Aleve vs Advil - What's The Difference? Comparing These NSAIDs

By: Noah W Chung | PharmD

SaveHealth the prescription discount website, compares Aleve vs Advil. Aleve (naproxen sodium) and Advil (ibuprofen) are two of the most widely used over-the-counter NSAIDs for pain relief and inflammation. While both medications share similarities in their ability to reduce fever and alleviate discomfort from headaches, muscle aches, and arthritis, key differences in their duration, dosing, and safety profiles make each unique. This comprehensive guide compares these pain relievers to help you make informed decisions about which medication best suits your needs. 

Aleve vs Advil - Key Similarities 

Both Aleve and Advil: 

• Belong to the NSAID class (non-steroidal anti-inflammatory drugs) 

• Inhibit COX-1 and COX-2 enzymes to reduce pain/inflammation 

• Treat common conditions: 

  • Headaches 

  • Menstrual cramps 

  • Arthritis pain 

  • Muscle strains 

  • Fever 

• Carry FDA warnings about cardiovascular and gastrointestinal risks 

• Available in multiple forms (tablets, gelcaps, liquid suspensions) 

Aleve vs Advil - Critical Differences 

Advil vs Aleve - Side Effect Comparison

Common to Both: 

• Heartburn

• Stomach irritation

• Dizziness

• Fluid retention

• Nausea

Unique Risks: Aleve vs Advil

Studies suggest Advil may cause fewer stomach ulcers, while Aleve may pose lower cardiovascular risks at recommended doses. 

Aleve vs Advil - Dosage Guidelines 

Aleve: 

• Adults: 1 tablet every 8-12 hours

• First dose: 2 tablets if needed

• Not to exceed 3 tablets/24 hrs unless authorized by healthcare physician

Advil: 

• Adults: 1-2 tablets every 4-6 hours 

• Max 6 tablets/24hrs 

• Pediatric dosing by weight: 

  • 3-23 months: 50mg/1.25ml

  • 2-11 years: 100mg/5ml, chewable available

  • •Weight base 5-10mg/kg per dose

Always take with food/water to reduce stomach irritation. 

Advil vs Aleve - Safety Considerations 

Cardiovascular: 

• FDA warns all NSAIDs increase heart attack/stroke risk 

• Aleve may have slightly lower cardiovascular risk based on long-term studies

Gastrointestinal: 

• 30% higher GI bleeding risk with Aleve (Cleveland Clinic) 

• Proton pump inhibitors (PPIs) may be recommended for long-term users

Special Populations:

• Avoid both in 3rd trimester pregnancy 

• Use caution with: 

  • Kidney disease 

  • High blood pressure 

  • History of ulcers 

  • Blood thinners 

Aleve vs Advil - When to Choose Each Medication 

Aleve Works Best For: 

• Chronic conditions (e.g., osteoarthritis) 

• Prolonged pain relief needs 

• Patients at higher cardiovascular risk 

Advil Preferred For: 

• Acute injuries (sprains, strains) 

• Fever reduction in children 

• Short-term use (<10 days) 

• Patients with stomach sensitivity 

Clinical trials show both are equally effective for most pain types when used appropriately.

Important Warnings 

1. Never combine Aleve + Advil - Increases toxicity risks 

2. Watch for cross-medication ingredients (cold/flu products) 

3. Discontinue use if experiencing: 

• Chest pain 

• Vision changes 

• Black stools 

• Slurred speech 

4. 60% of NSAID-related hospitalizations involve improper dosing (NIH data)

Prescription Discounts on NSAIDs

This article is for educational purposes only and does not substitute for professional medical advice. Always consult your healthcare provider before starting or changing medication.