10 Popular Statin Medications - Comparison, Side Effects & How They Work

By: Noah W Chung | PharmD

Statins are among the most commonly prescribed medications for reducing high cholesterol and lowering the risk of heart attack and stroke. People searching for popular statin medications are often trying to understand the differences between the drugs, how they work, and which one might be the best fit for their health needs. They may also be curious about side effects, alternatives, and long-term benefits. Cost can play a role in choosing a statin, and many patients turn to discount prescription coupon websites like SaveHealth.com to compare pharmacy prices and reduce the out-of-pocket cost of their prescriptions.

This guide breaks down ten of the most widely used statins, how they compare, and what to consider when discussing options with a healthcare provider.

How Statins Work

Statins reduce cholesterol by blocking an enzyme in the liver called HMG CoA reductase. This mechanism helps lower LDL cholesterol, often referred to as bad cholesterol, and can also modestly increase HDL, often referred to as good cholesterol. Statins can also help lower triglyceride formation, often referred to as fatty cholesterol, by reducing the fat in the blood. Lastly, statins slow the growth of fatty plaque formation, thus stabilizing the arteries which help to prevent heart attacks and strokes. Due to their dynamic effects on the body, statins are the gold standard for better cholesterol.

Core benefits of statins

• Lower LDL cholesterol

• Reduce triglycerides

• Increase HDL cholesterol

• Lower the risk of plaque buildup in the arteries

• Reduce the risk of heart attack and stroke

Because statins vary in strength and cost, it is common for patients to compare prices online. SaveHealth.com allows users to view pharmacy price differences so they can find more affordable options.

Top 10 Popular Statin Medications

Below is a list of the most frequently prescribed statins, including both brand name and generic options.

1. Atorvastatin: Atorvastatin, the generic for Lipitor, is one of the most widely prescribed cholesterol medications. It is known for its potency and strong LDL lowering ability.

2. Rosuvastatin: Rosuvastatin, the generic version of Crestor, is another high intensity statin. It may be more effective for people needing substantial LDL reduction.

3. Simvastatin: Simvastatin, the generic for Zocor, is widely used due to its affordability and long history. It is usually prescribed for moderate cholesterol lowering.

4. Pravastatin: Pravastatin, the generic for Pravachol, is often chosen for people who are sensitive to stronger statins. It has fewer drug interactions and less muscle-related side effects making it a good option for beginners.

5. Lovastatin: Lovastatin, the generic for Mevacor, is one of the earliest statins and remains popular today. It is often taken with food to improve absorption.

6. Pitavastatin: Pitavastatin, the generic for Livalo, is known for having fewer drug interactions and may be suitable for people who cannot tolerate other statins.

7. Fluvastatin: Fluvastatin, the generic for Lescol, is considered one of the milder statins and is another good option for those with muscle related side effects.

8. Ezetimibe and Simvastatin Combination: This combination, often known by the brand Vytorin, pairs simvastatin with a cholesterol absorption inhibitor for added LDL and triglyceride reduction.

9. Rosuvastatin and Ezetimibe Combination: This combination, often known by the brand Roszet, offers strong LDL and triglyceride reduction for patients who need a more aggressive therapy.

10. Atorvastatin Extended Use in Combination Therapy: At times, atorvastatin is paired with other medications that target different cholesterol pathways for enhanced effect.

Patients comparing these common statins often also want a simple side-by-side breakdown. The table below summarizes the key differences.

Statin Comparison

Patients often also compare prices among these statins. Since generics are usually more affordable, price comparison platforms such as SaveHealth.com can help individuals check pharmacy listings and choose an economical option.

Common Side Effects of Statins

While statins are safe for most people, they can cause side effects. Many are mild and improve over time.

Common side effects

• Muscle soreness or stiffness

• Headache

• Digestive issues

• Fatigue

• Mild nausea

Less common but more serious side effects

• Muscle breakdown (Rhabdomyolysis)

• Liver enzyme elevation (jaundice)

• Increased blood sugar levels

If someone experiences side effects, switching to a different statin is a common solution. Cost can be a factor when switching, and many people use SaveHealth.com to compare prices for alternative statins before making a change.

Statin Effectiveness

Effectiveness varies based on the specific cholesterol goals and health profile.

High intensity statins

These are often prescribed for people who have had a heart attack or are at high cardiovascular risk.

• Atorvastatin

• Rosuvastatin

Moderate intensity statins

These are suitable for many adults with elevated cholesterol but without major heart disease risk.

• Simvastatin

• Pravastatin

• Lovastatin

Low intensity or gentle options

These are typically chosen for those with statin intolerance.

• Fluvastatin

• Pitavastatin (moderate intensity with lower risk of side effects)

Although high intensity options are strong, affordability can influence decisions. Tools like SaveHealth.com help patients identify which statin options fit their budget while still meeting medical needs.

Statin Uses and Benefits

Statins do more than lower cholesterol. Over time, they provide a range of protective benefits.

Benefits of statin therapy

• Reduce plaque buildup in arteries

• Lower risk of heart attack

• Lower risk of stroke

• Reduce inflammation in the cardiovascular system

• Improve overall long term heart health

People at high cardiovascular risk often see the greatest benefit. Because statins are typically taken long term, finding a cost effective option is important. This is why many individuals consult SaveHealth.com when renewing or adjusting their prescriptions.

Alternatives to Statins

For those who cannot tolerate statins or who need additional cholesterol lowering, several alternatives exist.

Common statin alternatives

• Ezetimibe

• PCSK9 inhibitors

• Bile acid sequestrants

• Lifestyle changes including diet and exercise

• Omega 3 prescription therapy

Even when exploring alternatives, many patients continue to compare pricing online, especially if adding a second medication to their regimen. SaveHealth.com can help reduce the combined cost of long term therapy.

How to Choose A Statin

Choosing a statin depends on health history, cholesterol levels, risk factors, budget, and tolerance.

Factors to consider

• How much LDL reduction is needed

• Personal or family history of heart disease

• Side effect sensitivity

• Drug interaction risks

• Insurance coverage

• Monthly cost

Since many statins have generic versions, most patients start with a cost effective option. By using SaveHealth.com, people can view pharmacy price differences before picking up their prescription, which helps them remain consistent with treatment.

Statin Medications & Prescriptions

Statins remain one of the most effective tools for managing high cholesterol and reducing cardiovascular risk. With several widely used options available, understanding the strengths and differences of each medication can help patients make informed decisions. Since cost can influence which statin is chosen and how consistently it is taken, using price comparison tools such as SaveHealth.com can make treatment more affordable and improve long term adherence.

References

• Cleveland Clinic. Statins for Cholesterol Management. https://my.clevelandclinic.org/health/treatments/22282-statins

• Mayo Clinic. Cholesterol Lowering Medications. https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/cholesterol-medications/art-20050958

• Drugs.com. HMG CoA Reductase Inhibitors. https://www.drugs.com/drug-class/hmg-coa-reductase-inhibitors.html

• Heart and Stroke Foundation. Statin Information. https://www.heartandstroke.ca/heart-disease/treatments/medications/statins

• Johns Hopkins Lupus Center. Statins and Cholesterol Medications. https://www.hopkinslupus.org/lupus-treatment/common-medications-conditions/cholesterol-medications-statins