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Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), carries specific risks and precautions that users should be aware of. Here is a summary of the primary safety information:

• Increased Risk of Heart Issues: Ketoprofen might increase the risk of heart attack or stroke, which can occur at any time during use, especially with long-term consumption. This risk is heightened in older adults and individuals with heart disease or risk factors such as smoking, family history, high blood pressure, or diabetes. It is crucial not to take this medication immediately before or after heart bypass surgery (CABG).

• Gastrointestinal Risks: There is a rare but serious risk of bleeding in the stomach or intestines, potentially fatal, which can arise without warning at any time during treatment. Older adults are particularly vulnerable to this side effect.

• Serious Side Effects: Discontinue use and seek immediate medical attention if you experience any of the following symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden vision changes.

• Consultation with Healthcare Provider: It is important to discuss the potential benefits and risks associated with ketoprofen with a healthcare professional, such as a doctor or pharmacist, before starting treatment.

This information is critical for ensuring safe and informed use of ketoprofen.

When taking this medication, it's common to experience mild side effects like an upset stomach, nausea, constipation, diarrhea, gas, dizziness, drowsiness, blurred vision, or headaches. These effects usually don't last long, but if they persist or worsen, consult a healthcare professional. Most people taking this medication do not experience serious issues.

It's important to monitor your blood pressure regularly, as this medication can cause it to rise. Inform your healthcare provider if you observe any increases. Rare but serious side effects to be aware of include changes in hearing, mood alterations, unusual bleeding or bruising, difficulty swallowing, and symptoms indicative of kidney issues, such as changes in urine output or blood in urine. Watch for signs of heart failure, like swollen ankles or feet, extreme fatigue, or unexpected weight gain.

Ketoprofen can rarely lead to severe liver damage. Seek immediate medical attention if you notice persistent nausea or vomiting, loss of appetite, stomach pain, jaundice, or dark urine. Although a severe allergic reaction is uncommon, be vigilant for symptoms like fever, swollen lymph nodes, rashes, or difficulty breathing, and seek urgent care if they occur.

This overview does not cover all possible side effects. If you experience any symptoms not mentioned here, reach out to a healthcare provider for guidance. Always report significant side effects to your local health authority.

Certain medications can interact with this drug, potentially leading to adverse effects. These include Aliskiren, ACE inhibitors (like Benazepril and Lisinopril), angiotensin II receptor blockers (such as Losartan and Valsartan), Cidofovir, corticosteroids (like Dexamethasone and Prednisone), Lithium, Methotrexate, and diuretics (such as Furosemide). Additionally, this drug may increase bleeding risk if taken with other medications that also promote bleeding, such as anti-platelet drugs like Clopidogrel and anticoagulants like Dabigatran, Enoxaparin, or Warfarin.

It's important to examine both prescription and over-the-counter medication labels, as many contain pain relievers or fever reducers, such as Aspirin and NSAIDs (like Ibuprofen, Ketorolac, or Naproxen). These are similar to Ketoprofen and may heighten the likelihood of side effects if used in conjunction. However, if your healthcare provider has prescribed low-dose aspirin for heart attack or stroke prevention (typically 81-162 milligrams daily), continue with it unless advised otherwise by your doctor. For further guidance, consult your doctor or pharmacist.