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The following safety information is crucial for understanding the potential risks and necessary precautions when using this medication. Review these details carefully, and consult your healthcare provider with any questions or concerns.

• Medication Interactions: Notify your healthcare provider or pharmacist about all current medications and supplements prior to beginning norethindrone to ensure compatibility and avoid interactions.

• Ectopic Pregnancy or Ovarian Cyst: If you become pregnant while taking norethindrone, there is a slight risk of an ectopic pregnancy, which occurs outside the uterus and can be serious. Seek immediate medical attention if you experience symptoms such as cramping or pain in the lower abdomen or shoulder area.

• Irregular Vaginal Bleeding: While irregular bleeding is a common side effect of progestin-only pills (POPs) like norethindrone, it can occasionally indicate more serious conditions, such as infections or cancer. Consult your healthcare provider if irregular bleeding occurs, or if there is an absence of bleeding, to assess the possibility of pregnancy.

• Possible Cancer Risk: Some research indicates that combination birth control pills may increase the risk of breast or ovarian cancer. However, it is unclear if norethindrone or other POPs have the same effect. Discuss any concerns regarding cancer risks with your healthcare provider.

The following conditions or factors indicate when norethindrone should not be used due to significant health risks. If any apply to you, consult your healthcare provider before use:

• Pregnancy
• Confirmed or suspected breast cancer
• Unexplained bleeding between menstrual periods
• Liver tumor, whether benign or malignant
• Acute liver disease

By understanding these warnings and contraindications, you can ensure safer use of the medication. Always follow the guidance of your healthcare provider.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, headaches, bloating, breast tenderness, or weight gain. Additionally, irregular periods or spotting between menstrual cycles can occur. These effects are usually mild, but if they persist or worsen, it is advisable to consult your healthcare provider.

In rare cases, more serious side effects might occur. These include lumps in the breast, significant mood changes such as new or worsening depression, severe stomach or abdominal pain, or unusual changes in vaginal bleeding patterns, such as continuous spotting or sudden heavy bleeding. Other severe symptoms that necessitate immediate medical attention include dark urine, yellowing of the eyes or skin, and symptoms indicative of an ectopic pregnancy, such as severe stomach pain and spotting.

Although a very serious allergic reaction to this medication is rare, you should seek urgent medical help if you notice a rash, severe dizziness, trouble breathing, or swelling, especially of the face, tongue, or throat. This is not an exhaustive list of side effects. Always consult a healthcare professional if you notice other effects not mentioned here.