Warning: Severe itching (pruritus) may occur within days of stopping long-term use of either drug. Symptoms often resolve upon restarting the medication. 

Contraindications: Avoid alcohol and CNS depressants. Use caution in kidney/liver disease or urinary retention. 

Zyrtec vs Xyzal - Pros and Cons 

Xyzal Pros: 

• Less incidence of side effects including: drowsiness, fatigue and headache

• Faster onset and longer duration in studies. 

• Suitable for children as young as 2. 

Xyzal Cons: 

• Limited dosage forms. 

Zyrtec Pros: 

• Multiple forms (chewables, liquids, ODTs). 

• Zyrtec-D combats nasal congestion. 

Zyrtec Cons: 

• Higher reported drowsiness. 

Alternatives

Nasal Sprays: Allermi combines antihistamines, decongestants, and anti-inflammatories for rapid relief (10-minute onset). 

Other Antihistamines: Allegra (fexofenadine) or Claritin (loratadine) for non-drowsy options.

Combination Therapies: Discuss with a healthcare provider for personalized plans, especially for chronic symptoms. 

Xyzal vs Zyrtec

Xyzal and Zyrtec are equally effective but differ in side effect profiles and dosage flexibility. Xyzal may be preferable for those sensitive to drowsiness; Zyrtec offers more forms. Severe itching after discontinuation is rare but possible. Consult a doctor if symptoms arise. Consider alternatives like nasal sprays or combination therapies for comprehensive allergy management.

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This article is for educational purposes only and does not substitute for professional medical advice. Always consult your healthcare provider before starting or changing medication.