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The following safety information is crucial for those considering or currently using Depo-Estradiol (estradiol cypionate). Carefully review these warnings and consult your healthcare provider for any questions or concerns.

• Uterine or Endometrial Cancer: Depo-Estradiol may increase the risk of uterine or endometrial cancer due to its estrogen-like effects, which can alter the uterine lining. Patients with a healthy uterus should also take a progestin to mitigate this risk. Report any unusual vaginal bleeding to your healthcare provider immediately for further evaluation. Risk factors include using Depo-Estradiol for over a year, high doses of estrogen, and not combining estrogen with progestin.

• Breast Cancer: Estrogen medications, such as Depo-Estradiol, are associated with an increased risk of breast cancer. To minimize this risk, the smallest effective dose should be used for the shortest duration. Regular self-examinations and mammograms are recommended. Notify your healthcare professional if you notice any changes in breast appearance. Risks are higher with a personal or family history of breast cancer or prolonged use of estrogen and progestin.

• Blood Clots, Heart Attacks, and Strokes: This medication can elevate the risk of serious cardiovascular events like blood clots, heart attacks, and strokes. Individuals with a history of such conditions or who smoke should be particularly cautious. Seek immediate medical attention for symptoms such as limb pain, chest pain, severe headaches, breathing difficulties, or sudden changes in speech or vision. Risk factors include high blood pressure, diabetes, high cholesterol, smoking, obesity, and systemic lupus erythematosus (SLE).

• Risk of Dementia: Starting Depo-Estradiol after age 65 may increase dementia risk. This medication should not be used expressly to prevent dementia. Consult your healthcare provider if you have concerns about cognitive health. Risk is particularly noted in females aged 65 and older.

• Gallbladder Issues: Depo-Estradiol may lead to gallbladder problems, sometimes necessitating removal. Report persistent stomach pain, nausea, vomiting, fever, or jaundice to your healthcare provider.

• Calcium Level Changes: Estrogen therapy might alter blood calcium levels, especially in patients with breast cancer metastasized to bones. Symptoms of high calcium include fatigue, muscle weakness, nausea, vomiting, or constipation. Risk factors include breast cancer, bone metastasis, and low parathyroid hormone levels.

• Vision Problems: Rare cases of vision issues due to clot formation in the eyes have been reported. Discontinue use and contact your prescriber if you experience vision loss, bulging eyes, double vision, or migraines.

• Low Thyroid Hormone Levels: Depo-Estradiol can affect thyroid hormone levels. Those on thyroid replacement therapy may need dosage adjustments. Regular blood tests to monitor thyroid levels may be necessary.

• Fluid Retention: This medication may cause fluid retention, potentially worsening heart or kidney conditions. Report unusual swelling or rapid weight gain to your healthcare provider.

• Increased Side Effects in Liver Dysfunction: Individuals with liver issues may experience heightened side effects due to how this medication is processed. Those with a history of liver problems should avoid using Depo-Estradiol.

• High Triglycerides: Estrogens can increase triglyceride levels, leading to heart issues or pancreatitis. Regular blood tests may be ordered to monitor triglyceride levels. Seek medical help for sudden abdominal pain, nausea, or rapid heart rate.

• Worsening of Other Conditions: Estrogen can exacerbate conditions like high blood pressure, hereditary angioedema, asthma, diabetes, migraines, and seizures. Discuss your medical history with your healthcare provider before starting treatment.

Contraindications: Avoid using Depo-Estradiol if you have:

• Unexplained abnormal vaginal bleeding
• Current or past breast cancer
• Estrogen-dependent cancers
• High risk for blood clots
• History of blood clots, stroke, or heart attack
• Bleeding disorders
• Liver issues
• Pregnancy

Please ensure you consult your healthcare provider for personalized advice and further information regarding Depo-Estradiol therapy.

Common side effects:

• Injection-site pain
• Breast tenderness or growth
• Nausea or vomiting
• Headaches
• Stomach cramps
• Vaginal spotting or irregular bleeding

Less common but important to monitor:

• Dizziness
• High blood pressure
• Melasma (dark patches on the skin)
• Difficulty tolerating contact lenses
• Mood changes
• Fluid retention leading to swelling
• Hair loss

Serious side effects:

• Signs of a heart attack (chest pain or tightness, pain spreading to shoulder, arm, neck, or jaw)
• Stroke symptoms (sudden trouble speaking or walking, numbness on one side of the body, severe headache)
• Deep vein thrombosis (leg cramps, swelling, pain, or muscle tightness)
• Pulmonary embolism (coughing, chest pain, breathing difficulties, or a racing heart)
• Liver or gallbladder issues (yellowing of the skin or eyes, fatigue, right upper stomach pain, dark urine)
• Unusual vaginal bleeding, discharge, or pelvic pain