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It is important to be aware of the potential risks and precautions when using ibuprofen-based medications, such as Duexis. Below are key safety considerations and warnings for patients and healthcare professionals to review:

• Heart Risks: Ibuprofen may increase the risk of heart attack or stroke, particularly with long-term use or in individuals with existing heart conditions or risk factors like smoking or high blood pressure. Do not use this medication immediately before or after heart bypass surgery. Seek immediate medical help if you experience chest pain, shortness of breath, or weakness on one side of the body.

• Stomach and Intestinal Bleeding: Serious bleeding from the stomach or intestines can occur without warning. This risk is heightened in older adults and those with a history of ulcers or bleeding. Look out for symptoms such as persistent stomach pain, black stools, or vomit that resembles coffee grounds, and seek medical assistance if they occur.

• Blood Pressure and Heart Failure: Ibuprofen may lead to fluid retention, elevated blood pressure, or worsening heart failure. Individuals with heart disease or those taking blood pressure medications should consult their healthcare provider before use and report any signs of chest pain or irregular heartbeat.

• Kidney and Liver Issues: The medication can harm kidneys, particularly in older adults or those with pre-existing conditions like diabetes. Watch for changes in urination or symptoms of kidney failure. Although rare, liver damage can occur; symptoms include jaundice or dark urine. Contact your healthcare provider if these arise.

• Severe Allergic Reactions: Life-threatening allergic reactions such as anaphylaxis may happen, especially in those with allergies to NSAIDs or aspirin. Immediate medical attention is required if symptoms like swelling or difficulty breathing occur.

• Pregnancy Warning: Ibuprofen is not recommended during the second half of pregnancy due to potential harm to the unborn child. Discuss alternative treatments with your healthcare provider if pregnant.

• Overdose Risks: Accidental overdose can occur if combined with other NSAID-containing products, leading to severe side effects like kidney failure or heart attack.

• Vision Changes: Blurred or altered vision may result from this medication. Avoid driving or operating machinery until you understand how it affects you, and consult your healthcare provider if vision issues develop.

• Contraindications: Do not use if you have allergies to ibuprofen, famotidine, or other related medications, or if you have a history of adverse reactions to NSAIDs. It is also contraindicated right before or after heart surgery like CABG.

Always discuss the benefits and risks of this medication with your healthcare provider to ensure it is safe for your use.

Common side effects:

• Nausea
• Upset stomach
• Diarrhea
• Constipation
• Headaches
• Vomiting
• Flu-like symptoms
• Sinus infections
• Cough
• Back pain

• Increased blood pressure

  Serious side effects:

• Stroke symptoms (lightheadedness, blurred vision, weakness on one side of the body)
• Heart attack symptoms (chest pain, trouble breathing)
• Heart failure (sudden weight gain, tiredness)
• Kidney damage (changes in urination, swelling)
• Liver damage (yellowing of the skin or eyes, dark urine)
• Severe asthma attacks
• Serious allergic reactions
• Skin reactions (painful blisters, peeling skin)
• Aseptic meningitis (severe headaches, neck stiffness)

Certain medications can interact with this drug and may need to be avoided or used with caution. These include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers like Valsartan and Losartan, Cidofovir, fezolinetant, Lithium, corticosteroids such as Prednisone, and diuretics like Furosemide. Additionally, taking this medication with anti-platelet drugs like Clopidogrel or blood thinners such as Dabigatran, Enoxaparin, and Warfarin may increase the risk of bleeding.

Be sure to read all labels on prescription and over-the-counter medications, as many contain pain relievers or fever reducers like Aspirin or NSAIDs such as Celecoxib, Ketorolac, or Naproxen. These are similar to ibuprofen and could increase the likelihood of side effects if used together. However, if your doctor has advised you to take low-dose aspirin (81-162 milligrams daily) to prevent heart attack or stroke, continue doing so unless otherwise directed. Daily ibuprofen use can reduce aspirin's effectiveness in preventing heart issues. Discuss with your doctor about possibly using Acetaminophen for pain relief instead. If ibuprofen is necessary, consult your doctor about coordinating its use with immediate-release aspirin. Take ibuprofen either 8 hours before or 2 hours after your aspirin dose. Do not alter your aspirin dosage or how you take any medication without your doctor's consent.

Some medications need stomach acid for proper absorption. Since famotidine reduces stomach acid, it can affect the absorption of certain drugs, including Atazanavir, dasatinib, specific azole antifungals like Itraconazole and Ketoconazole, levoketoconazole, Pazopanib, and sparsentan.